PFK1 Cancer Research Results

PFK1, Phosphofructokinase-1: Click to Expand ⟱
Source:
Type:
Phosphofructokinase-1 (PFK1) is a key regulatory enzyme in glycolysis that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.
– As a rate-limiting enzyme in glycolysis, PFK1 is subject to complex regulation through allosteric effectors including ATP, AMP, and fructose-2,6-bisphosphate.
• Metabolic Control:
–PFK1 activity is central to controlling the pace of glycolysis, thereby influencing energy production and intermediary metabolite supply.
– In highly proliferative cells or cells under growth conditions, increased glycolytic flux (and, by extension, PFK1 activity) supports the biosynthetic demands of cell division.

– Many tumors (including breast, colorectal, and lung cancers) have been reported to have increased PFK1 expression/activity relative to normal tissues.
– High glycolytic flux, driven partly by enhanced PFK1, supports rapid cell proliferation and survival in the nutrient/stress-challenged tumor microenvironment.

Inhibitors:(typically glycolysis is targeted more broadly)
-Citrate
-Hydrogen ions (pH) – Acidic conditions can have inhibitory effects.
-3PO: inhibits PFKFB3, thereby indirectly reducing PFK1 activity.
-Resveratrol can downregulate glycolytic flux in cancer cells, which may indirectly affect PFK1 activity.
- FMDs offer an indirect strategy to modulate cancer metabolism by broadly reducing glycolysis. Their impact on PFK1 is likely part of a complex network of metabolic adaptations rather than a direct inhibitory effect.
Scientific Papers found: Click to Expand⟱
8740- MGO,    Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation
- in-vitro, Liver, HepG2
GLO-I↓, HAGH/GLO2↓, RAGE↑, AGEs↑, Hypoxia↑, ROS↑, GlucoseCon↑, GLUT1↑, HK2↑, PFK1↑, LDH↑, lactateProd↑, Glycolysis↑, Hif1a↑, Warburg↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GLO-I↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   HAGH/GLO2↓, 1,   HK2↑, 1,   lactateProd↑, 1,   PFK1↑, 1,   Warburg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,   Hypoxia↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

RAGE↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,   RAGE↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PFK1, Phosphofructokinase-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:988  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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