eff Cancer Research Results

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Scientific Papers found: Click to Expand⟱
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5458- AF,    Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer
- in-vitro, NSCLC, NA
TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,
5468- AF,    The gold complex auranofin: new perspectives for cancer therapy
- Review, Var, NA
TrxR↓, ROS↑, eff↑, Apoptosis↑, TumCG↓, TumCP↓, Akt↓, NF-kB↓, DNAdam↑, eff↝, eff↓, PI3K↓, Akt↓, mTOR↓, Hif1a↓, VEGF↓, Casp3↑, CSCs↓, ATP↓, Glycolysis↓, eff↑, eff↑, MMP↓, AIF↑, toxicity↓,
1903- AgNPs,    Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen
- in-vitro, Lung, U1285
TrxR↓, eff↝, ROS↑,
4421- AgNPs,    Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells
- in-vitro, Cerv, NA
selectivity↑, eff↝, other↝,
4362- AgNPs,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
4554- AgNPs,    Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects
- in-vitro, Cerv, HeLa
Telomerase↓, eff↝,
5147- AgNPs,    Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,
5144- AgNPs,    Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice
- in-vivo, Nor, NA
*DNAdam↑, *toxicity↝, eff↝,
2836- AgNPs,  Gluc,    Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells
- in-vitro, Cerv, HeLa
eff↝, TumCCA↑, eff↑, eff↑, ROS↑, GSH↓, SOD↓, lipid-P↑, LDH↑,
2835- AgNPs,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
5357- almon,    AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations
- Trial, NSCLC, NA
EGFR↓, eff↝, OS↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
5379- ART/DHA,    Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation
Ferritin↓, Iron↑, Fenton↑, lipid-P↑, ChemoSen↑, ROS↑, eff↝,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP/DDIT3↑, DR5↑, Dose↝, BG↓, DNMTs↓,
5362- AV,    Anti-cancer effects of aloe-emodin: a systematic review
- Review, Var, NA
AntiCan↑, eff↝, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumCD↑, MMP↓, ROS↑, Apoptosis↑, CDK1↓, CycB/CCNB1↓, Bcl-2↓, PCNA↓, ATP↓, ER Stress↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, MMP2↓, Ca+2↑, DNAdam↑, Akt↓, PKCδ↓, mTORC2↓, GSH↓, ChemoSen↑,
2612- Ba,  MF,    effect_of_a_static_magnetic_field_and_baicalin_or_baicalein_interactions_on_amelanotic_melanoma_cell_cultures_C32">The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5513- bemA,    ACLY inhibition promotes tumour immunity and suppresses liver cancer
- in-vitro, Liver, NA
ACLY↓, AMPK↑, eff↑, other↝, eff↝,
5583- BetA,    Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells
- vitro+vivo, NA, NA
ROS↑, Bcl-2↓, BAX↑, TOP1↝, eff↝, toxicity↓, toxicity↓, selectivity↑,
5687- BJ,    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
- vitro+vivo, AML, U937
Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,
5475- BM,    The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, Colon, HT29 - in-vitro, Colon, SW48 - in-vitro, Colon, SW-620 - in-vitro, CRC, HCT116
AQPs↓, TumCG↓, TumCCA↓, Apoptosis↑, eff↝,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
2399- CA,  EA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- Review, Col, NA
eff↝, eff↑, Weight↑,
5778- Calc,  VitD3,    Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies
- Study, CRC, NA
Risk↓, eff↝, Risk↓,
5775- Calc,    Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
- Study, CRC, NA
Risk↓, Dose↓, eff↝,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,
6630- CGA,    In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480
tumCV↓, DNAdam↑, mt-ROS↑, MMP↓, Casp3↑, eff↝,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, Hcy/homoC↓, eff↝, other↝,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
6147- Citrate,    The dual role of citrate in cancer
- Review, Var, NA
Glycolysis↓, Apoptosis↑, eff↝, other↝, eff↝, ChemoSen↑,
4767- CoQ10,    Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review
- Review, Var, NA
chemoP↑, cardioP↑, hepatoP↑, eff↝,
6152- CoQ10,  doxoR,    Phase I Randomized, Placebo-Controlled, Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment
- Trial, BC, NA
eff↝, CardioT↝, ROS↝, ROS↝, ROS↓,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
6681- DCA,    Dichloroacetate (DCA) in Cancer Care
PDK1 / PDPK1↓, Apoptosis↑, ROS↑, lactateProd↓, Dose↝, eff↝, toxicity↓, NP/CIPN↑, Dose↝, *BioAv↑, *Half-Life↓, GSTZ1↝, Glycolysis↓, OXPHOS↑, MPT↑, Cyt‑c↑, AIF↑, Casp↑, CSCs↓, Remission↑, ChemoSen↑, RadioS↑, toxicity↑,
6757- DHA,  EPA,    Does the ratio of eicosapentaenoic acid to docosahexaenoic acid matter in cancer treatment? A systematic review of their effects on cachexia-related inflammation
- Review, Var, NA
eff↝, Inflam↓, CRP↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
2170- dietMet,    Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- Study, Var, NA
OS↑, eff↝, other↝,
5192- dietMet,    Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
OS↑, eff↝, IGF-1↓, adiP↑, Leptin↓, Weight↓,
2165- dietP,  SFN,    Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
- Trial, PC, NA
Dose↝, OS↑, eff↝,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,

Showing Research Papers: 1 to 50 of 122
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 122

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compII↓, 1,   LATS1↓, 1,   NPL4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 2,   CoQ10↑, 1,   Fenton↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GPx1↓, 1,   GPx1↑, 1,   GPx4↓, 3,   GSH↓, 3,   GSH↑, 1,   GSTs↑, 1,   GSTZ1↝, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron↑, 1,   Iron↝, 1,   lipid-P↑, 3,   MPO↓, 1,   NRF2↓, 3,   NRF2↑, 1,   NRF2↝, 2,   OXPHOS↓, 1,   OXPHOS↑, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 40,   ROS↝, 2,   mt-ROS↑, 1,   RPM↑, 1,   SOD↓, 4,   SOD↑, 2,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TrxR↓, 5,   TrxR↑, 1,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 4,   i-ATP↓, 1,   CDC2↓, 1,   EGF↓, 1,   ETC↓, 1,   Insulin↓, 1,   MEK↓, 1,   MMP↓, 17,   MPT↑, 2,   mtDam↑, 1,   PGC-1α↑, 1,   Raf↓, 1,   SDH↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   adiP↑, 1,   AMPK↑, 5,   AMPK↝, 1,   CAIX/CA9↓, 1,   cMyc↓, 2,   ECAR↓, 1,   glut↓, 1,   Glycolysis↓, 8,   HK2↓, 1,   lactateProd↓, 2,   e-lactateProd↓, 1,   LDH↓, 1,   LDH↑, 1,   LDHA↓, 1,   NADPH↓, 1,   NADPH↑, 1,   NH3↓, 1,   PDK1 / PDPK1↓, 2,   PIK3CA↓, 1,   PKM2↓, 2,   p‑S6K↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 24,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 4,   Bcl-2↓, 6,   Casp↑, 6,   Casp12↑, 1,   pro‑Casp12↓, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 7,   Casp9↑, 6,   cl‑Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 11,   Diablo↑, 2,   DR5↑, 3,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GranB/GZMB↑, 1,   GSDMD↑, 1,   IAP1↓, 1,   iNOS↓, 1,   JNK↑, 3,   MAPK↓, 2,   MAPK↑, 3,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 3,   p38↑, 3,   p‑p38↑, 1,   Perforin↑, 1,   PUMA↑, 1,   p‑RSK↑, 1,   survivin↓, 3,   Telomerase↓, 6,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↑, 1,   miR-129-5p↑, 1,   other?, 1,   other↓, 2,   other↑, 2,   other↝, 21,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   HSPs∅, 1,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 1,   mt-UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 3,   p62↓, 3,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 1,   DNAdam↑, 11,   DNMT1↓, 1,   DNMTs↓, 2,   p16↑, 1,   P53↓, 1,   P53↑, 6,   P53↝, 1,   cl‑PARP↑, 4,   PCNA↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 7,   CDK4↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 3,   P21↑, 3,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↓, 1,   CD44↓, 2,   CSCs↓, 10,   Diff↓, 1,   EMT↓, 5,   ERK↓, 4,   ERK↑, 1,   p‑ERK↑, 1,   FOXO3↑, 1,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 4,   HDAC1↓, 2,   HDAC3↓, 1,   IGF-1↓, 4,   IGF-1↑, 1,   IGFBP3↑, 1,   Mst1↑, 1,   mTOR↓, 6,   mTOR↝, 1,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 3,   PI3K↓, 7,   PI3K↑, 1,   PTEN↑, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 6,   p‑STAT3↓, 1,   TOP1↝, 1,   TRPM7↓, 1,   TumCG↓, 12,   TumCG↝, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CA↓, 1,   Ca+2↑, 9,   Ca+2↝, 3,   E-cadherin↓, 1,   E-cadherin↑, 5,   FAK↓, 3,   Ki-67↓, 2,   miR-203↑, 1,   MMP2↓, 9,   MMP9↓, 9,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   Snail↓, 1,   TET1?, 1,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TSP-1↑, 2,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 10,   TumCP∅, 1,   TumMeta↓, 3,   Twist↓, 2,   uPA↓, 4,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 3,   Zeb1↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 5,   EPR↑, 1,   Hif1a↓, 10,   VEGF↓, 15,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   CellMemb↑, 2,   GLUT1↓, 3,   NHE1↓, 1,   P-gp/ABCB1↓, 1,   sonoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   COX2/PTGS2↓, 9,   CRP↓, 1,   CXCR4↓, 2,   IKKα↓, 1,   IKKα↑, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL1β↑, 1,   IL6↓, 4,   IL8↓, 2,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 4,   JAK2↓, 1,   p‑JAK2↓, 1,   pol-M1↝, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 8,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 3,   p50↓, 1,   PD-L1↓, 1,   PDT+↓, 1,   PGE2↓, 4,   PSA↓, 2,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH∅, 1,   e-pH↓, 1,   e-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   AR↝, 1,   CDK6↓, 2,   CDK6↑, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 4,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 18,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 4,   Dose↝, 26,   Dose∅, 2,   eff↓, 5,   eff↑, 56,   eff↝, 133,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,   RadioS↑, 8,   RadioS↝, 1,   selectivity↑, 22,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   AR↓, 1,   AR↝, 1,   BG↓, 2,   CRP↓, 1,   EGFR↓, 5,   Ferritin↓, 3,   Ferritin↑, 1,   GutMicro↑, 2,   Hcy/homoC↓, 4,   Hcy/homoC↝, 1,   HER2/EBBR2↓, 1,   IL6↓, 4,   Ki-67↓, 2,   LDH↓, 1,   LDH↑, 1,   NOS2↑, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 8,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP↑, 2,   CardioT↝, 1,   chemoP↑, 8,   chemoP↝, 1,   chemoPv↑, 3,   ChemoSideEff↓, 2,   fatigue↓, 1,   hepatoP↑, 2,   NDRG1↑, 1,   NP/CIPN↑, 1,   OS?, 1,   OS↑, 11,   OS↝, 1,   QoL↑, 1,   QoL∅, 1,   radioP↑, 3,   radioP↝, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 9,   toxicity↓, 12,   toxicity↑, 4,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 1,   Weight↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 385

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   AntiBio↑, 1,   Eic↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTA1↓, 1,   HO-1↑, 2,   MDA∅, 1,   MPO↑, 1,   NRF2↓, 2,   NRF2↑, 3,   OXPHOS↑, 1,   ROS?, 1,   ROS↓, 6,   ROS↑, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   LDH∅, 1,   NADPH↓, 1,   PKM2↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   Apoptosis∅, 1,   ASK1↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp8↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNArepair↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,  

Migration(tgid=13) ⓘ

CLDN1↑, 1,   MMP2↑, 1,   MMP9↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a↑, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HCAR2↑, 1,   HMGB1↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 10,   PGE2↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   eff↓, 2,   eff↑, 2,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,   LDH∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cachexia↓, 1,   cardioP↑, 3,   chemoP↑, 2,   hepatoP↑, 3,   neuroP↑, 3,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Phen↑, 1,  
Total Targets: 84

Scientific Paper Hit Count for: eff, efficacy
11 Magnetic Fields
9 Silver-NanoParticles
5 Hydrogen Gas
5 Selenium
4 Vitamin B12
4 Folic Acid, Vit B9
4 Phenylbutyrate
4 Thymoquinone
3 Auranofin
3 Radiotherapy/Radiation
3 Magnetic Field Rotating
3 Resveratrol
3 Selenite (Sodium)
3 Shikonin
2 Glucose
2 Apigenin (mainly Parsley)
2 Chemotherapy
2 Artemisinin
2 Baicalein
2 Berberine
2 Caffeic acid
2 Propolis -bee glue
2 Calcium
2 Vitamin D3
2 Coenzyme Q10
2 Dichloroacetate
2 diet FMD Fasting Mimicking Diet
2 diet Methionine-Restricted Diet
2 Sulforaphane (mainly Broccoli)
2 Disulfiram
2 Hyperthermia
2 isoflavones
2 metronomic chemo
2 Vitamin C (Ascorbic Acid)
1 3-bromopyruvate
1 5-Aminolevulinic acid
1 Acetyl-l-carnitine
1 almonertinib
1 Ashwagandha(Withaferin A)
1 Aloe anthraquinones
1 bempedoic acid
1 Betulinic acid
1 Brucea javanica
1 Bacopa monnieri
1 Butyrate
1 Ellagic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 chitosan
1 Citric Acid
1 doxorubicin
1 Curcumin
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 diet Plant based
1 diet Short Term Fasting
1 Dandelion Root
1 Electrical Pulses
1 Exercise
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 Galloflavin
1 Ginger/6-Shogaol/Gingerol
1 Gold NanoParticles
1 Graviola
1 High-Ozonide Oil
1 Juglone
1 Lactoferrin/Talactoferrin
1 Lycopene
1 capecitabine
1 Magnesium
1 Cisplatin
1 Bicarbonate(Sodium)
1 temozolomide
1 Piperlongumine
1 Radio Frequency
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 SonoDynamic Therapy UltraSound
1 Oxygen, Hyperbaric
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Tumor Treating Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:961  State#:%  Dir#:4
wNotes=0 sortOrder:rid,rpid

 

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