CIP2A Cancer Research Results

CIP2A, Cancerous Inhibitor of Protein Phosphatase 2A: Click to Expand ⟱
Source:
Type:
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is an oncoprotein that plays a critical role in promoting tumorigenesis by inhibiting the activity of protein phosphatase 2A (PP2A), a tumor suppressor.

-CIP2A inhibits PP2A, leading to sustained activation of oncogenic signaling pathways such as AKT, MYC, and others that drive cell proliferation, survival, and growth.
-By stabilizing these oncoproteins, CIP2A contributes to tumor initiation, progression, and resistance to apoptosis.


-CIP2A is frequently overexpressed in various cancers, including breast, lung, colorectal, and head and neck cancers, among others.
-Elevated CIP2A expression promotes the malignant phenotype by deregulating key pathways that control cell cycle progression and survival.


-High CIP2A levels are generally associated with a poor prognosis. Increased expression often correlates with more aggressive tumor behavior, higher rates of metastasis, and reduced overall survival.
-In many cancer types, CIP2A overexpression is considered an independent prognostic marker, indicating a greater likelihood of treatment resistance and disease recurrence.
Scientific Papers found: Click to Expand⟱
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTs↑, 1,   HO-1↓, 1,   MAD↓, 1,   ROS↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   OCR↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDH↓, 1,   PDH↝, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   Cyt‑c↑, 1,   DR4↑, 1,   DR5↑, 1,   MAPK↓, 2,   survivin↓, 2,   YAP/TEAD↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↑, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CIP2A↓, 3,   EMT↓, 1,   NOTCH↓, 3,   PI3K↓, 2,   STAT3↑, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   FAK↑, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 2,   PKCδ↓, 1,   Snail↓, 1,   TGF-β↑, 1,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 2,   PD-1↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   Half-Life↝, 1,   selectivity∅, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 1,   toxicity↝, 1,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ARE↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,   SOD1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

neuroG↑, 1,   STAT↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   toxicity↝, 1,  
Total Targets: 19

Scientific Paper Hit Count for: CIP2A, Cancerous Inhibitor of Protein Phosphatase 2A
1 Cucurbitacin
1 Ellagic acid
1 Lycopene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1154  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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