tyrosinase Cancer Research Results

tyrosinase, tyrosinase: Click to Expand ⟱
Source:
Type:
Tyrosinase expression has been evaluated in various cancers—primarily melanoma—and its association with prognosis.
Tyrosinase and Cancer — Melanocytic Lineage Enzyme, Differentiation Marker, and Selective Target
Melanin Synthesis, Lineage Marker, and Therapeutic Handle

– Tyrosinase is normally expressed in melanocytes and is generally maintained in melanomas.
– Elevated tyrosinase expression in blood (detectable tyrosinase mRNA) has been correlated with advanced disease stage and the presence of micrometastases.
Direction of Regulation in Cancer
-Context-specific, but most informative in melanoma:
-Upregulated in differentiated melanocytic tumors
-Downregulated or lost in dedifferentiated, invasive, therapy-resistant melanoma states

Thus, tyrosinase is best read as a lineage/differentiation marker, not a universal oncogenic driver.


Scientific Papers found: Click to Expand⟱
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   DPPH↓, 1,   GPx↑, 1,   GSR↑, 1,   lipid-P↓, 1,   ROS?, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

tyrosinase↓, 2,  

Migration(tgid=13) ⓘ

EMT↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL17↓, 1,   IL1β↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

monoA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   neuroP↑, 1,   PDE4↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: tyrosinase, tyrosinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1160  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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