BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
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Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
6207- CUR,    Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment
- Review, Var, NA - Review, AD, NA
*AntiCan↑, *Obesity↓, *Inflam↓, *lipid-P↓, *BioAv↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *mt-SOD↑, *MDA↓, *BBB↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroG↑, *memory↑, cardioP↑,
7070- GABA,    Neurotransmitters as food supplements: the effects of GABA on brain and behavior
- Review, Nor, NA
*BBB↝, *BBB↓, *fatigue↓, *other↝,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *Synergy↑,
6869- HCAs,  FA,  CA,  RosA,    Exploring the potential of cinnamic acid analogues in alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↓, *Inflam↓, *tau↓, *BioAv↓, *BBB↓, *BioAv↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
9087- MGF,    Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
- Review, Var, NA
TumCP↓, TumCI↓, angioG↓, *BioAv↓, *neuroP↑, *Inflam↓, *AntiCan↑, *ROS↓, *BioAv↑, *BioAv↝, *Half-Life↝, *BBB↓, CDK1↑, CycB/CCNB1↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, PI3K↓, Akt↓, mTOR↓, MMP↓, MOMP↑, Apoptosis↑, lipid-P↑, TCA↓, NRF2↑, NQO1↑, ROS↓, RadioS↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↑, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MOMP↑, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   mTOR↓, 2,   PI3K↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CycB/CCNB1↑, 2,   cycD1/CCND1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TIMP1↓, 1,   TRIB3↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   Obesity↓, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 2,   antiOx↑, 2,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSR↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 2,   mt-lipid-P↓, 1,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 6,   SOD↑, 2,   mt-SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATP↑, 1,   GSK‐3β↓, 2,   NADH:NAD↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   cl‑Casp3↓, 1,   Cyt‑c∅, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXO↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GH↑, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   MMP9↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 10,   BBB↝, 1,   MMP↑, 1,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 8,   NF-kB↓, 1,   NLRP3↓, 1,   p65↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   tau↓, 2,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 11,   BioAv↝, 3,   eff↑, 3,   Half-Life↓, 1,   Half-Life↝, 3,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   fatigue↓, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 7,   Obesity↓, 1,   Risk↓, 1,   Sleep↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   GutMicro↑, 2,  
Total Targets: 76

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
2 Gamma-aminobutyric acid
1 Capsaicin
1 Carvacrol
1 Curcumin
1 Hydroxycinnamic-acid
1 Ferulic acid
1 Caffeic acid
1 Rosmarinic acid
1 Isoliquiritigenin
1 Mangiferin
1 Resveratrol
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1123  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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