2/16-OHE1 Cancer Research Results

2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio: Click to Expand ⟱

Source:

Type:

2-OHE1/16α-OHE1 Ratio - 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio

Abbreviation: 2/16-OHE1 ratio, 2-OHE1/16α-OHE1, EMR

Type: Estrogen metabolism biomarker / metabolite ratio

Function: Represents the relative metabolism of estrone through the 2-hydroxylation versus 16α-hydroxylation pathways. 2-Hydroxyestrone has relatively weak estrogenic activity, whereas 16α-hydroxyestrone has greater estrogenic and potentially genotoxic/proliferative activity.

Cancer: ↓ A lower 2-OHE1/16α-OHE1 ratio has historically been proposed to represent a less favorable estrogen-metabolism profile and potentially greater breast-cancer risk, while an increased ratio has been considered potentially favorable. However, prospective studies and systematic reviews have found inconsistent associations, and the ratio is not considered a validated predictor of breast-cancer risk.

Direction: ↑ Traditionally considered favorable, but clinical significance remains uncertain.

Scientific Papers found: Click to Expand⟱

8832-

DIM,

Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy

Trial,

Pca,

 double-blind, placebo-controlled trial of DIM in patients diagnosed with prostate cancer and scheduled for radical prostatectomy.

Dose?, *toxicity↓, BioAv↑, 2/16-OHE1↝, eff↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↝, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, Dose?, 1, eff↝, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,
Total Targets: 1

Scientific Paper Hit Count for: 2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells