GranB/GZMB Cancer Research Results

GranB/GZMB, Granzyme B: Click to Expand ⟱
Source:
Type: serine protease
Granzyme B is a serine protease that is expressed by cytotoxic T cells and natural killer cells, and plays a crucial role in the immune system's ability to eliminate infected cells and tumor cells. Granzyme B works in conjunction with perforin to induce apoptosis (programmed cell death) in target cells.

In the context of cancer, granzyme B has been found to have both positive and negative effects.

Granzyme B is an important marker of immune activity in the tumor microenvironment, and its expression is often associated with better prognosis in various cancers. High levels of Granzyme B in tumor-infiltrating lymphocytes indicate an effective anti-tumor immune response, which can help control tumor growth and improve patient outcomes.


Scientific Papers found: Click to Expand⟱
8372- LT,    Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, PrxII↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↑, GranB/GZMB↑,
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB/GZMB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

PrxII↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↑, 1,   GranB/GZMB↑, 2,   Perforin↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK2↓, 1,   NK cell↑, 1,   PD-L1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GranB/GZMB, Granzyme B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:872  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page