DR4 Cancer Research Results

DR4, TNFRSF10A/Death Receptor 4: Click to Expand ⟱
Source:
Type: protein
DR4 (Death Receptor 4, also known as TRAIL receptor 1 or TNFRSF10A).
DR4 is one of the main receptors for TRAIL (TNF-related apoptosis-inducing ligand). • Upon TRAIL binding, DR4 can trigger the extrinsic apoptotic pathway, leading to caspase activation and programmed cell death.

Lower receptor levels often correlate with therapy resistance and aggressive tumor phenotypes, while appropriate or higher levels may enhance susceptibility to apoptosis-based therapies.

TNFRSF10A - Tumor Necrosis Factor Receptor Superfamily Member 10A / Death Receptor 4

Abbreviation: TNFRSF10A, DR4, TRAIL-R1, CD261

Type: Death receptor / TNF receptor superfamily member / extrinsic apoptosis receptor

Function: TNFRSF10A/DR4 is a cell-surface death receptor activated by TRAIL/TNFSF10. Ligand binding promotes formation of the death-inducing signaling complex (DISC), recruitment of adaptor proteins such as FADD, activation of caspase-8 and/or caspase-10, and induction of extrinsic apoptosis.

Cancer: ↓ / impaired DR4 signaling can contribute to resistance to TRAIL-mediated apoptosis. Functional DR4 activation can induce apoptosis in susceptible cancer cells and is therefore generally considered antitumor when the downstream apoptotic machinery remains intact.

Favorable Direction in Cancer: ↑ Functional DR4/TRAIL signaling is generally favorable because it promotes extrinsic apoptosis of cancer cells.

Interpretation Note: DR4/TNFRSF10A should be kept separate from DR5/TNFRSF10B and from the decoy TRAIL receptors TNFRSF10C/D.

TNFRSF21 - Tumor Necrosis Factor Receptor Superfamily Member 21 / Death Receptor 6
Scientific Papers found: Click to Expand⟱
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BID↑, 1,   Casp10∅, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp8∅, 1,   Casp9↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 1,   DR4∅, 2,   DR5↑, 2,   DR5∅, 1,   FADD↑, 2,   FADD∅, 1,   FasL↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4∅, 1,   cycD1/CCND1∅, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

miR-130a↓, 1,   MMPs↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DR4, TNFRSF10A/Death Receptor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:806  State#:%  Dir#:6
  wNotes=0  sortOrder:rid,rpid

 

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