TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

7703-

,

Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation

-

in-vitro,

AML,

PLB-985

TumCG↓, TumCD↑, Diff↑, NOX2↑, ROS↑,

7625-

,

Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair

-

in-vitro,

sarcoma,

NA

TumCD↑, TumCCA↑, Apoptosis↑, BRCA2↓, ChemoSen↑,

6467-

1,8-Cin,

Evaluation of in vitro anticancer activity of 1,8-Cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential

-

in-vitro,

Melanoma,

A431

-

in-vitro,

OS,

MG63

-

in-vitro,

Nor,

HaCaT

TumCP↓, selectivity↑, AntiCan↑, TumCD↑, Apoptosis↑, Dose↝, ROS↑,

2325-

2DG,

Research Progress of Warburg Effect in Hepatocellular Carcinoma

-

Review,

Var,

NA

HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,

5278-

3BP,

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

Caco-2

-

in-vitro,

CRC,

SW48

ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,

5259-

3BP,

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP

-

in-vivo,

HCC,

NA

highly glycolytic cancers.  young rats. Advanced cancers (2-3cm) developed

ATP↓, TumCD↑, toxicity↓, eff↑, tumCV↓, Dose↝,

5471-

AF,

Anti-Tumoral Treatment with Thioredoxin Reductase 1 Inhibitor Auranofin Fosters Regulatory T Cell and B16F10 Expansion in Mice

-

vitro+vivo,

Melanoma,

B16-F10

TrxR1↓, AntiTum↑, ROS↑, NRF2↑, TumCD↑,

4402-

AgNPs,

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

-

in-vitro,

BC,

BT549

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

Nor,

MCF10

TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,

4406-

AgNPs,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

-

in-vitro,

BC,

MCF7

63.1 ± 8.3 nm

tissues from 64 patients

-

in-vitro,

BC,

T47D

-

in-vitro,

BC,

MDA-MB-231

TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,

4361-

AgNPs,

GoldNP,

Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives

-

in-vivo,

Liver,

HepG2

IC50 values of the AgNPs, AuNPs and Ag/AuNPs on HepG2 cells were determined as 38.42 μg ml-1, 43.25 μg ml-1 and 39.20 μg ml-1

Sprague Dawley (SD) rat model

TumCD↑, TumVol↓, *toxicity↝, hepatoP↑,

4358-

AgNPs,

HPT,

Rad,

Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells

-

in-vitro,

GBM,

U251

10 nm silver nanoparticles (AgNPs) on human glioma U251 c

RadioS↑, eff↑, TumCD↑,

4430-

AgNPs,

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

-

in-vitro,

Colon,

HCT116

20 nm

-

in-vitro,

Nor,

NCM460

*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,

4439-

AgNPs,

Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)

-

in-vitro,

Cerv,

HeLa

33 nm

ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

-

in-vitro,

BC,

MCF7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4379-

AgNPs,

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

-

in-vitro,

CRC,

LoVo

eff↑, TumCD↑, ROS↑, Bacteria↓,

4374-

AgNPs,

Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides

-

in-vitro,

BC,

MCF7

eff↑, TumCD↑,

4373-

AgNPs,

In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells

-

in-vitro,

Liver,

HepG2

TumCD↑,

4372-

AgNPs,

Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

Lung,

A549

TumCD↑,

4661-

AgNPs,

Silver nanoparticles induces apoptosis of cancer stem cells in head and neck cancer

-

in-vitro,

HNSCC,

NA

TumCD↑, CSCs↝,

341-

AgNPs,

Bioprospecting a native silver-resistant Bacillus safensis strain for green synthesis and subsequent antibacterial and anticancer activities of silver nanoparticles

-

in-vitro,

Liver,

HepG2

TumCD↑, ROS↑,

340-

AgNPs,

Screening bioactivities of Caesalpinia pulcherrima L. swartz and cytotoxicity of extract synthesized silver nanoparticles on HCT116 cell line

-

in-vitro,

CRC,

HCT116

 18ug

TumCD↑,

339-

AgNPs,

Cancer cell specific cytotoxic potential of the silver nanoparticles synthesized using the endophytic fungus, Penicillium citrinum CGJ-C2

-

in-vitro,

BC,

MCF7

-

in-vitro,

Melanoma,

A431

-

in-vitro,

HCC,

HepG2

TumCD↑,

338-

AgNPs,

Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer

-

vitro+vivo,

Bladder,

5637

 mice

TumCD↑, Apoptosis↑, TumCMig↓, TumCP↓,

365-

AgNPs,

Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species

-

in-vitro,

Hepat,

HepG2

 0.5–7.5 µg/mL 5 nm

ROS↑, GlucoseCon↓, TumCD↑, NRF2↓,

364-

AgNPs,

Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

-

in-vitro,

Lung,

A549

 202ug/cm3

 most resistant

-

in-vitro,

Hepat,

HepG2

 15.8ug/cm3

 Decreased mRNA expression of most ABC transporters (not ABCB1)

-

in-vitro,

CRC,

SW-620

 39.4ug/cm3

 Increased mRNA expression of most ABC transporters (not ABCB1)

TumCD↑,

352-

AgNPs,

Synthesis of silver nanoparticles (Ag NPs) for anticancer activities (MCF 7 breast and A549 lung cell lines) of the crude extract of Syzygium aromaticum

-

in-vitro,

BC,

MCF7

TumCD↑,

354-

AgNPs,

Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function

-

in-vitro,

neuroblastoma,

SH-SY5Y

  Ca2+ overload and disrupted homeostasis in the mitochondria triggered apoptotic cell death.

TumCD↑, ER Stress↑, GRP78/BiP↑, p‑PERK↑, CHOP/DDIT3↑, Ca+2↑, XBP-1↑, p‑IRE1↑,

6404-

ANE,

Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae

-

in-vitro,

Var,

NA

ROS↑, DNAdam↑, TumCD↑,

4759-

antiOx,

Chemo,

Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization

-

Review,

Var,

NA

TumCD↑, TumCG↓, ROS⇅, eff↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,

2635-

Api,

CUR,

Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells

-

in-vitro,

Cerv,

HeLa

TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,

2638-

Api,

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

-

in-vitro,

lymphoma,

PEL

TumCD↑, TumAuto↑, ROS↓, P53↑, Catalase↑, STAT3↓,

3160-

Ash,

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

-

Review,

Var,

NA

TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,

2003-

Ash,

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

-

in-vitro,

Pca,

PC3

2 μM WA

-

in-vitro,

Pca,

DU145

-

in-vitro,

Nor,

TIG-1

-

in-vitro,

PC,

LNCaP

TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,

4819-

ASTX,

Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway

-

in-vitro,

BC,

MCF7

5, 10, 25, 50, 75, 100, 125, and 150 μg/mL)

IC50 = 89.742 μg/mL

antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,

4818-

ASTX,

MEL,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

T47D

-

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,

4807-

ASTX,

An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms

-

Review,

Var,

NA

*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,

5362-

AV,

Anti-cancer effects of aloe-emodin: a systematic review

-

Review,

Var,

NA

AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,

1523-

Ba,

Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression

-

in-vitro,

OS,

MG63

(12.5, 25, and 50 μM)

-

in-vitro,

Nor,

hFOB1.19

TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,

2023-

BBR,

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

-

in-vitro,

Colon,

NA

0-100uM

-

in-vitro,

Nor,

YAMC

TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,

2680-

BBR,

PDT,

Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death

-

in-vitro,

Liver,

HUH7

TumCD↑, ROS↑, TumCCA↑, ER Stress↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

-

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

-

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

-

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2716-

BetA,

Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment

-

Review,

Var,

NA

AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1 / PDPK1↓,

5715-

BF,

Bufalin for an innovative therapeutic approach against cancer

-

Review,

Var,

NA

selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,

5476-

BM,

In Vitro Synergistic Inhibition of HT-29 Proliferation and 2H-11 and HUVEC Tubulogenesis by Bacopaside I and II Is Associated with Ca2+ Flux and Loss of Plasma Membrane Integrity

-

vitro+vivo,

CRC,

HT29

TumCD↑, TumCMig↓, Ca+2↑,

745-

Bor,

Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

Nor,

L929

-

in-vitro,

GBM,

T98G

TumCD↑, *toxicity↓,

6543-

BSB,

alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells

-

in-vitro,

GBM,

U87MG

tumCV↓, selectivity↑, TumCD↑, Apoptosis↑, MOMP↓, Cyt‑c↑, cl‑PARP↑,

6545-

BSB,

The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes

MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,

7975-

BUL,

Bullatacin--in vivo and in vitro experience in an ovarian cancer model

-

in-vitro,

Ovarian,

OVCAR-3

mice

toxicity↝, TumCD↑,

1640-

CA,

MET,

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

-

in-vitro,

Cerv,

SiHa

GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,

5746-

CA,

Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

LNCaP

tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,

Showing Research Papers: 1 to 50 of 196
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 196

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

APOE4↑, 1, NA↑, 2, NOX2↑, 1, TFE3↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, ATF3↑, 1, Catalase↓, 3, Catalase↑, 2, compI↓, 2, Fenton↑, 2, Ferroptosis↑, 4, GPx↓, 1, GPx↑, 1, GPx4↓, 2, GPx4↑, 1, GSH↓, 12, GSH↑, 1, GSH⇅, 1, GSH/GSSG↓, 2, GSR↓, 1, GSR↑, 1, GSTP1/GSTπ↓, 1, H2O2↑, 9, i-H2O2↑, 1, mt-H2O2↑, 1, HO-1↓, 3, HO-1↑, 1, ICD↑, 1, Iron↑, 4, Keap1↓, 1, lipid-P↑, 8, MDA↑, 3, NQO1↑, 1, NRF2↓, 4, NRF2↑, 2, OXPHOS↓, 1, OXPHOS↑, 1, PARK2↑, 1, ROS↓, 6, ROS↑, 89, ROS⇅, 3, ROS∅, 1, i-ROS↑, 1, mt-ROS↑, 7, SIRT3↑, 1, SOD↓, 1, SOD↑, 1, SOD1↓, 1, SOD2↑, 1, Thiols↓, 1, Trx↓, 3, TrxR↓, 1, TrxR1?, 1, TrxR1↓, 2, xCT/SLC7A11↓, 3,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3, ATP↓, 9, ATP↑, 1, CDC2↓, 1, CDC25↓, 2, ETC↓, 4, ETC↝, 1, Insulin↓, 1, mitResp↓, 4, MMP?, 1, MMP↓, 43, MMP↝, 1, MPT↑, 2, mtDam↓, 1, mtDam↑, 12, OCR↓, 3, PINK1↑, 1, SDH↓, 1, XIAP↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1, ACC↑, 1, ACLY↓, 1, AKT1↓, 1, ALAT↓, 1, AMPK↑, 4, p‑AMPK↑, 1, cMyc↓, 3, CYP3A4↓, 1, FASN↓, 2, GLS↓, 1, GlucoseCon↓, 4, Glycolysis↓, 5, HK2?, 1, HK2↓, 3, lactateProd↓, 2, LDH?, 1, LDH↓, 3, LDH↑, 2, LDHA↓, 3, MCT4↓, 1, NAD↓, 2, NADPH↓, 2, NADPH↑, 1, PDH↓, 2, PDK1 / PDPK1↓, 2, PFK↓, 1, PKM2↓, 2, p‑PKM2↓, 1, PPARγ↑, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 2, Warburg↓, 2,

Cell Death(tgid=5) ⓘ

Akt↓, 21, Akt↑, 1, p‑Akt↓, 5, p‑Akt↑, 2, APAF1↑, 1, Apoptosis↓, 5, Apoptosis↑, 65, mt-Apoptosis↑, 1, autoS↑, 1, BAD↑, 2, BAX?, 1, BAX↓, 1, BAX↑, 20, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↓, 27, Bcl-xL↓, 5, BID↑, 2, BIM↑, 1, Casp↑, 8, Casp1↑, 1, Casp12↑, 1, Casp3↑, 33, cl‑Casp3↑, 10, proCasp3↓, 1, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 4, cl‑Casp7↑, 1, Casp8↑, 7, Casp9↑, 16, cl‑Casp9↑, 6, pro‑Casp9↑, 1, cFLIP↓, 2, Chk2↓, 1, CK2↓, 1, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 23, DR4↑, 1, Endon↑, 1, Fas↑, 3, FasL↑, 1, Ferroptosis↑, 4, HEY1↓, 1, Hippo↓, 1, hTERT/TERT↓, 1, IAP1↓, 1, JNK↓, 3, JNK↑, 5, p‑JNK↑, 2, MAPK↓, 3, MAPK↑, 2, p‑MAPK↓, 1, Mcl-1↓, 5, MOMP↓, 1, MOMP↑, 4, Necroptosis↑, 1, necrosis↑, 3, p27/CDKN1B↓, 1, p27/CDKN1B↑, 3, p38↓, 1, p38↑, 7, p‑p38↑, 2, Paraptosis↑, 2, Proteasome?, 1, survivin↓, 1, TRPV1↑, 1, TumCD↑, 196, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1, p‑p70S6↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1, ChrMod↑, 2, H3↑, 1, other?, 1, other↓, 2, other↑, 3, other↝, 8, PhotoS↑, 1, tumCV↓, 16, tumCV↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1, CHOP/DDIT3↑, 5, p‑eIF2α↑, 1, ER Stress↑, 14, GRP78/BiP↓, 1, GRP78/BiP↑, 3, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↑, 2, HSP90↓, 5, p‑IRE1↑, 1, p‑PERK↑, 1, UPR↑, 1, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2, ATG5↑, 3, Beclin-1/ATG6↑, 3, BNIP3?, 1, LAMP2↑, 1, LC3B-II↑, 2, LC3II↑, 1, MitoP↑, 2, p62↑, 1, p‑p62↑, 1, TumAuto↓, 1, TumAuto↑, 15,

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 2, CHK1↓, 1, DNAdam↑, 26, p16↑, 2, P53↓, 1, P53↑, 20, PARP↓, 3, PARP↑, 4, cl‑PARP↑, 16, PCNA↓, 3, γH2AX↑, 5,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK2↓, 6, CDK4↓, 6, CDKN2C/p18↑, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 8, cycD1/CCND1↓, 7, cycE/CCNE↓, 2, E2Fs↓, 2, mitA↓, 1, mitA↑, 1, P21↓, 1, P21↑, 9, p‑RB1↓, 1, TumCCA↓, 2, TumCCA↑, 57,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4, CD133↓, 1, CD44↓, 3, cFos↑, 1, CSCs↓, 11, CSCs↑, 1, CSCs↝, 1, CTSB↓, 1, CTSD↓, 1, Diff↓, 1, Diff↑, 1, EMT↓, 4, EpCAM↓, 2, ERK↓, 7, ERK↑, 1, p‑ERK↑, 2, FOXM1↓, 1, FOXO3↑, 1, FOXO4↑, 1, GSK‐3β↑, 1, HDAC↓, 2, IGF-1↓, 2, IGF-2↑, 1, mTOR↓, 7, mTOR↑, 1, p‑mTOR↓, 3, mTORC1↓, 1, mTORC2↓, 1, NOTCH↓, 1, NOTCH1↓, 2, OCT4↓, 2, P70S6K↓, 1, PI3K↓, 11, PI3K↑, 2, PTEN↑, 1, SOX2↓, 1, STAT↓, 1, STAT3↓, 8, STAT3↑, 1, p‑STAT3↓, 2, STAT5↓, 1, TCF↝, 1, TRPM7↑, 1, TumCG?, 1, TumCG↓, 26, Wnt↓, 2,

Migration(tgid=13) ⓘ

AP-1↓, 1, ATPase↓, 1, BACH1↓, 1, Ca+2↓, 1, Ca+2↑, 12, i-Ca+2↑, 1, i-Chl↑, 1, CLDN1↓, 1, DLC1↑, 1, E-cadherin↓, 1, E-cadherin↑, 3, ER-α36↓, 1, FAK↓, 1, hnRNPA1↓, 1, Ki-67↓, 2, LAMs↓, 1, MMP1↓, 1, MMP15↓, 1, MMP2↓, 9, MMP9↓, 7, MMPs↓, 4, N-cadherin↓, 4, PAK1↑, 1, PKCδ↓, 1, Slug?, 1, Slug↓, 4, Snail?, 1, Snail↓, 6, SOX4↓, 1, TIMP1↑, 1, TIMP2↓, 1, TIMP2↑, 1, Treg lymp↓, 1, TumCI↓, 9, TumCMig↓, 11, TumCP↓, 28, TumCP↑, 2, TumMeta↓, 15, Twist↓, 1, TXNIP↑, 1, uPA↓, 1, Vim↓, 2, Zeb1↓, 2, α-SMA↓, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 3, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14, angioG↑, 1, ATF4↑, 2, EGFR↓, 2, p‑EGFR↓, 1, EPR↑, 2, HIF-1↓, 1, Hif1a↓, 3, NO↑, 2, PDGFR-BB↓, 1, VEGF↓, 6,

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1, CellMemb↑, 4, GLUT1↓, 3, GLUT3↓, 1, GLUT4↓, 1, P-gp/ABCB1↓, 1, P-gp/ABCB1∅, 1, SVCT-2↝, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, cellSen↑, 1, COX2/PTGS2↓, 5, COX2/PTGS2↑, 1, DCells↑, 1, FOXP3↑, 1, HMGB1↓, 1, p‑IKKα↓, 1, IL6↓, 4, IL8↓, 2, Imm↑, 8, Inflam↓, 6, p‑IκB↓, 1, JAK↓, 1, JAK1↓, 1, JAK2↓, 1, M2 MC↓, 1, NF-kB↓, 15, NF-kB↑, 3, p‑NF-kB↓, 1, p65↓, 1, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1, Temp↓, 1, Temp∅, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1, CDK6↓, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 5, BioAv↝, 4, ChemoSen↑, 28, Dose?, 3, Dose↓, 2, Dose↑, 1, Dose↝, 25, Dose∅, 1, eff↓, 34, eff↑, 59, eff↝, 3, eff∅, 1, Half-Life↓, 1, Half-Life↑, 1, Half-Life↝, 1, RadioS↑, 10, selectivity↓, 1, selectivity↑, 48,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↑, 1, BG↓, 1, BloodF↑, 1, E6↓, 2, E7↓, 1, EGFR↓, 2, p‑EGFR↓, 1, Ferritin↓, 1, FOXM1↓, 1, GutMicro↑, 2, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↓, 4, Ki-67↓, 2, LDH?, 1, LDH↓, 3, LDH↑, 2, PD-L1↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12, AntiCan⇅, 1, antiNeop↑, 1, AntiP↑, 1, AntiTum↑, 8, Appetite↑, 1, breath↑, 1, cardioP↑, 1, chemoP↑, 7, chemoPv↑, 4, ChemoSideEff↓, 1, hepatoP↑, 2, MusCon↓, 2, NP/CIPN↓, 1, OS↑, 8, OS⇅, 1, Pain↓, 2, QoL↑, 2, radioP↑, 1, Remission↑, 1, RenoP↑, 1, Risk↓, 2, Sleep↑, 1, Strength↑, 2, toxicity↓, 7, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 2, Weight↑, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2, CD8+↑, 2,
Total Targets: 456

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1, Stroke↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 10, Catalase↑, 5, CYP2E1↓, 1, GPx↑, 3, GPx1↑, 1, GSH↑, 1, GSTs↑, 3, HO-1↓, 1, Keap1↝, 1, lipid-P↓, 2, MDA↓, 2, NRF2↑, 2, Prx↑, 1, RNS↓, 1, ROS↓, 12, ROS↑, 1, ROS∅, 2, mt-ROS?, 1, SOD↓, 1, SOD↑, 2, SOD1↑, 1, SOD2↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1, ATP↑, 1, ETC↝, 1, Insulin↑, 1, mitResp↑, 1, MMP↑, 2, MMP∅, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

BAX↓, 1, BMP2↑, 1, Casp1↓, 1, Casp3?, 1, Casp3↓, 2, Cyt‑c↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1, PI3K↓, 1, RUNX2↑, 1, STAT3↓, 1, TumCG∅, 1,

Migration(tgid=13) ⓘ

COL1↑, 1, VCAM-1↓, 1, β-Endo↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2, COX2/PTGS2↑, 1, IL18↓, 1, IL1β↓, 1, IL6↓, 3, Inflam↓, 7, pol-M2 MC↑, 1, NF-kB↓, 3, PGE2↓, 1, PSA∅, 1, TNF-α↓, 3,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 1, BDNF↑, 1, MAOA↓, 1, NGF↑, 1, p‑tau↓, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3, BioAv↑, 9, BioAv↝, 2, eff↑, 1, Half-Life∅, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BMD↑, 1, GutMicro↑, 1, IL6↓, 3, PSA∅, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4, antiAll↑, 1, AntiCan↑, 1, AntiDiabetic↑, 2, AntiP↑, 2, antiPs↑, 1, AntiTum↑, 2, chemoP↑, 1, cognitive↑, 2, hepatoP↑, 2, memory↑, 1, neuroP↑, 4, Obesity↓, 1, OS↑, 1, RenoP↑, 1, toxicity↓, 12, toxicity↑, 2, toxicity↝, 5,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2, Bacteria↓, 3,
Total Targets: 113

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

22 Silver-NanoParticles
11 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
9 Magnetic Field Rotating
6 Electrical Pulses
6 Selenite (Sodium)
5 Copper and Cu NanoParticles
5 Dandelion Root
5 Disulfiram
5 Ivermectin
4 Chemotherapy
4 Curcumin
4 Eugenol
4 Phenethyl isothiocyanate
4 Quercetin
3 Radiotherapy/Radiation
3 Astaxanthin
3 Melatonin
3 Chrysin
3 Date Fruit Extract
3 Eurycomanone
3 Fisetin
3 salinomycin
3 VitK3,menadione
2 3-bromopyruvate
2 Hyperthermia
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Boron
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 Metformin
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 Emodin
2 Fenbendazole
2 Ginkgetin
2 Gossypol/AT-101
2 Isobavachalcone
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 isoorientin
2 Kaempferol
2 lambertianic acid
2 Lemongrass Extract/Citral
2 Magnesium
2 Phenylbutyrate
2 Selenium
1 1,8-Cineole
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Anethole/trans-Anethole
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Photodynamic Therapy
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Bullatacin
1 Carnosic acid
1 Rosmarinic acid
1 Capsaicin
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 chitosan
1 Chlorophyllin
1 Docetaxel
1 Zinc
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Deguelin
1 Echinacea
1 Cannabichromene
1 eicosapentaenoic acid
1 Formononetin
1 Galloflavin
1 Grapeseed extract
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Honokiol
1 Indole-3-carbinol
1 iodine
1 Paclitaxel/Taxol
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Licochalcone A
1 Linalool
1 Luteolin
1 Methylene blue
1 SonoDynamic Therapy UltraSound
1 methotrexate
1 Nimbolide
1 Propyl gallate
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Selenium NanoParticles
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Vitexin
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:619  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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