AntiTum Cancer Research Results

AntiTum, AntiTumor: Click to Expand ⟱

Source:

Type:

AntiTumor

Scientific Papers found: Click to Expand⟱

6475-

1,8-Cin,

1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression

-

in-vitro,

HNSCC,

NA

*P-sel↓, Inflam↓, AntiTum↑, AntiAg↑,

6466-

1,8-Cin,

Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y

-

in-vitro,

neuroblastoma,

SH-SY5Y

AntiTum↑, TumCCA↑, PDGFRB↓, Myc↓, LEF1↓, BAD↑, APC↑, TBX3↑,

5269-

3BP,

The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.

-

in-vitro,

HCC,

NA

toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,

5314-

acetaz,

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

-

Review,

Var,

NA

AntiTum↑, CA↓,

5462-

AF,

Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy

-

Review,

Var,

NA

AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,

5471-

AF,

Anti-Tumoral Treatment with Thioredoxin Reductase 1 Inhibitor Auranofin Fosters Regulatory T Cell and B16F10 Expansion in Mice

-

vitro+vivo,

Melanoma,

B16-F10

TrxR1↓, AntiTum↑, ROS↑, NRF2↑, TumCD↑,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5444-

AG,

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

-

Review,

Var,

NA

*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

4394-

AgNPs,

Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways

-

in-vivo,

lymphoma,

NA

OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

-

in-vitro,

BC,

MCF7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4378-

AgNPs,

Exploring silver nanoparticles for cancer therapy and diagnosis

-

Review,

Var,

NA

AntiTum↑, ROS↑, eff↑, RadioS↑,

4383-

AgNPs,

Exploring the Potentials of Silver Nanoparticles in Overcoming Cisplatin Resistance in Lung Adenocarcinoma: Insights from Proteomic and Xenograft Mice Studies

-

in-vitro,

Lung,

A549

AgNPs was 23.45 nm, with zeta potentials lying on −20.33 mV.

-

in-vivo,

Lung,

A549

A549 and A549/DDP-bearing mice

Apoptosis↑, VEGF↓, P53↓, TumCCA↑, ROS↑, AntiTum↑, eff↑, ATP↓, eff↑, CTR1↑,

4546-

AgNPs,

Chapter 2 - Silver nanoparticles in cancer therapy

-

Study,

Var,

NA

AntiTum↑, Apoptosis↑,

5352-

AL,

Anticancer potential of allicin: A review

-

Review,

Var,

NA

*cardioP↑, *Bacteria↓, *Inflam↓, AntiTum↑, *DNAdam↓, TumCP↓, angioG↓, TumMeta↓,

6601-

Anamu,

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model

-

in-vitro,

AML,

NA

AntiTum↑, GlucoseCon↓, ROS↑, TumCP↓, eff↓, Glycolysis↓,

2593-

Api,

Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo

-

in-vivo,

BC,

4T1

4T1 xenograft tumor mouse model

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↑, ROS↑, p‑PI3K↓, PI3K↓, Akt↓, NRF2↓, AntiTum↑, OS↑,

5133-

ART/DHA,

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

U251

AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP/DDIT3↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,

2571-

ART/DHA,

Cancer combination therapies with artemisinin-type drugs

-

Review,

Var,

NA

AntiTum↑, ChemoSen↑, hepatoP↝,

5169-

Ash,

The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

-

in-vitro,

BC,

MCF7

AntiTum↑, angioG↓, Vim↓,

5175-

Ash,

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

-

in-vitro,

Cerv,

CCL-102

Inflam↓, AntiTum↑, Proteasome↓, ER Stress↑, HSPs↑, GRP94↑, Akt↑, eff↑, HSP70/HSPA5↑,

4678-

Ash,

Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer

-

vitro+vivo,

NSCLC,

H1975

ROS↑, AntiTum↑, CSCs↓, mTOR↓, STAT3↓, ChemoSen↑, Keap1↑, NRF2↓,

4819-

ASTX,

Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway

-

in-vitro,

BC,

MCF7

5, 10, 25, 50, 75, 100, 125, and 150 μg/mL)

IC50 = 89.742 μg/mL

antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,

4804-

ASTX,

Astaxanthin in cancer therapy and prevention (Review)

-

Review,

Var,

NA

-

Review,

AD,

NA

*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, eff↑, AntiTum↑,

5424-

ASTX,

Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity

-

in-vivo,

Nor,

NA

mice

*GutMicro↑, AntiCan↑, eff↑, AntiTum↑, ChemoSen↑,

5448-

ATV,

Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology

-

Review,

Var,

NA

Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,

5364-

AV,

A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application

-

Review,

Var,

NA

BioAv↑, AntiTum↑, cardioP↑,

5365-

AV,

Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications

-

Review,

Nor,

NA

-

Review,

IBD,

NA

-

Review,

Diabetic,

NA

*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,

5577-

B-Gluc,

Lentinan progress in inflammatory diseases and tumor diseases

-

Review,

Var,

NA

-

Review,

IBD,

NA

AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,

5580-

B-Gluc,

Lentinan, a Shiitake Mushroom β-Glucan, Downregulates the Enhanced PD-L1 Expression Induced by Platinum Compounds in Gastric Cancer Cells

-

in-vitro,

GC,

MKN45

PD-L1↓, MAPK↓, OS↑, AntiTum↑, Imm↑,

876-

B-Gluc,

Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future

-

Review,

NA,

NA

AntiTum↑,

5251-

Ba,

The Fascinating Effects of Baicalein on Cancer: A Review

-

Review,

Var,

NA

AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,

2022-

BBR,

GoldNP,

Rad,

Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

-

in-vitro,

Liver,

SMMC-7721 cell

-

in-vitro,

Nor,

HL7702

*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,

2674-

BBR,

Berberine: A novel therapeutic strategy for cancer

-

Review,

Var,

NA

-

Review,

IBD,

NA

Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,

6503-

BCP,

The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer

-

Review,

Var,

NA

ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,

5584-

BetA,

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors

-

in-vitro,

GBM,

A172

-

in-vitro,

GBM,

U118MG

-

in-vitro,

GBM,

U251

Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,

2724-

BetA,

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice

-

in-vivo,

Nor,

NA

mice

-

in-vivo,

Stroke,

NA

AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,

2760-

BetA,

A Review on Preparation of Betulinic Acid and Its Biological Activities

-

Review,

Var,

NA

-

Review,

Stroke,

NA

AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,

5718-

BF,

Bufalin inhibits CYP3A4 activity in vitro and in vivo

-

in-vivo,

Nor,

NA

Wistar rats

CYP3A4↓, Apoptosis↑, AntiTum↑,

5628-

Bif,

immuno,

Bifidobacterium modulation of tumor immunotherapy and its mechanism

-

Review,

Var,

NA

Imm↑, Risk↓, GutMicro↑, AntiTum↑, OS↑, selectivity↑, eff↑,

5629-

Bif,

ProBio,

Gut microbiota shapes cancer immunotherapy responses

-

Review,

Var,

NA

eff↑, DCells↑, CD8+↑, eff↑, AntiTum↑, other↑, selectivity↑, GutMicro↑,

5686-

BJ,

BRU,

A review of Brucea javanica: metabolites, pharmacology and clinical application

-

Review,

Var,

NA

AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,

5690-

BJ,

BRU,

Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica

-

Review,

Var,

NA

NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,

2024-

Bos,

Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro

-

in-vitro,

BC,

MCF7

 101.1

-

in-vitro,

Nor,

MCF10

275.2

MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,

5702-

BRU,

BJ,

Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming

-

in-vitro,

BC,

NA

AntiTum↑, PPP↓, Glycolysis↓, TCA↓, NADPH↓, ROS↑, chemoP↑, e-LDH↑, TumMeta↓, Glycolysis↓,

2047-

Buty,

Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells

-

in-vitro,

CRC,

T24/HTB-9

0-10mM

-

in-vitro,

Nor,

SV-HUC-1

-

in-vitro,

Bladder,

5637

-

in-vivo,

NA,

NA

200 mg/kg/day, i.g., n = 5

mice

HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,

1205-

Caff,

immuno,

Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody

-

in-vivo,

Melanoma,

B16-F10

OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,

2012-

CAP,

Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways

-

NA,

OS,

MG63

0-40 μM

20 μM

AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,

2017-

CAP,

Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease

-

Review,

Var,

NA

RenoP↑, AntiTum↑, AMPK↑, mTOR↑, PD-1↓, PD-L1↓,

2020-

CAP,

Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale

-

Review,

Var,

NA

AntiTum↑, selectivity↑, TRPV1↑, MMP↓, Ca+2↑, ER Stress↑, angioG↓, Casp3?, cl‑PARP↑, selectivity↑, ROS↑, *ROS∅, selectivity↑,

Showing Research Papers: 1 to 50 of 184
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 184

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1, 4-OHE1↓, 1, AntiBio↓, 1, GSTM1↑, 1, HSP60/HSPD1↓, 1, LIMK1↓, 1, NOD1↓, 1, SUMO↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, Copper↓, 1, CYP1A1↑, 1, Ferroptosis↑, 4, GPx4↓, 2, GSH↓, 3, GSH↑, 1, GSH/GSSG↓, 2, GSR↑, 1, GSTs↑, 1, H2O2↑, 2, HO-1↓, 2, HO-1↑, 1, Iron↑, 2, Keap1↑, 1, lipid-P↓, 1, lipid-P↑, 4, MDA↑, 1, NAF1↓, 1, NQO1↓, 1, NQO1↑, 1, NRF2↓, 7, NRF2↑, 5, OXPHOS↑, 2, OXPHOS↝, 1, PARK2↑, 1, ROS?, 2, ROS↓, 3, ROS↑, 60, ROS⇅, 1, i-ROS↑, 1, mt-ROS↑, 2, SOD↓, 2, SOD↑, 2, SOD1↓, 1, Thiols↓, 1, TKT↓, 1, Trx↓, 1, TrxR↓, 2, TrxR1↓, 2, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 5, ATP↓, 4, CDC25↓, 2, EGF↓, 1, MMP↓, 22, MMP↑, 1, mtDam↑, 5, OCR↓, 1, OCR↑, 1, PGC-1α↑, 1, PINK1↑, 1, e-Raf↓, 1, XIAP↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, p‑ACLY↓, 1, ACSL4↑, 1, ALAT↓, 1, ALDOA↓, 1, AMPK↑, 5, p‑AMPK↑, 1, CREB↑, 1, CYP3A4↓, 1, FASN↓, 1, FGF21↓, 1, GLO-I↓, 1, GlucoseCon↓, 3, Glycolysis↓, 10, HK2↓, 3, HMG-CoA↓, 1, lactateProd↓, 2, LDH↓, 1, LDH↑, 1, e-LDH↑, 1, LDL↓, 1, lipidLev↓, 1, lipoGen↓, 1, NADPH↓, 1, PDK3↓, 1, PFKP?, 1, PKM2↓, 2, PPARγ↑, 1, PPP↓, 2, SIRT1↓, 1, SREBP1/SREBF1↓, 2, TCA↓, 2, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 19, Akt↑, 4, p‑Akt↓, 8, APAF1↑, 1, Apoptosis↓, 2, Apoptosis↑, 61, BAD↓, 2, BAD↑, 1, BAX↑, 25, Bax:Bcl2↑, 3, Bcl-2↓, 33, Bcl-xL↓, 6, Casp↑, 8, Casp12↑, 1, cl‑Casp12↑, 1, Casp3?, 1, Casp3↓, 3, Casp3↑, 24, cl‑Casp3↑, 6, Casp6↓, 1, Casp7↑, 3, Casp8↓, 1, Casp8↑, 3, Casp9↓, 1, Casp9↑, 19, cl‑Casp9↑, 2, cFLIP↓, 1, Cyt‑c↑, 17, DR5↑, 2, DR5↝, 1, FADD↑, 1, Fas↓, 1, Fas↑, 3, FasL↓, 1, FasL↑, 2, Ferroptosis↑, 4, GSDME↑, 1, IAP1↓, 1, iNOS↓, 3, JNK↓, 2, JNK↑, 4, p‑JNK↑, 1, MAPK↓, 9, MAPK↑, 5, Mcl-1↓, 3, MDM2↓, 1, MOMP↑, 1, Myc↓, 1, p27/CDKN1B↑, 3, p38↓, 1, p38↑, 1, p‑p38↓, 1, p‑p38↑, 1, Proteasome↓, 1, pS2/TFF1↓, 1, Pyro↑, 1, survivin↓, 3, TRAIL⇅, 1, TRAILR↑, 1, TRPV1↑, 2, TumCD↑, 8,

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1, Sp1/3/4↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1, other↓, 2, other↑, 2, other↝, 6, PhotoS↑, 1, tumCV↓, 13,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 2, CHOP/DDIT3↝, 1, eIF2α↑, 2, p‑eIF2α↓, 1, ER Stress↑, 8, GRP78/BiP↓, 1, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↑, 2, HSP90↓, 1, HSPs↑, 1, IRE1↑, 1, PERK↑, 3, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 2, MitoP↓, 1, p62↓, 1, TumAuto↑, 13,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, CYP1B1↓, 1, DNAdam↓, 1, DNAdam↑, 8, DNArepair↓, 2, P53↓, 3, P53↑, 13, p53 Wildtype↓, 1, PARP↑, 1, cl‑PARP↑, 11, PCNA↓, 1, PCNA↑, 1, γH2AX↑, 2, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3, CDK4↓, 3, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 4, cycD1/CCND1↓, 10, cycE/CCNE↓, 3, P21↑, 7, RB1↑, 1, Securin↓, 1, TBX3↑, 1, TumCCA?, 1, TumCCA↓, 1, TumCCA↑, 35,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2, BMI1↓, 1, CD133↓, 1, CD44↓, 3, CSCs↓, 7, CSCs↑, 1, Diff↑, 2, EMT↓, 14, EMT↑, 1, ERK↓, 7, ERK↑, 1, p‑ERK↓, 3, FGF↓, 1, GSK‐3β↓, 1, GSK‐3β↑, 1, GTPBP4↓, 1, HDAC↓, 4, HDAC1↓, 1, HH↓, 1, HMGCR↓, 1, HOXB-AS1↓, 1, IGF-1R↓, 1, mTOR↓, 13, mTOR↑, 3, p‑mTOR↓, 1, mTORC1↓, 1, Nanog↓, 1, NOTCH↓, 2, NOTCH1↓, 2, NOTCH3↓, 1, OCT4↓, 1, PDGFRB↓, 1, PI3K↓, 12, PI3K↑, 1, p‑PI3K↓, 2, PTEN↑, 3, RAS↓, 2, Shh↓, 1, Smo↓, 1, SOX2↓, 1, STAT3↓, 5, STAT3↑, 1, p‑STAT3↑, 1, TOP1↓, 1, TumCG↓, 38, TumCG↑, 1, Wnt↓, 2,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, APC↑, 1, CA↓, 1, Ca+2↑, 7, Ca+2↝, 2, i-Ca+2↑, 1, cal2↑, 1, CCN2/CTGF↓, 1, CD31/PECAM-1↓, 2, Cofilin↓, 1, E-cadherin↑, 11, FAK↓, 1, p‑FAK↓, 1, Ki-67↓, 6, LEF1↓, 1, miR-133a-3p↑, 1, miR-139-5p↑, 1, miR-19b↓, 1, MMP1↓, 1, MMP13↓, 2, MMP2↓, 16, MMP3↓, 2, MMP7↓, 1, MMP9↓, 17, MMP9↑, 1, MMPs↓, 4, MUC1↑, 1, N-cadherin↓, 8, PAK1↓, 1, PKCδ↓, 1, Rho↓, 1, ROCK1↓, 2, Smad1↑, 1, Snail↓, 1, TGF-β↓, 1, TGF-β↑, 1, TGF-β1↓, 1, TIMP1↑, 3, TIMP2↑, 2, TumCI?, 1, TumCI↓, 22, TumCMig↓, 23, TumCP↓, 32, TumCP↑, 2, TumCP⇅, 1, TumMeta↓, 22, TumMeta↑, 2, Twist↓, 1, uPA↓, 1, VCAM-1↓, 1, Vim↓, 7, Zeb1↓, 1, ZEB2↓, 1, β-catenin/ZEB1↓, 5, β-catenin/ZEB1↑, 1, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22, ATF4↑, 3, EGFR↓, 6, EPR↑, 3, HIF-1↓, 1, Hif1a↓, 7, HIF2a↓, 1, TAMS↑, 1, VEGF↓, 14, VEGFR2/KDR/Flk1↓, 4,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, CTR1↑, 1, P-gp/ABCB1↓, 7,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD4+↓, 1, CD4+↑, 2, COX2/PTGS2↓, 9, DCells↑, 1, HMGB1↓, 1, ICAM-1↓, 1, IFN-γ↑, 2, p‑IKKα↓, 1, IL1↓, 1, IL1β↓, 1, IL1β↑, 2, IL6↓, 6, IL8↓, 2, IL8↑, 1, Imm↑, 9, Imm↝, 1, Inflam↓, 13, JAK2↓, 1, Macrophages↓, 1, MCP1/CCL2↓, 3, Neut↓, 1, NF-kB↓, 24, NK cell↑, 3, p65↓, 1, PD-1↓, 1, PD-L1↓, 3, PGE2↓, 2, T-Cell↑, 2, TLR4↓, 2, TNF-α↓, 4, TNF-α↑, 3,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8, BioAv↑, 9, BioAv↝, 1, chemoR↓, 1, ChemoSen↑, 41, ChemoSen⇅, 1, DDS↑, 1, Dose?, 1, Dose↑, 2, Dose↝, 19, Dose∅, 1, eff↓, 9, eff↑, 55, eff↝, 2, Half-Life↓, 1, Half-Life↑, 1, Half-Life↝, 3, MDR1↑, 1, MRP1/ABCC1↓, 2, P450↓, 1, RadioS↑, 13, selectivity↓, 1, selectivity↑, 25,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, BMPs↑, 1, EGFR↓, 6, GutMicro↑, 6, IL6↓, 6, Ki-67↓, 6, LDH↓, 1, LDH↑, 1, e-LDH↑, 1, Myc↓, 1, PD-L1↓, 3,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13, AntiDiabetic↑, 1, antiNeop↑, 1, AntiP↑, 1, AntiTum↑, 184, cardioP↑, 3, chemoP↑, 12, chemoPv↑, 4, cognitive↑, 1, fatigue↓, 1, hepatoP↑, 2, hepatoP↝, 1, neuroP↑, 3, OS↑, 15, Pain↓, 2, QoL↑, 4, radioP↑, 5, RenoP↑, 3, Risk↓, 7, toxicity↓, 4, toxicity↑, 4, toxicity↝, 6, toxicity∅, 3, TumVol↓, 6, TumVol↑, 1, TumW↓, 4, Weight↑, 2, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1, Bacteria↓, 3, CD8+↑, 4, Sepsis↓, 3,
Total Targets: 430

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1, diuretic↑, 2, Ingr?, 1, P-sel↓, 1, Stroke↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 28, Catalase↑, 5, Ferroptosis↓, 1, GPx↑, 6, GPx4↑, 1, GSH↑, 5, GSTs↑, 2, H2O2↓, 2, HDL↑, 2, HNE↓, 1, HO-1↓, 1, HO-1↑, 4, Keap1↓, 1, lipid-P↓, 6, MDA↓, 3, NADH↓, 1, NOX4↓, 2, NQO1↑, 1, NRF2↑, 7, RNS↓, 1, ROS↓, 21, ROS↑, 1, ROS∅, 2, selenoP↑, 2, SOD↑, 8, SOD1↑, 1, TAC↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1, AMPK↑, 1, glucose↓, 2, glucose↝, 1, GLUT2↑, 1, HMG-CoA↓, 1, LDH↓, 2, LDL↓, 2, PPARγ↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3, Casp3↓, 1, Casp9↓, 1, Fas↓, 1, Ferroptosis↓, 1, HGF/c-Met↑, 1, iNOS↓, 1, MAPK↓, 3,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, other?, 1, other↓, 3, other↑, 1, other↝, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1, GRP78/BiP↑, 1, GRP94↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1, STAT3↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 1, AntiAg↑, 3, TIMP1↓, 1, ZO-1↑, 2, α-SMA↓, 1, α-tubulin↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, Hif1a↑, 1, NO?, 1, NO↓, 3,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, GastroP↑, 2, IBI↑, 1, OCLN↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1, COX1↑, 1, COX2/PTGS2↓, 3, ICAM-1↓, 1, IL10↑, 1, IL1β↓, 5, IL6↓, 4, Imm↑, 8, Inflam↓, 39, Inflam↑, 1, JAK↓, 1, MCP1/CCL2↓, 1, NF-kB↓, 7, NK cell↑, 1, PGE2↓, 2, TLR2↓, 1, TLR4↓, 4, TNF-α↓, 6, TNF-α↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3, BChE↓, 1, GABA↑, 1, GABA↝, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 4, NLRP3↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3, BioAv↑, 11, BioAv↝, 8, BioEnh↑, 1, Dose↝, 1, eff↑, 6, Half-Life↓, 1, Half-Life↝, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, BP↓, 2, GutMicro↑, 5, IL6↓, 4, LDH↓, 2, NOS2↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3, AntiCan↑, 2, AntiDiabetic↑, 10, AntiP↓, 1, AntiP↑, 3, AntiTum↑, 1, cardioP↑, 7, chemoPv↑, 1, cognitive↑, 2, hepatoP↑, 6, memory↑, 1, neuroP↑, 12, Obesity↓, 3, radioP↑, 2, RenoP↑, 3, Risk↓, 1, toxicity↓, 17, toxicity↑, 3, toxicity↝, 2, toxicity∅, 1, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2, AntiViral↑, 3, Bacteria↓, 14, Sepsis↓, 1,
Total Targets: 143

Scientific Paper Hit Count for: AntiTum, AntiTumor

6 chitosan
6 Selenite (Sodium)
5 Silver-NanoParticles
5 immunotherapy
4 Chlorogenic acid
4 Ivermectin
4 Licochalcone A
4 Quercetin
4 Resveratrol
4 Selenium NanoParticles
3 Astragalus
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 beta-glucans
3 Radiotherapy/Radiation
3 Betulinic acid
3 Brucea javanica
3 brusatol
3 Capsaicin
3 Copper and Cu NanoParticles
3 Disulfiram
3 Isoliquiritigenin
3 Gambogic Acid
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Hydrogen Gas
3 Vitamin C (Ascorbic Acid)
3 Inulin Prebiotic
3 Spermidine
2 1,8-Cineole
2 Auranofin
2 Cisplatin
2 Artemisinin
2 Aloe anthraquinones
2 Berberine
2 Bifidobacterium
2 Carvacrol
2 Chlorophyllin
2 Gemcitabine (Gemzar)
2 Cucurbitacin
2 D-limonene
2 Formononetin
2 Gallic acid
2 Indole-3-carbinol
2 Inositol
2 iodine
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Kaempferol
2 Magnolol
2 Naringin
2 Psoralidin
2 α-Santalol/Sandalwood oil
2 Shikonin
2 Thymol-Thymus vulgaris
1 3-bromopyruvate
1 acetazolamide
1 Allicin (mainly Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Baicalein
1 Gold NanoParticles
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 probiotics
1 Boswellia (frankincense)
1 Butyrate
1 Caffeine
1 Carnosine
1 Celastrol
1 Prebiotic
1 Choline
1 Cinnamon
1 Camptothecin
1 Carvone
1 Cyclopamine
1 Cynaropicrin
1 Deguelin
1 Dandelion Root
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Evodiamine
1 Ferulic acid
1 Fucoidan
1 Ginkgolic acids
1 Geldanamycin
1 Geraniol
1 HydroxyTyrosol
1 Hyperoside
1 Paclitaxel/Taxol
1 capecitabine
1 Lactobacillus
1 Licorice
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Methylene blue
1 Honokiol
1 Melatonin
1 Magnetic Fields
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 Oxygen, Hyperbaric
1 Phenylbutyrate
1 Piperlongumine
1 Polyphenols
1 Pterostilbene
1 Curcumin
1 Radio Frequency
1 salinomycin
1 Selenium
1 Chemotherapy
1 Sulforaphane (mainly Broccoli)
1 erastin
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 tetrathiomolybdate
1 Turmerones
1 Urolithin
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:913  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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