Securin Cancer Research Results
Securin, PTTG1: Click to Expand ⟱
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Securin is a protein encoded by the PTTG1 (pituitary tumor-transforming gene 1) gene and plays a crucial role in cell cycle regulation, notably in sister chromatid separation.
-Elevated levels of securin have been reported in a wide range of cancers.
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Scientific Papers found: Click to Expand⟱
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vitro+vivo, |
Ovarian, |
NA |
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CSCs↓, Securin↓, ALDH1A1↓,
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
Showing Research Papers: 1 to 4 of 4
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↓, 1, ROS↑, 2,
Mitochondria & Bioenergetics(tgid=3) ⓘ
CDC2↓, 1, CDC25↓, 1, MEK↓, 1, MMP↓, 1, XIAP↓, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
12LOX↓, 1, ACC↑, 1, AMPK↑, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 2, p‑Akt↓, 1, Apoptosis↑, 1, BAD↑, 1, BAX↑, 1, Bcl-2↓, 1, BIM↑, 1, Casp3↑, 2, cl‑Casp8↑, 1, Casp9↑, 1, Cyt‑c↑, 1, Diablo↑, 1, DR5↑, 2, Fas↑, 1, MAPK↓, 1, Mcl-1↓, 1, TRAIL↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
cJun↓, 1, tumCV↓, 1,
Protein Folding & ER Stress(tgid=8) ⓘ
CHOP↑, 1, HSP70/HSPA5↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↑, 1, cl‑PARP↑, 1, γH2AX↝, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 2, Securin↓, 4, TumCCA↓, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
ALDH1A1↓, 1, cFos↓, 1, CSCs↓, 1, p‑ERK↓, 1, mTOR↓, 3, PI3K↓, 1, PTEN↑, 1, TCF↓, 1, TCF↑, 1, TumCG↓, 1, TumCG↑, 1, Wnt↓, 2,
Migration(tgid=13) ⓘ
E-cadherin↓, 1, Fibronectin↓, 1, MMP1↓, 1, MMP2↓, 2, MMP7↓, 1, MMP9↓, 1, N-cadherin↓, 2, Snail↓, 1, TumCI↓, 1, TumCMig↓, 1, TumMeta↓, 1, uPA↓, 2, Vim↓, 2, Zeb1↓, 1, ZEB2↓, 1, β-catenin/ZEB1↓, 2,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1, EGFR↓, 2,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2↓, 2, NF-kB↓, 2, NF-kB↑, 1, PGE2↓, 2, PSA↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, ChemoSen↑, 2, eff↑, 1, RadioS↑, 2,
Clinical Biomarkers(tgid=22) ⓘ
EGFR↓, 2, PSA↓, 1,
Functional Outcomes(tgid=23) ⓘ
AntiTum↑, 1,
Total Targets: 82
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, GSH↑, 2, HO-1↑, 1, NRF2↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
p‑CREB↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
ERK↑, 1,
Migration(tgid=13) ⓘ
5LO↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Inflam↓, 1,
Functional Outcomes(tgid=23) ⓘ
chemoPv↑, 1, memory↑, 1, neuroP↑, 1,
Total Targets: 11
Scientific Paper Hit Count for: Securin, PTTG1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:1334 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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