ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱
Source:
Type:
antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance
Scientific Papers found: Click to Expand⟱
8866- MOR,    Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway
- in-vitro, Nor, NA
*HO-1↑, *NRF2↑, *ARE↓, *ERK↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1354  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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