PSD95 Cancer Research Results

PSD95, Postsynaptic density protein 95: Click to Expand ⟱
Source:
Type:
PSD95 (Postsynaptic density protein 95) is a critical scaffolding protein in excitatory synapses, particularly abundant in the postsynaptic density (PSD) of neurons. It plays a key role in synaptic signaling and plasticity, including anchoring NMDA receptors and organizing signaling complexes.
-↓ PSD95 levels in hippocampus and cortex in AD patients and models.
-Loss of PSD95 impairs synaptic plasticity (e.g., LTP) and memory formation
-Hyperphosphorylated tau disrupts PSD95-mediated signaling.
-Agents that preserve or restore PSD95 levels show cognitive benefits in models
Scientific Papers found: Click to Expand⟱
8494- MAG,    Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *PSD95?, *SYN1↑, *SYT1↑, *IL10↑, *TNF-α↓, *IL6↓, *Aβ42↓, *GFAP↓, *other↑, *cognitive↑, *NeuroI↓, *Aβ↓, *GSK‐3β↓, *NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Aβ42↓, 1,   GFAP↓, 1,   NeuroI↓, 1,   SYN1↑, 1,   SYT1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PSD95?, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,  
Total Targets: 15

Scientific Paper Hit Count for: PSD95, Postsynaptic density protein 95
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1359  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

Home Page