NPC1L1 Cancer Research Results

NPC1L1, Niemann–Pick C1-Like 1: Click to Expand ⟱
Source:
Type:
NPC1L1 (Niemann–Pick C1-Like 1) is best known as a key mediator of intestinal cholesterol absorption and a target for cholesterol-lowering drugs (e.g., ezetimibe). Increasing evidence suggests that NPC1L1 may also play a role in cancer biology.

Overall, NPC1L1 is emerging as a potential biomarker of altered lipid metabolism in cancer, and future studies may help clarify its utility as a prognostic indicator or therapeutic target.
Scientific Papers found: Click to Expand⟱
7982- itraC,    Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- in-vitro, Nor, HUVECs - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
angioG↓, mTOR↓, NPC1L1↓, AMPK↑, VDAC1↓,
1229- OA,    Review of the Clinical Effect of Orlistat
- Review, NA, NA
NPC1L1↓, FASN↓, ER Stress↑, angioG↓, TumCG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   FASN↓, 1,   NPC1L1↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NPC1L1, Niemann–Pick C1-Like 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1050  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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