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| Glutathione (GSH) is a thiol antioxidant that scavenges reactive oxygen species (ROS), resulting in the formation of oxidized glutathione (GSSG). Decreased amounts of GSH and a decreased GSH/GSSG ratio in tissues are biomarkers of oxidative stress. Glutathione is a powerful antioxidant found in every cell of the body, composed of three amino acids: cysteine, glutamine, and glycine. It plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting the immune system. cancer cells can have elevated levels of glutathione, which may help them survive in the oxidative environment created by the immune response and chemotherapy. This can make cancer cells more resistant to treatment. While glutathione can be obtained from certain foods (like fruits, vegetables, and meats), its absorption from supplements is debated. Some people take N-acetylcysteine (NAC) or other precursors to boost glutathione levels, but the effects on cancer prevention or treatment are still being studied. Depleting glutathione (GSH) to raise reactive oxygen species (ROS) is a strategy that has been explored in cancer research and therapy. Many cancer cells have altered redox states and may rely on GSH to survive. Increasing ROS levels can induce stress in these cells, potentially leading to cell death. Certain drugs and compounds can deplete GSH levels. For example, agents like buthionine sulfoximine (BSO) inhibit the synthesis of GSH, leading to its depletion. Cancer cells tend to exhibit higher levels of intracellular GSH, possibly as an adaptive response to a higher metabolism and thus higher steady-state levels of reactive oxygen species (ROS). "...intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS)..." "Cancer cells have a high level of GSH compared to normal cells." "...cancer cells are affluent with high antioxidant levels, especially with GSH, whose appearance at an elevated concentration of ∼10 mM (10 times less in normal cells) detoxifies the cancer cells." "Therefore, GSH depletion can be assumed to be the key strategy to amplify the oxidative stress in cancer cells, enhancing the destruction of cancer cells by fruitful cancer therapy." The loss of GSH is broadly known to be directly related to the apoptosis progression. |
| 4382- | AgNPs, | Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism |
| - | in-vitro, | Nor, | RAW264.7 |
| 2287- | AgNPs, | Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine |
| - | in-vitro, | Nor, | HUVECs |
| 236- | AL, | Allicin: Chemistry and Biological Properties |
| - | Analysis, | Nor, | NA |
| 3395- | ART/DHA, | Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis |
| - | in-vitro, | Nor, | HSC-T6 |
| 3163- | Ash, | Rad, | Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis |
| - | in-vitro, | Var, | NA |
| 5506- | Ba, | Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System |
| - | in-vivo, | Nor, | NA |
| 6169- | Cin, | Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management |
| - | Review, | Var, | NA | - | Review, | Diabetic, | NA | - | Review, | AD, | NA | - | Review, | IBD, | NA |
| 2269- | dietMet, | Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice |
| - | in-vivo, | Nor, | NA |
| 1896- | dietMet, | Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies |
| - | in-vivo, | CRC, | NA |
| 6771- | GI, | A glimpse on influences of ginger and its derivatives as a feed additive in finfish farming: A mini-review |
| - | Review, | Nor, | NA |
| 5050- | HPT, | Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review |
| - | Review, | Nor, | NA |
| 7803- | IBC, | Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response |
| - | in-vivo, | Nor, | NA | - | in-vitro, | NA, | HepG2 |
| 8153- | JG, | Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes |
| - | in-vitro, | Nor, | HaCaT |
| 8167- | LapC, | Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae |
| - | in-vitro, | Nor, | NA |
| 8549- | Matr, | Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis |
| - | in-vitro, | Var, | NA |
| 1767- | PG, | Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione |
| - | in-vitro, | Nor, | NA |
| 2004- | PLB, | Plumbagin Inhibits Proliferative and Inflammatory Responses of T Cells Independent of ROS Generation But by Modulating Intracellular Thiols |
| - | in-vivo, | Var, | NA |
| 3311- | SIL, | Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells |
| - | in-vitro, | Nor, | PC12 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:137 State#:% Dir#:1
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