SIRT3 Cancer Research Results

SIRT3, Sirtuin 3: Click to Expand ⟱
Source:
Type:
SIRT3 (Sirtuin 3) is a protein that is a member of the sirtuin family of proteins, which are involved in various cellular processes, including metabolism, stress resistance, and longevity.
In general, low SIRT3 expression is associated with:
-Poor prognosis, Increased tumor size, Metastasis, Resistance to chemotherapy and radiation therapy, Poor response to treatment.
High SIRT3 expression is associated with:
-Better prognosis, Smaller tumor size, Less metastasis, Better response to chemotherapy and radiation therapy, Better response to treatment.
SIRT3 also functions as a tumor suppressor by targeting the mitochondrial enzyme manganese superoxide dismutase (MnSOD), decreasing reactive oxygen species (ROS) production and maintaining genomic stability.
Scientific Papers found: Click to Expand⟱
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2899- HNK,    SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus
- in-vivo, Nor, NA
*memory↑, *Inflam↓, *ROS↓, neuroP↑, SIRT3↑, ac‑SOD2↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
2900- HNK,    The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance
- Review, Var, NA
SIRT3↑, Hif1a↓, ChemoSen↑, chemoP↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
968- OA,    Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MBT-2
Hif1a↓, SIRT3↑, SOD2↑, GlucoseCon↓, Glycolysis↓, TumCG↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GSR↑, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↑, 6,   SIRT3↑, 12,   SOD2↑, 1,   ac‑SOD2↓, 1,   TKT↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   MEK↓, 1,   mitResp↓, 1,   MKK4↓, 1,   MMP↓, 2,   Raf↓, 1,   c-Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 1,   G6PD↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PDH↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 1,   PPARα↓, 1,   R5P↝, 1,   SIRT1↑, 3,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 2,   mt-Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   BMP2↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp6↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Chk2↓, 1,   Cyt‑c↑, 1,   DR5↑, 1,   Ferroptosis↑, 1,   HEY1↓, 1,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 1,   Mcl-1↑, 1,   p38↓, 1,   p38↑, 2,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   EZH2↓, 1,   H3↑, 2,   H4↑, 1,   HATs↑, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP90↓, 1,   HSPs↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 2,   P21?, 1,   P21↑, 1,   p‑RB1↓, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 2,   EMT↓, 4,   p‑ERK↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 3,   SOX2↓, 1,   STAT3↓, 2,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   E-cadherin↑, 1,   ER-α36↓, 1,   F-actin↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 3,   MMPs↓, 2,   N-cadherin↓, 2,   Slug↓, 1,   Snail↓, 2,   SOX4↓, 1,   talin↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 2,   uPA↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 5,   PDGFR-BB↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   IKKα↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   p‑NF-kB↓, 1,   p65↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 3,   Dose↝, 1,   eff↓, 1,   eff↑, 6,   Half-Life↓, 1,   Half-Life↝, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 2,   EZH2↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 1,  
Total Targets: 181

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx1↑, 1,   GPx4↑, 1,   NRF2↑, 1,   Prx↑, 1,   ROS↓, 3,   SOD1↑, 1,   SOD2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Casp3?, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,   toxicity?, 1,   toxicity↓, 2,  
Total Targets: 18

Scientific Paper Hit Count for: SIRT3, Sirtuin 3
5 Honokiol
1 Ashwagandha(Withaferin A)
1 Carvacrol
1 Magnetic Fields
1 Myricetin
1 Oroxylin-A
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:934  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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