toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
5281- 3BP,    A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- Case Report, Var, NA
Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, eff↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
4428- AgNPs,    p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells
- in-vitro, AML, Jurkat
toxicity↝, tumCV↓, ROS↑, p38↑, NRF2↓, NF-kB↝, DNAdam↑, Apoptosis↑,
4430- AgNPs,    Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells
- in-vitro, Colon, HCT116 - in-vitro, Nor, NCM460
*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,
391- AgNPs,    Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells
- in-vitro, Nor, NA
*VEGF↓, *IL1↓, toxicity↝, other↝,
5394- Ash,    Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial
- Trial, OS, NA
toxicity↝, hepatoP↓, BioAv↓, Apoptosis↑, ROS↑, TumCCA↑,
5387- AsP,  PacT,    Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy
- in-vivo, Melanoma, B16-F10
Dose↝, TumCG↓, TumCP↓, BioAv↓, BioAv↑, other↑, Apoptosis↑, Bax:Bcl2↑, EPR↑, toxicity↝,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
5589- BetA,    Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy
- Review, Var, NA
BioAv↓, toxicity↝, BioAv↑, Half-Life↑,
5690- BJ,  BRU,    Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica
- Review, Var, NA
NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27/CDKN1B↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,
5682- BML,    A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study
- Human, Var, NA
Dose↝, toxicity↝, eff↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
7975- BUL,    Bullatacin--in vivo and in vitro experience in an ovarian cancer model
- in-vitro, Ovarian, OVCAR-3
toxicity↝, TumCD↑,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, eff↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5829- CAP,    Anti-cancer activity of capsaicin and its analogs in gynecological cancers
- Review, Var, NA
Pain↓, BioAv↓, toxicity↝, toxicity↓,
5844- CAP,    Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers
- in-vitro, Lung, DMS114
eff↑, AMPK↑, toxicity↝, BioAv↑, TRPV1↑, TumCI↓,
5862- carbop,  Cisplatin,    Molecular Mechanisms of Resistance and Toxicity Associated with Platinating Agents
- Review, Var, NA
DNAdam↑, ER Stress↑, UPR↑, ATF4↑, ATF6↑, XBP-1↑, GRP78/BiP↑, NP/CIPN↝, toxicity↝, eff↑, TrxR1⇅,
5929- Catechins,    Phase I trial of oral green tea extract in adult patients with solid tumors
- Trial, Var, NA
Dose↑, toxicity↝,
5917- Cats,    Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
- Trial, CRC, NA
Dose↝, *DNArepair↑, toxicity↝, BioAv↝, eff∅,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
6371- CPLE,    Carica papaya L. Leaf: A Systematic Scoping Review on Biological Safety and Herb-Drug Interactions
- Review, Nor, NA
eff↓, toxicity↝,
6170- Cu,    Copper induces cell death by targeting lipoylated TCA cycle proteins
- in-vitro, Var, NA
TCA↓, toxicity↝, Cupro↑,
6196- Cuc,    Cucurbitacins – A Promising Target for Cancer Therapy
- Review, Var, NA
STAT3↓, toxicity↝, COX2/PTGS2↓, TumCG↓, TumCCA↑, Apoptosis↑, STAT3↓, JAK2↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
6240- CUSP9,    A Pilot Clinical Study of CUSP9v3: Nine Repurposed Drugs Combined With Temozolomide for the Treatment of Recurrent Glioblastoma
- Human, GBM, NA
toxicity↝,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6678- DCA,  Cisplatin,    Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma
- Trial, HNSCC, NA
PDK1 / PDPK1↓, OS∅, lactateProd↓, toxicity↝, FAO↑,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2/PTGS2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp/ABCB1↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,
7124- Ge-132,    Physiological Activity of Trace Element Germanium including Anticancer Properties
- Review, Var, NA
*toxicity↓, Risk↓, Dose↝, AntiCan↑, AntiTum↑, Inflam↓, OXPHOS↝, *toxicity↓, *toxicity↓, other↑, eff↑, *Bacteria↓, *AntiFungal↑, eff↑, eff↑, ROS↑, eff↑, toxicity↝, *H2O2↓, *ROS↓, Warburg↓,
7112- GEO2,    Hazard assessment of germanium supplements
- Review, Var, NA
toxicity↝, RenoP↓, NP/CIPN↑, Dose↝,
7115- GeS,    A phase II study of spirogermanium as second line therapy in patients with poor prognosis lymphoma. An NCI Canada Clinical Trials Group Study
- Trial, lymphoma, NA
eff↓, toxicity↝,
7305- GoldNP,  Rad,    The use of gold nanoparticles to enhance radiotherapy in mice
- in-vivo, Var, NA
Dose↝, selectivity↑, toxicity↝, RadioS↑,
7304- GoldNP,    Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine
Dose↝, toxicity↝, Dose↑,
7320- Gos,    AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma
- Trial, Melanoma, NA
Bcl-2↓, Mcl-1↓, Apoptosis↑, eff↑, toxicity↝, ORR↑,
7316- Gos,  PacT,  carbop,  Chemo,    A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors
- Trial, Var, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, Dose↝, toxicity↝,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7134- GSL,    Phase I study of oral spirogermanium
- Trial, NA, NA
*Dose↝, toxicity↝, Bil∅, toxicity↝, Dose↓,

Showing Research Papers: 1 to 50 of 75
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 75

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CR↑, 1,   DCR↑, 1,   EFS↑, 1,   IGF-2R↑, 1,   miR-106b↓, 1,   miR-375↑, 1,   OGFr↑, 1,   ORR↑, 1,   PFS↑, 1,   PGI2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Bil∅, 1,   Catalase↑, 1,   compI↓, 1,   GSH↓, 1,   GSTZ1↓, 1,   H2O2↑, 1,   HO-1↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 2,   PARK2↑, 1,   ROS↓, 1,   ROS↑, 27,   SOD↓, 1,   SOD↑, 1,   Thiols↓, 1,   TrxR↓, 1,   TrxR1⇅, 1,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 5,   Insulin↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 6,   MPT↑, 1,   mtDam↑, 4,   OCR↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   CREB↓, 1,   FAO↑, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   GlutaM↓, 1,   Glycolysis↓, 7,   HK2↓, 2,   HMG-CoA↓, 1,   lactateProd↓, 5,   LDH↓, 1,   LDHA↓, 2,   lipoGen↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDK1 / PDPK1↓, 3,   PDKs↓, 1,   PKM2↓, 1,   SIRT1↓, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 19,   ATF2↓, 1,   BAX↑, 8,   Bax:Bcl2↑, 2,   Bcl-2↓, 10,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 4,   Casp3↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 3,   proCasp3↓, 1,   cl‑Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 2,   Cupro↑, 1,   Cyt‑c↑, 6,   DR5↑, 1,   iNOS↓, 1,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 3,   MCT1↓, 1,   Myc↓, 1,   necrosis↑, 2,   p27/CDKN1B↑, 2,   p38↑, 1,   p‑p38↑, 2,   Paraptosis↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TRPV1↑, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   cJun↑, 1,   HATs↑, 1,   other↑, 2,   other↝, 9,   other∅, 1,   PhotoS↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP90↓, 2,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   DNArepair↑, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 3,   p53 Wildtype↓, 1,   PARP↑, 3,   cl‑PARP↑, 4,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD44↓, 1,   CIP2A↓, 1,   CSCs↓, 4,   CSCs↑, 1,   Diff↑, 1,   EIF4E↓, 1,   EMT↓, 7,   ERK↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HH↓, 3,   IGF-1↑, 1,   IGFBP3↑, 1,   mTOR↓, 7,   mTOR↑, 1,   p‑mTOR↓, 1,   mTORC1↓, 1,   NOTCH↓, 2,   PI3K↓, 10,   PTEN↑, 2,   Smo↓, 1,   STAT3↓, 6,   STAT3↑, 1,   TumCG↓, 13,   TumCG↑, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

CA↓, 1,   Ca+2↑, 2,   Ca+2↝, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 4,   FAK↓, 1,   FAK↑, 1,   GLI3↓, 1,   Ki-67↓, 2,   miR-19b↓, 2,   miR-203↑, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 4,   N-cadherin↓, 2,   PDGF↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 13,   TumCP↑, 1,   TumMeta↓, 4,   Twist↓, 1,   uPA↓, 1,   Vim↓, 4,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   angioG↑, 1,   ATF4↑, 2,   EGFR↓, 2,   Endoglin↓, 1,   EPR↑, 1,   Hif1a↓, 5,   VEGF↓, 4,   VEGFR2/KDR/Flk1↓, 3,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   GLUT1↓, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 3,   sonoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   IL1↓, 1,   Imm↑, 2,   Inflam↓, 3,   JAK2↓, 2,   NF-kB↓, 7,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 13,   BioAv↝, 3,   BioEnh↑, 2,   ChemoSen↑, 18,   Dose↓, 2,   Dose↑, 6,   Dose↝, 24,   eff↓, 9,   eff↑, 39,   eff↝, 2,   eff∅, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 8,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   RadioS↑, 9,   selectivity↑, 10,   selectivity↝, 1,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BG↓, 1,   Bil∅, 1,   CA125↓, 1,   CA125∅, 1,   CTC↓, 1,   EGFR↓, 2,   Ferritin↓, 1,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↓, 1,   AntiTum↑, 5,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   NP/CIPN↑, 1,   NP/CIPN↝, 1,   OS↑, 6,   OS∅, 1,   Pain↓, 1,   QoL↑, 3,   QoL∅, 2,   Remission↑, 1,   RenoP↓, 1,   Risk↓, 3,   Risk↑, 1,   Risk∅, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 80,   toxicity∅, 2,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 302

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   ARE↑, 1,   Catalase↑, 1,   GPx↑, 1,   H2O2↓, 1,   HO-1↑, 3,   lipid-P↓, 1,   NQO1↑, 1,   NRF2↑, 3,   OXPHOS↑, 1,   ROS↓, 4,   SOD↑, 2,   SOD1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Fas↓, 1,   FasL↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1↓, 1,   IL10↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 9,   IκB?, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Dose↝, 2,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↓, 3,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   Sepsis↓, 1,  
Total Targets: 55

Scientific Paper Hit Count for: toxicity, toxicity
6 itraconazole
5 Silver-NanoParticles
5 Selenite (Sodium)
4 3-bromopyruvate
3 Dichloroacetate
2 Paclitaxel/Taxol
2 Capsaicin
2 carboplatin
2 Cisplatin
2 Copper and Cu NanoParticles
2 Cucurbitacin
2 salinomycin
2 Diclofenac
2 Radiotherapy/Radiation
2 Disulfiram
2 Gold NanoParticles
2 Gossypol/AT-101
2 Ramucirumab (CYRAMZA)
1 Auranofin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Baicalein
1 Baicalin
1 doxorubicin
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Bromelain
1 borneol
1 Bullatacin
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Carica papaya leaf extract
1 CUSP9
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 immunotherapy
1 Zinc
1 Emodin
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Germanium inorganic
1 Germanium-Spirogermanium
1 Chemotherapy
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Ivermectin
1 Juglone
1 Lapatinib
1 Trastuzumab
1 low dose naltrexone
1 Licorice
1 Methyl Jasmonate
1 Bicarbonate(Sodium)
1 Pterostilbene
1 SonoDynamic Therapy UltraSound
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1025  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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