CEC Cancer Research Results

CEC, Circulating endothelial cells: Click to Expand ⟱
Source:
Type: Biomarker

Circulating Endothelial Cells

Abbreviation: CEC, CECs

Type: Cellular biomarker / endothelial injury marker / vascular and angiogenesis biomarker

Function: Circulating endothelial cells are mature endothelial cells that detach from the vascular endothelium and enter the peripheral blood. They are normally present at very low concentrations, and increased numbers can indicate endothelial injury, vascular dysfunction, inflammation, or increased vascular remodeling.

Cancer: ↑ CEC levels can occur in cancer and may reflect increased endothelial turnover, tumor-associated angiogenesis, vascular injury, or treatment effects. CECs have been investigated as circulating biomarkers of tumor vascular activity and response to antiangiogenic therapies.

Favorable Direction in Cancer: Context-dependent. ↓ elevated CEC levels may indicate reduced tumor-associated vascular turnover or recovery from endothelial injury. However, some anticancer or antiangiogenic therapies can transiently ↑ CECs by damaging tumor vasculature, so treatment-associated changes should be interpreted according to timing and mechanism.

Interpretation Note: Circulating endothelial cells should be distinguished from circulating endothelial progenitor cells (CEPs/EPCs). CECs are predominantly mature endothelial cells shed from existing vessels, whereas endothelial progenitor populations are less differentiated cells associated with vascular repair and neovascularization.

Measurement Note: CEC definitions vary between studies because different flow-cytometry and immunomagnetic marker combinations are used. Reported CEC counts should therefore be interpreted using the specific phenotype and assay defined by the study.
Scientific Papers found: Click to Expand⟱
8418- Lyco,  docx,    A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
- Trial, Pca, NA
Dose↝, BioEnh↑, angioG↓, IGF-1↓, ChemoSen↑, BioAv↑, CEC↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CEC↝, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CEC, Circulating endothelial cells
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1827  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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