Insulin Cancer Research Results

Insulin, Insulin: Click to Expand ⟱
Source:
Type:
Insulin, traditionally known for its role in regulating blood glucose levels, also exerts potent mitogenic (cell division–promoting) effects.

Insulin exerts its effects primarily through binding to the insulin receptor (IR), a receptor tyrosine kinase. Upon binding, the receptor undergoes autophosphorylation and activates several downstream signaling cascades, including:
-PI3K/Akt Pathway: Overactivation of this pathway is often observed in cancers.
-RAS/MAPK Pathway: aberrant activation can lead to tumorigenesis.

IR-A: Often predominates in fetal tissues and some cancer cells. It has a higher affinity for insulin-like growth factors (IGFs) and is more mitogenic.
IR-B: More involved in metabolic regulation.

Studies have shown that many cancers (such as breast, colon, and lung cancers) preferentially overexpress the IR-A isoform.
Scientific Papers found: Click to Expand⟱
6622- Cic,    Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans
- in-vivo, Nor, NA
*ROS↓, *AMPK↑, *GPx↑, *SOD↑, *SOD2↑, *PGC-1α↑, *Akt↓, *mTOR↓, *Insulin↓, *antiOx↑, *AntiAge↑,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
8624- dietKeto,    Impact of ketogenic diets on cancer patient outcomes: a systematic review and meta-analysis
- Review, Var, NA
*Weight↓, *Insulin↓, *glucose↓, *fatigue↓, *Sleep↑, *LDL↓, *TC↓, *BHB↑, *ketosis↑, eff↑, CRP↓, Inflam↓, angioG↓,
2265- dietMet,    Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
- in-vivo, Nor, NA
*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
3708- dietSTF,    Fasting as a Therapy in Neurological Disease
- Review, Nor, NA
*PGC-1α↑, *AMPK↑, *adiP↑, *glucose↓, *Insulin↓, *mTOR↓, *IL6↓, *TNF-α↓, *cognitive↑, *Inflam↓, *eff↑, *neuroP↑, ChemoSen↑, eff↓, chemoP↑, *eff↑,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
8604- FSO,  VitD3,    An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management
- Trial, Diabetic, NA
*TAC↑, *Weight↓, *glucose↓, *Insulin↓, *TG/TAG↓, *TC↓, *QoL↑, *Pain↓, *toxicity↓, *Dose↝,
7638- Ins,    d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI)
- Review, Nor, NA
*Insulin↝, *CYP19↓, *Dose↝, *Dose↝, *other↝, *Insulin↓, *IRes↓, *Obesity↓, *BioAv↝,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
2248- MF,    Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study
- in-vivo, Nor, NA
*PGC-1α↑, *GutMicro↑, *FAO↓, *Insulin↓,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CRM↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   p27/CDKN1B↓, 1,   pRB↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   eff↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   chemoP↑, 1,   Risk↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GPx↑, 1,   GSH↓, 1,   HDL∅, 1,   MDA↓, 1,   ROS↓, 4,   SOD↑, 1,   SOD2↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 12,   Insulin↝, 1,   PGC-1α↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 3,   ALAT↓, 1,   AMPK↑, 4,   BHB↑, 1,   CRM↑, 1,   FAO↓, 1,   glucose↓, 7,   glyC↓, 1,   Glycolysis↝, 1,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   PIP3↑, 1,   PKM2↑, 1,   SCD1↓, 1,   SIRT1↑, 2,   SIRT2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   IGFR↓, 1,   mTOR↓, 3,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   IGF-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

ketosis↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 2,   Inflam↓, 3,   TNF-α↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   FGF21↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   CompStab↝, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 2,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 2,   IRes↓, 1,   TC↓, 3,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 3,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 2,   neuroP↑, 3,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   Sleep↑, 1,   toxicity↓, 1,   toxicity↝, 1,   Weight↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 82

Scientific Paper Hit Count for: Insulin, Insulin
2 Resveratrol
2 diet Methionine-Restricted Diet
1 Cichoric acid / Chicoric acid
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 diet Ketogenic
1 diet Short Term Fasting
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Vitamin D3
1 Inositol
1 Metformin
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1190  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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