GlucoseCon Cancer Research Results

GlucoseCon, Glucose Consumption: Click to Expand ⟱
Source:
Type:
Glucose consumption is often elevated in cancer cells due to an increased reliance on glycolysis for energy production, even in the presence of oxygen. This phenomenon, known as the Warburg effect, is a metabolic shift that allows cancer cells to rapidly proliferate and survive in nutrient-poor environments.

The increased glucose consumption in cancer cells can be detected using positron emission tomography (PET) scans, which measure the uptake of a glucose analog labeled with a radioactive tracer.
Scientific Papers found: Click to Expand⟱
6669- Deg,    Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
- vitro+vivo, Pca, NA
other↝, ETC↓, TumCG↓, OCR↓, GlucoseCon↑, MMP↓, other↝,
7298- GlaB,    Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, NA
Gli1↓, GlucoseCon↑, lactateProd↝, Warburg↑,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
2541- M-Blu,    Spectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism
- in-vivo, Var, NA
TumCG↓, Glycolysis↓, OXPHOS↑, ROS↑, OCR↑, GlucoseCon↑, lactateProd↓,
1226- OLST,    Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation
- vitro+vivo, GC, NA
PGM1∅, FASN↓, Apoptosis↑, lipidLev↑, GlucoseCon↑, eff↑,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

OXPHOS↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   MMP↓, 1,   OCR↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   GlucoseCon↑, 7,   Glycolysis↓, 2,   Glycolysis↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   lactateProd↑, 2,   lactateProd↝, 1,   LDHA↑, 1,   lipidLev↑, 1,   PDH↓, 1,   PFK1↓, 1,   PGM1∅, 1,   Pyruv↓, 1,   TCA↓, 1,   Warburg↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1,   mTORC1↓, 1,   PI3K↑, 2,   p‑STAT3↓, 1,   p‑STAT5↓, 1,   TumCG↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 5,   eff↑, 3,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: GlucoseCon, Glucose Consumption
2 Vitamin K2
1 Deguelin
1 Glabrescione B
1 Ivermectin
1 Methylene blue
1 Orlistat
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:623  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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