Pin1 Cancer Research Results

Pin1, Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1: Click to Expand ⟱
Source:
Type:
Pin1 (Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1) is a peptidyl-prolyl isomerase that specifically recognizes phosphorylated serine/threonine-proline motifs, thereby modulating the conformation and function of various proteins. This post-phosphorylation regulation can directly affect cell division, survival, and metastasis—all of which impact cancer progression.

High Pin1 expression in breast, pca, had and lung cancers is associated with more aggressive tumor behavior, increased metastatic potential, and poorer overall survival.

Inhibitors:
-Juglone (5-hydroxy-1,4-naphthoquinone) is one of the most widely studied natural inhibitors of Pin1.
-All‑trans Retinoic Acid (ATRA).
A metabolite of vitamin A, ATRA has been reported to inhibit Pin1 activity.
-EGCG
-Curcumin (Proposed)

Juglone is thought to act via direct covalent modifications of Pin1, whereas ATRA and EGCG likely interact through non-covalent binding.
Scientific Papers found: Click to Expand⟱
7820- JG,    Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription
Pin1↓,
7962- JG,    Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide
- in-vitro, Var, NA
eff↑, Pin1↓, *DNAdam↓,
8007- JG,    Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis
- in-vitro, GBM, U251
Pin1↓, AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, TumCMig↓, angioG↓, VEGF↓, CD31/PECAM-1↓, TGF-β1↓,
7964- JG,    Juglone and KPT6566 Suppress the Tumorigenic Potential of CD44+CD133+ Tumor-Initiating Caco-2 Cells In Vitro and In Vivo
- vitro+vivo, Colon, Caco-2
CSCs↓, TumVol↓, Pin1↓,
7963- JG,    Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145
Pin1↓, TumCP↓, TumVol↓, other↝,
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,
5113- JG,    Juglone in Oxidative Stress and Cell Signaling
- Review, Var, NA - Review, AD, NA
ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   Catalase↓, 1,   GPx↓, 1,   GSH↓, 2,   lipid-P↑, 1,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 3,   BAX↑, 3,   Bcl-2↓, 2,   Casp3↑, 3,   Casp9↑, 2,   Cyt‑c↑, 1,   Fas↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   EMT↓, 1,   EMT↑, 1,   GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   SMAD2↓, 1,   TGF-β1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   Pin1↓, 8,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 50

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Pin1, Peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1
8 Juglone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page