tau Cancer Research Results

tau, tau: Click to Expand ⟱
Source:
Type:
In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport.

In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure.
-Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma.
-Imaging techniques like tau PET scans can visualize tau deposits in the brain.
Natural Products targeting tau
-Curcumin                via GSK-3β inhibition
-Resveratrol             Activates SIRT1
-EGCG                    inhibits Tau, but BBB penetration is questionable
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3441- ALA,    α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
- in-vivo, AD, NA
*tau↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, *VEGF↑, *HO-1↑, *Glycolysis↑, *HK1↑, *PGC-1α↑, *Hif1a↑, *neuroP↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
3819- Aroma,    Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
- Human, AD, NA - in-vitro, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *tau↓, *BDNF↑, *motorD↑,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
4304- Ba,    Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
- in-vitro, AD, NA
*tau↓, *Dose↝, *BioAv↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1/ATG6↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
- Review, Var, NA
*memory↑, *neuroP↑, *cognitive↑, *hepatoP↑, *antiOx↑, *AntiDiabetic↑, *fatigue↓, *GSK‐3β↓, *PI3K↑, *Akt↑, *tau↓, *ROS↓, *Inflam↓,
7832- CA,  CGA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *cognitive↑, *memory↑, *ROS↓, *p‑tau↓, *GSK‐3β↓, *MAPK↓, *NeuroI↓, *P53↓, *Casp3↓, *AChE↓, *APP↓, *BACE/β-secretase↓, *neuroP↑, *Dose↝,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
5756- CA,    Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights
- vitro+vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AChE↓, *BChE↓, *cognitive↑, *ROS↓, *Aβ↓, *tau↓, eff↑,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *Stroke↓, *Risk↓,
5854- CAP,    Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Review, Var, NA - Review, AD, NA
Obesity↓, Half-Life↓, antiOx↑, TRPV1↑, STAT3↓, Ca+2↑, ROS↑, MMP↓, *neuroP↑, *tau↓, *Inflam↓, *ROS?,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
3855- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Risk↓, *Aβ↓, *p‑tau↓, *Inflam↓, *neuroP↑, *cognitive↑, *ADAM10↑, *PPARα↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
6040- CGA,    Protective effect of chlorogenic acid on cognitive impairment in rats with early Alzheimer's disease via Wnt signaling pathway
- in-vivo, AD, NA
*neuroP↑, *Dose↝, *GSK‐3β↓, *tau↓, *β-catenin/ZEB1↑, *Wnt↑, *memory↑, *cognitive↑, *NRF2↑, *ROS↓,
3888- Cin,    Cinnamon, a promising prospect towards Alzheimer's disease
- Review, AD, NA
*tau↓, *Aβ↓, *neuroP↑, *ROS↓, *Inflam↓, *cardioP↑, *antiOx↑, *cognitive↑, *BBB↑, *p‑GSK‐3β↑, *AChE↓,
3889- Cin,    Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *tau↓,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2/PTGS2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
3893- Cin,    Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro
- Review, AD, NA
*tau↓, *toxicity↓,
3894- Cin,    Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis
- in-vitro, AD, NA
*tau↓, *ROS↓,
6169- Cin,    Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, IBD, NA
*neuroP↑, *AntiDiabetic↑, *tau↓, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *MDA↓, *GSH↓, *cardioP↑, *LDL↓, *HDL↑, *other↝, *TNF-α↓, *IL6↓, *MPO↓, *TLR4↓, *GutMicro↑, *lipid-P↓, *Wound Healing↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
6181- Cro,    Crocetin: A Systematic Review
- Review, Var, NA - Review, AD, NA
cardioP↑, hepatoP↑, *neuroP↑, AntiCan↑, *AntiDiabetic↑, *memory↑, *BioAv↓, *ROS↓, Apoptosis↑, *lipid-P↓, *SOD↑, SOD↓, ERα/ESR1↓, HDAC2↓, TumCCA↑, Bax:Bcl2↑, IL6↓, IL8↓, Shh↓, COX2/PTGS2↑, *GSK‐3β↓, *ERK↓, *tau↓, *ROS↓, *GSTs↑, *Catalase↑, *SOD↑, *BioAv↑,
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
6050- CUR,  SeNPs,    Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *AChE↓, *Aβ↓, *P53↓, *tau↓, *NRF2↓, *TNF-α↓, *NO↑, *Catalase↑, *antiOx↑, *Inflam↓,
3793- CUR,    Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *memory↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *Synergy↑,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
6207- CUR,    Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment
- Review, Var, NA - Review, AD, NA
*AntiCan↑, *Obesity↓, *Inflam↓, *lipid-P↓, *BioAv↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *mt-SOD↑, *MDA↓, *BBB↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroG↑, *memory↑, cardioP↑,
6208- CUR,    Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
- Trial, Nor, NA
*memory↑, *Aβ↓, *tau↓,
3592- EGCG,    (-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer's disease
- in-vivo, AD, NA
*neuroP↑, *memory↑, *p‑tau↓,
3591- EGCG,    Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats
- in-vivo, AD, NA
*p‑tau↓, *BACE/β-secretase↓, *Aβ↓, *Ach↑, *AChE↓, *antiOx↑, *memory↑, *hepatoP↑, *ROS↓, *GPx↑, *SOD↑,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
4291- EGCG,    Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
- in-vitro, AD, NA
*tau↓, *BBB∅,
4290- EGCG,    EGCG impedes human Tau aggregation and interacts with Tau
- in-vitro, AD, NA
*tau↓, *Dose↝, *neuroP↑, *antiOx↑,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE/β-secretase↓, *LC3II↓, *Beclin-1/ATG6↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,

Showing Research Papers: 1 to 50 of 174
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 174

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Iron↝, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   ROS↓, 3,   ROS↑, 6,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   GSK‐3β↑, 1,   SIRT1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   BAX↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   cl‑Casp3⇅, 1,   Casp9↑, 4,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Necroptosis↑, 1,   p38↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 2,   ERK↓, 2,   HER2/EBBR2↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↝, 1,   PI3K↓, 1,   PKCδ↓, 2,   RAS↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC2↓, 1,   miR-25-5p↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↓, 1,   P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Shh↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   BACH1↓, 1,   Ca+2↑, 1,   EMT↓, 2,   KRAS↓, 1,   LAMs↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Smad1↓, 1,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 2,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 1,   NF-kB↓, 3,   PD-1↓, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 5,   Dose↝, 1,   eff↑, 2,   Half-Life↓, 1,   P-gp/ABCB1↓, 2,   selectivity↑, 2,   Synergy↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   KRAS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   cardioP↑, 2,   hepatoP↑, 1,   NP/CIPN↓, 1,   Obesity↓, 1,  
Total Targets: 116

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 4,   antiOx↑, 57,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 17,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 15,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 25,   GSR↓, 1,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 19,   HO-2↓, 1,   hyperG↓, 1,   Iron↝, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 19,   MDA↑, 2,   MPO↓, 3,   NOX↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↓, 2,   NRF2↑, 31,   RNS↓, 2,   ROS?, 1,   ROS↓, 93,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↓, 1,   SOD↑, 30,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↑, 7,   TBARS↓, 2,   Thiols↑, 1,   Trx1↑, 1,   TrxR↑, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 3,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   compV↑, 1,   ETC↑, 1,   FIS1↓, 1,   Insulin↑, 1,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 2,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 1,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 1,   ALAT↓, 2,   AMPK↑, 10,   ATP↑, 10,   cAMP↑, 2,   FAO↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 33,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 2,   ac‑Histones↑, 1,   HK1↑, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↓, 1,   SIRT1↑, 6,   SIRT1∅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 12,   BAX↓, 5,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 7,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 9,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp9↑, 1,   Ferroptosis↓, 3,   iNOS↓, 10,   necrosis↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 15,   p‑Akt↓, 2,   p‑Akt↑, 3,   CaMKII ↓, 2,   CREB↓, 1,   CREB↑, 5,   p‑CREB↑, 4,   DYRK1A↓, 2,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 6,   mTOR↑, 2,   p‑mTOR↓, 1,   PI3K↓, 4,   PI3K↑, 12,   PKA↑, 3,   PKCδ↑, 2,   PP2A↑, 8,   PTEN↓, 2,   PTP1B↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   DNMT1↓, 1,   HDAC?, 1,   HDAC↓, 1,   HDAC2↓, 1,   MEF2D↑, 1,   other↓, 1,   other↑, 6,   other↝, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 3,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 3,   HSP90↓, 1,   HSPs↝, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   CTSZ↓, 1,   CTSZ↝, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 2,   lysosome↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 2,   PARP1↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 6,   cellSen↝, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   mTORC1↓, 1,   neuroG↑, 2,   Wnt↑, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 10,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   LRP1↑, 1,   MMP-10↝, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↑, 1,   ROCK1↓, 1,   TXNIP↓, 3,   β-catenin/ZEB1↑, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   CD31/PECAM-1↑, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 2,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 30,   BBB↝, 1,   BBB∅, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   GLUT3↑, 2,   GLUT4↑, 2,   MMP↑, 8,   THBD↑, 1,   TRPA1↑, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 11,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 1,   IL2↓, 2,   IL22↓, 1,   IL23↓, 1,   IL33↓, 1,   IL4↓, 1,   IL4↑, 3,   IL6↓, 26,   IL8↓, 2,   Imm↑, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 83,   Inflam↑, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 6,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 9,   NF-kB↓, 29,   p‑NF-kB↓, 3,   NLRP3↓, 10,   p‑p65↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 4,   TNF-α↓, 37,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 5,   Ach↑, 13,   AChE↓, 37,   ADAM10↑, 4,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 20,   BrainVol↑, 1,   CARTPT↑, 1,   ChAT↑, 6,   CHRM1↑, 1,   GABA↑, 1,   MAOA↓, 3,   MAOB↓, 4,   NGF↑, 2,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   SYP↑, 1,   TrkB↓, 1,   TrkB↑, 2,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 14,   APP↝, 1,   Aβ↓, 98,   Aβ42↓, 5,   BACE/β-secretase↓, 29,   IDE↑, 1,   PSEN1/PS1↓, 2,   tau↓, 69,   p‑tau↓, 106,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   PPARα↑, 4,   PPARγ↓, 2,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 14,   BioAv↑, 24,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 25,   eff↓, 1,   eff↑, 11,   Half-Life↑, 1,   Half-Life↝, 1,   P450↑, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALB↑, 1,   anemia↓, 1,   AST↓, 2,   BloodF↑, 2,   BP↓, 1,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   Hcy/homoC↓, 1,   HemoG↑, 2,   IL6↓, 26,   IRes↓, 1,   NOS2↓, 1,   RBC↑, 1,   TC↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 4,   AntiMyl↑, 1,   antiPs↑, 1,   ANXi↓, 1,   cardioP↑, 10,   chemoP↑, 1,   cognitive↑, 91,   cognitive↝, 1,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 7,   Learn?, 1,   Learn↑, 7,   memory?, 1,   memory↑, 83,   Mood↑, 3,   motorD↓, 1,   motorD↑, 7,   neuroP↑, 109,   Obesity↓, 4,   OS↑, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 7,   Sleep↑, 4,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 5,   toxicity↓, 9,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 4,   Bacteria↓, 4,   GutMicro↑, 13,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 389

Scientific Paper Hit Count for: tau, tau
9 Curcumin
9 Resveratrol
9 Urolithin
7 Mung Bean Sprouts
7 EGCG (Epigallocatechin Gallate)
6 Cinnamon
6 Emodin
5 Selenium NanoParticles
5 Shilajit/Fulvic Acid
5 Ginseng
5 Luteolin
5 Methylene blue
5 Quercetin
4 Berberine
4 Caffeic acid
4 Capsaicin
4 Hydrogen Gas
4 isoorientin
4 Vitamin B1/Thiamine
3 Bacopa monnieri
3 Folic Acid, Vit B9
3 Ferulic acid
3 Sulforaphane (mainly Broccoli)
3 Vitexin
3 Isovitexin
3 Mangiferin
3 Moringa oleifera
3 Morin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Chlorogenic acid
2 Crocetin
2 Rosmarinic acid
2 Lactoferrin/Talactoferrin
2 Lycopene
2 Magnolol
2 Magnetic Fields
2 Melatonin
2 Vitamin B3,Niacin
2 Vitamin K2
1 1,8-Cineole
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aromatherapy
1 Beta-Caryophyllene
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Calorie Restriction Mimetics
1 Phosphatidylserine
1 Fisetin
1 Flickering Light Stimulation
1 Formononetin
1 Ginkgo biloba
1 hydrogen sulfide
1 Hydroxycinnamic-acid
1 Honokiol
1 Hyperoside
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Potassium
1 Kaempferol
1 Licochalcone A
1 Vitamin E
1 Magnesium
1 Silver-NanoParticles
1 Zeolite
1 Methylsulfonylmethane
1 L-Theanine
1 nicotinamide adenine dinucleotide
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Pterostilbene
1 chitosan
1 Rutin
1 S-adenosyl-L-methionine
1 Carvacrol
1 Shankhpushpi
1 Silymarin (Milk Thistle) silibinin
1 Ursolic acid
1 Vitamin B12
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1231  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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