PPARα Cancer Research Results

PPARα, Peroxisome Proliferator-Activated Receptor Alpha: Click to Expand ⟱
Source:
Type:
• PPARα
– Regulates fatty acid oxidation, lipid metabolism, and energy homeostasis.
– Expressed primarily in liver, heart, kidney, and muscle, PPARα activation induces genes involved in β-oxidation and lipid transport.
– It is also involved in modulating inflammatory responses, which may indirectly affect cellular proliferation and survival.

– Expression and activation in cancers can vary:
– In some liver cancers, PPARα expression or activity may be altered, reflecting its central role in hepatic metabolism.
– Overactivation has been associated with liver proliferation in rodent models; however, species differences exist regarding the carcinogenic potential of PPARα agonists.
– Outside the liver, PPARα’s role is less defined, but its regulation of inflammation and lipid metabolism may influence tumor metabolism and microenvironment.
Scientific Papers found: Click to Expand⟱
1082- CAR,    Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression
- in-vitro, lymphoma, U937
COX2/PTGS2↓, PPARα↑, PPARγ↑,
8198- LGE,    Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression
- in-vitro, Var, NA
COX2/PTGS2↓, PPARα↑, PPARγ↑,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FABP4↑, 1,   PPARα↑, 3,   PPARγ↑, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Cyt‑c↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   Gli1↓, 1,   IGFBP3↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PPARα, Peroxisome Proliferator-Activated Receptor Alpha
1 Carvacrol
1 Lemongrass Extract/Citral
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:993  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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