BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
305- AgNPs,    Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer
- Case Report, HNSCC, NA
OS↑, Dose↓, BioAv↝, toxicity↓, Remission↑, other↝, other↝, other↝, Dose↝, BioAv↝,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
5497- Ba,    Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
- Review, Var, NA
*Inflam↓, AntiCan↑, BioAv↝, BioAv⇅, BioAv↓, CYP3A2↓, P-gp/ABCB1↓,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2023- BBR,    Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
- in-vitro, Colon, NA - in-vitro, Nor, YAMC
TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,
3867- Bos,    Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers
- Human, Nor, NA
*eff↑, BioAv↝,
5736- Buty,    Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug
- Trial, Var, NA
Dose↝, BioAv↝, toxicity↓, OS↝,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5899- CAR,  TV,    Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, selectivity↑, BioAv↝, BBB↑, *toxicity↝, *antiOx↑, COX2/PTGS2↓, 5LO↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
5917- Cats,    Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
- Trial, CRC, NA
Dose↝, *DNArepair↑, toxicity↝, BioAv↝, eff∅,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
7417- CS,  CGA,    Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans
- Trial, Nor, NA
Dose↝, BioAv↝, Half-Life↝,
6218- CUR,    Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
- Review, Var, NA
NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,
6591- DAS,    Dasatinib in solid tumors
- Review, Var, NA
Src↓, PDGF↓, ABL1↓, BioAv↝, Half-Life↝, Dose↝, eff↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
6782- EGCG,    Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability
- Human, Nor, NA
*Dose↝, BioAv↝, Half-Life↝,
6789- EGCG,    Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?
- Review, Var, NA
BioAv↓, Half-Life↝, Half-Life↝, BioAv↝, *BioAv↑, *BioAv↓, *BioAv↑, *BioAv↑, *Dose↝, *toxicity↝,
6847- EVO,    Evodiamine as an anticancer agent: a comprehensive review on its therapeutic application, pharmacokinetic, toxicity, and metabolism in various cancers
- Review, Var, NA
ChemoSen↑, BioAv↝,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
6979- Form,    Pharmacokinetics and Bioavailability of the Isoflavones Formononetin and Ononin and Their in Vitro Absorption in Ussing Chamber and Caco-2 Cell Models
- in-vitro, Colon, Caco-2
BioAv↝, eff↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
1773- GA,    Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action
- Review, Var, NA
antiOx↑, AntiCan↑, Inflam↓, GutMicro↑, BioAv↝, BioAv↓, BioAv↑, TumMeta↓,
7094- GAR,    A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
- Review, Nor, NA
*Obesity↓, *Appetite↓, *GutMicro↑, BioAv↝,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7337- Gra,    Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer
- in-vitro, Pca, NA
other↝, eff↝, BioAv↝, TumCD↓, TumCG↓, Dose↝, other↝,
7460- HNK,    Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lb MPMs) for Improving Solubility to Enhance Oral Bioavailability
- in-vivo, Nor, NA
BioAv↝, BioAv↝,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
7618- HPT,    ESHO 2-85. Hyperthermia as an adjuvant to radiation therapy in the treatment of advanced neck nodes: A randomized multicenter study by the European Society for Hyperthermic Oncology
ORR↑, NA↑, NA↑, BioAv↝, Dose↝, Dose↝,
7580- I3C,    Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane
- Trial, NA, NA
Dose↝, BioAv↝, Dose↝,
7685- iod,    Could iodine be the missing micronutrient in breast cancer development?
- Review, BC, NA
Risk↓, other↝, other↝, BioAv↝,
7989- itraC,    Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer
- Trial, NSCLC, NA
Dose↝, TumVol↓, angioG↓, IL1β↓, GM-CSF↓, HH∅, BioAv↝, other↝,
8174- Lap,    Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases
EGFR↓, HER2/EBBR2↓, BioAv↝, eff↑, Dose↝,
8171- Lap,    Effects of food on the relative bioavailability of lapatinib in cancer patients
- Trial, Var, NA
BioAv↝, Dose↝,
8163- LapC,    Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
- in-vivo, Arthritis, NA
*DHODH↓, *Imm↓, AntiArt↑, antiPs↑, BioAv↝,
8200- LGE,    Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass
- Review, Var, NA
*AntiBio↑, *antiOx↑, *AntiCan↑, *AntiDiabetic↑, *Inflam↓, Dose↝, BioAv↝,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,

Showing Research Papers: 1 to 50 of 69
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 69

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compII↓, 1,   compV↓, 1,   ERCC3↑, 1,   miR-107↑, 1,   miR-224↓, 1,   miR-422a↑, 1,   MMP16↓, 1,   NA↑, 2,   ORR↑, 1,   PTN↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   compI↓, 2,   Ferroptosis↑, 4,   GPx4↓, 4,   GSH↓, 3,   GSH↑, 1,   GSTs↑, 1,   HK1↓, 1,   HO-1↓, 1,   HO-1↑, 3,   Iron↑, 1,   NRF2↓, 1,   NRF2↑, 3,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 19,   SOD↓, 1,   TrxR↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   ATP↓, 4,   CDC2↓, 1,   compIII↓, 1,   ETC↓, 1,   ETC↑, 1,   MMP↓, 7,   mtDam↑, 3,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 4,   CAIX/CA9↑, 1,   cMyc↓, 3,   cMyc↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   FDG↓, 1,   GAPDH↓, 1,   glucoNG↓, 1,   GlutaM↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDH↑, 1,   PIK3CA↓, 1,   PKM2↓, 1,   PPARγ↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 1,   Apoptosis↑, 17,   BAD↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 6,   Casp1↑, 2,   Casp3↑, 8,   cl‑Casp3↑, 3,   Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 5,   DR5↑, 2,   FasL↑, 1,   Ferroptosis↑, 4,   iNOS↓, 3,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   Mcl-1↓, 1,   MOMP↑, 1,   Myc↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   survivin↓, 5,   Telomerase↓, 1,   TumCD↓, 1,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 2,   HER2/EBBR2↓, 2,   RET↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   EZH2↓, 1,   HATs↓, 1,   miR-21↓, 1,   other↝, 9,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 1,   HSP90↓, 2,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 3,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑CHK1↑, 1,   DNAdam↑, 4,   DNAdamC↑, 1,   DNArepair↓, 1,   DNArepair↑, 1,   DNMT1↓, 2,   MGMT↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 8,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK4↓, 3,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 7,   E2Fs↓, 2,   mitA↑, 1,   P21↓, 1,   P21↑, 3,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD44↓, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 5,   Diff↑, 1,   EMT↓, 7,   ERK↓, 3,   p‑ERK↓, 1,   FOXO1↓, 1,   FOXO1↑, 1,   Gli1↓, 2,   GSK‐3β↑, 1,   HDAC↓, 4,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HH∅, 1,   IGF-1R↓, 1,   LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 1,   mTOR↓, 10,   mTORC1↓, 1,   Nanog↓, 1,   NOTCH↓, 4,   NOTCH1↓, 1,   PI3K↓, 10,   PI3K↝, 1,   PTEN↑, 3,   RAS↓, 2,   Shh↓, 1,   Smo↓, 2,   SOX2↓, 1,   Src↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   TRPM7↓, 1,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 6,   Wnt↝, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AP-1↓, 1,   BACH1↓, 1,   Ca+2↑, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 5,   Ki-67↓, 4,   KRAS↓, 1,   LAMs↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP13↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 8,   MUC4↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   Treg lymp↓, 1,   TumCA↓, 1,   TumCI↓, 8,   TumCMig↓, 4,   TumCP?, 1,   TumCP↓, 10,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   VCAM-1↓, 1,   Vim↓, 3,   Zeb1↓, 2,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 7,   EGR4↓, 1,   HIF-1↓, 1,   Hif1a↓, 4,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 5,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 14,   CXCR4↓, 1,   Dectin1↝, 1,   FOXP3↓, 1,   GM-CSF↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1β↓, 4,   IL6↓, 4,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 2,   JAK1↓, 2,   JAK2↓, 2,   NF-kB↓, 18,   NK cell↑, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE1↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 9,   BioAv⇅, 1,   BioAv↝, 75,   ChemoSen↑, 22,   Dose↓, 1,   Dose↑, 1,   Dose↝, 24,   Dose∅, 1,   eff↓, 1,   eff↑, 21,   eff↝, 4,   eff∅, 1,   Half-Life↓, 3,   Half-Life↝, 10,   MRP1/ABCC1↓, 1,   RadioS↑, 10,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EZH2↓, 1,   Ferritin↓, 1,   GutMicro↑, 2,   GutMicro↝, 1,   HER2/EBBR2↓, 2,   IL6↓, 4,   Ki-67↓, 4,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 9,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 2,   hepatoP↑, 2,   NP/CIPN↓, 1,   OS↑, 2,   OS↝, 1,   radioP↑, 1,   Remission↑, 1,   Risk↓, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 3,   TumVol↓, 4,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Dectin1↝, 1,   Sepsis↓, 2,  
Total Targets: 329

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   DHODH↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↑, 6,   GPx↑, 5,   GSH↑, 7,   GSR↑, 1,   HO-1↓, 1,   Keap1↝, 1,   lipid-P↓, 4,   MDA↓, 3,   NRF2↑, 4,   ROS↓, 13,   ROS∅, 1,   mt-ROS?, 1,   SOD↑, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,   Insulin↑, 2,   MMP↑, 1,   MMP∅, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   H2S↑, 1,   NAD↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   JNK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 1,   other↑, 1,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   COX2/PTGS2↑, 1,   CRP↓, 1,   IL1↓, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 5,   IL6↑, 1,   Imm↓, 1,   Inflam↓, 15,   pol-M2 MC↑, 1,   NF-kB↓, 5,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 8,   BioAv↝, 1,   Dose↝, 4,   eff↑, 4,   Half-Life↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 1,   GutMicro↑, 4,   IL6↓, 5,   IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 4,   antiPs↑, 1,   Appetite↓, 1,   cardioP↑, 6,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 5,   memory↑, 2,   neuroP↑, 9,   Obesity↓, 4,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 113

Scientific Paper Hit Count for: BioAv, bioavailability
3 Allicin (mainly Garlic)
3 Baicalein
3 Carvacrol
3 Chlorogenic acid
3 Niclosamide (Niclocide)
3 Thymoquinone
2 Artemisinin
2 Baicalin
2 Thymol-Thymus vulgaris
2 EGCG (Epigallocatechin Gallate)
2 Formononetin
2 Honokiol
2 Lapatinib
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Ashwagandha(Withaferin A)
1 beta-glucans
1 doxorubicin
1 Berberine
1 Boswellia (frankincense)
1 Butyrate
1 Cat’s Claw
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Curcumin
1 Dasatinib/Phyrago
1 Dandelion Root
1 Disulfiram
1 immunotherapy
1 Evodiamine
1 Fisetin
1 Gallic acid
1 Garcinol
1 Geraniol
1 Ginkgetin
1 Graviola
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 itraconazole
1 Lapachol
1 Lemongrass Extract/Citral
1 Linalool
1 Luteolin
1 Lycopene
1 Methylene blue
1 Melatonin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phenethyl isothiocyanate
1 Cisplatin
1 Quercetin
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
1 cetuximab
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:792  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

Home Page