PKCδ Cancer Research Results

PKCδ, Protein Kinase C delta: Click to Expand ⟱
Source:
Type:
PKCδ is one of the novel isoforms of the Protein Kinase C (PKC) family, involved in regulating various cellular processes.
It participates in diverse signaling pathways influencing cell proliferation, differentiation, survival, apoptosis, and migration.

In some cancers, PKCδ is upregulated and associated with higher tumor aggressiveness, particularly when it contributes to pathways that promote cell survival and invasion.
Conversely, in other contexts, PKCδ has been reported to act as a tumor suppressor where its activation can promote apoptosis or inhibit cell proliferation.
Scientific Papers found: Click to Expand⟱
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,   p‑GSK‐3β↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   cl‑IAP2/BIRC3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CK2↓, 2,   EGFR↓, 1,   ERK↓, 1,   HER2/EBBR2↓, 1,   p‑JNK↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSPs↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   cl‑PARP↑, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   P21↑, 1,   p‑pRB↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   IGFBP3↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   cal2↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   ITGB4↓, 1,   MMPs↓, 2,   TIMP2↑, 1,   TumCI↓, 1,   TumMeta↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   MDR1↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 56

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FABP4↓, 1,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 3,   AMPKα↑, 1,   ERK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   mTOR↑, 1,   PKA↑, 1,   PKCδ↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↑, 1,   other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

Telomerase↓, 1,   TOP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   Diff↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AP-1↓, 1,   Ca+2↓, 1,   TGF-β1↓, 1,   uPA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

memfluid↑, 1,   VGCC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL10↑, 2,   IL1β↓, 2,   IL4↑, 1,   IL6↓, 3,   Imm↝, 1,   Inflam↓, 5,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   NLRP3↓, 1,   TLR4↑, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   CRP↓, 1,   IL6↓, 3,   TMAO↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 3,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Diar↓, 1,   GutMicro↑, 1,  
Total Targets: 85

Scientific Paper Hit Count for: PKCδ, Protein Kinase C delta
1 Apigenin (mainly Parsley)
1 Diindolylmethane
1 Indole-3-carbinol
1 Magnetic Fields
1 Quercetin
1 Taurine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1021  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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