IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
9138- CC,    Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties
- Study, Nor, NA
*Ingr↝, *Dose?, *8-oxo-dG↓, *ROS↓, *Inflam↓, *CRP↓, *IL6?, *IL8?, *eff↑, *antiOx↑,
8580- FS,    Anti-Cancer Properties of Flaxseed Proteome
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↑, *Inflam?, *ROS?, *TNF-α?, *IL6?, TumCCA↑, Imm↑, ChemoSen↑, Synergy↑,
7455- HNK,    Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies
- Review, Var, NA
ChemoSen↑, Imm↝, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiCan↑, *Inflam↓, *antiOx↑, Synergy↑, *TNF-α↓, *IL1?, *IL6?,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Imm↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Synergy↑, 2,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   MDA↓, 1,   ROS?, 1,   ROS↓, 1,   SOD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↑, 1,   MAPK↑, 1,   PI3K↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1?, 1,   IL1β↓, 1,   IL6?, 4,   IL8?, 1,   Inflam?, 1,   Inflam↓, 2,   TNF-α?, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   TrkB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6?, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 30

Scientific Paper Hit Count for: IL6, Interleukin-6
1 Baicalin
1 Camu camu
1 Flaxseed/Linseed
1 Honokiol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:158  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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