Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
5296- 5-HTP,    Serotonergic Regulation in Alzheimer’s Disease
- Review, AD, NA
*Risk↓, *5HT↓, *ROS↓, *MDA↓, *Apoptosis↓, *Mood↑, *other↑, *other↑,
7842- AAL,  ISQ,  RT,    Annona atemoya leaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer's disease-like mouse model
- in-vivo, AD, HT22
*Aβ↓, *ROS↓, *Apoptosis↓, *memory↑, *BDNF↓, *Dose↝, *neuroP↑,
2656- AL,    Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
- in-vitro, Park, PC12
*antiOx↑, *Apoptosis↓, *LDH↓, ROS↓, *lipid-P↓, *mtDam↓, *MMP↓, *Cyt‑c↓, *ATP∅, *Ca+2↝, *neuroP↑,
3433- ALA,    Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
- in-vitro, Nor, NA
*ROS↓, *Apoptosis↓, *Hif1a↑, *FOXO1↑, *FOXO3↑, *ATM↑, *SIRT1↑, *SIRT3↑, *CD34↑,
3551- ALA,    Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *Inflam↓, *antiOx↑, *BioAv↝, *neuroP↑,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
3886- Api,    Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
- in-vitro, AD, NA
*Inflam↓, *neuroP↑, *NO↓, *Apoptosis↓,
3672- Ash,    Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
- Review, Nor, NA
*cardioP↑, *antiOx↑, *ROS↓, *neuroP↑, *Inflam↓, *Apoptosis↓,
3670- Ash,    Neurodegenerative diseases and Withania somnifera (L.): An update
- Review, AD, NA - Review, Park, NA
*Apoptosis↓, *Inflam↓, *ROS↓, *neuroP↑,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
4813- ASTX,    Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function
- in-vitro, AD, NA
*antiOx↑, *Apoptosis↓, *AntiTum↑, *ROS↓, *MMP↑, *neuroP↑,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
2724- BetA,    Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
- in-vivo, Nor, NA - in-vivo, Stroke, NA
AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE/β-secretase↓, *cognitive↑, *BioAv↑, memory↑, P-gp/ABCB1↓, BioEnh↑,
3507- Bor,    Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling
- in-vivo, Nor, NA
*MMP↑, *Cyt‑c↓, *Apoptosis↓, *Casp3↓, *NO↓, *iNOS↓,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6560- BSB,  doxoR,    Α-Bisabolol, a Component of German Chamomile Tea Attenuates NLRP3 Inflammasome Mediated Pyroptosis, NF-ΚB/MAPK Signaling Activation and Apoptosis by Invoking NRF2 Mediated Antioxidant Defense Systems in Doxorubicin-Induced Liver Injury in Rats
- in-vivo, Nor, NA
*lipid-P↓, *antiOx↑, *Apoptosis↓, *Inflam↓,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
7520- CAPE,    Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,
5902- CAR,    A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol
- in-vitro, Nor, HEK293
*other↓, *GSH↑, *GPx↑, *ROS↓, *Apoptosis↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
6119- Chol,    Is Citicoline Effective in Preventing and Slowing Down Dementia?—A Systematic Review and a Meta-Analysis
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, *Ach↑, *Apoptosis↓, *neuroP↑, *memory↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
6624- Cic,    Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *TNF-α↓, *IL1β↓, *MDA↓, *Catalase↑, *GSH↑, *NRF2↑, *mtDam↓, *Inflam↓, *Apoptosis↓, *ROS↓, *cognitive↑, *Aβ↓, *BDNF∅, *APP↓, *BACE/β-secretase↓,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
8993- Citicoline,    Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells
- in-vitro, Nor, PC12
*Apoptosis↓, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GSH↑, *BAX↓, *Bcl-2↑, *Casp3↓, *neuroP↑, *ROS↓,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
3832- Cro,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *memory↑, *Apoptosis↓, *cognitive↑, *ER Stress↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
5070- dietSTF,    A review of fasting effects on the response of cancer to chemotherapy
- Review, Var, NA
chemoP↑, ChemoSen↑, *DNArepair↑, *Apoptosis↓, *CD8+↑, UPR↑, eff↝, TumAuto↑,
8850- DIM,    3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity
- vitro+vivo, BC, MDA-MB-231
RadioS↑, radioP↑, eff↝, Imm↑, *ROS↓, *Apoptosis↓,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6349- DRE,    Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
- vitro+vivo, Nor, NCM460
*Apoptosis↓, *ROS↓, *NF-kB↓, *other↓,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *ALB↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
7208- EGb 761,    EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
- in-vitro, Nor, SH-SY5Y
*Ca+2↑, *Apoptosis↓, *ROS↓, *MMP↑, *Casp3↓, *Casp9↓,
7219- EGb 761,    Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells
- in-vitro, Nor, SK-N-BE
*MMP↑, *Bax:Bcl2↓, *cl‑PARP↓, *i-antiOx↑, *mt-Apoptosis↓, *neuroP↑,
3206- EGCG,    Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration
- Review, AMD, NA
*Ca+2↓, *ROS↓, *Apoptosis↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *PERK↓, *IRE1↓, *p‑PARP↓, *Casp3↓, *Casp12↓, *ER Stress↓, *UPR↓,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
6410- EGCG,    Evaluation of the neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage
- in-vitro, Nor, NA
*FIS1↓, *neuroP↑, *Ca+2↓, *VGCC↝, *ROS↓, *DNAdam↓, *Apoptosis↓,

Showing Research Papers: 1 to 50 of 167
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 167

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx4↓, 1,   GSH↓, 2,   HO-1↑, 1,   Iron↑, 1,   Iron↝, 1,   lipid-P↑, 1,   MDA↑, 2,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 9,   mt-ROS↑, 1,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 2,   glucose↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 2,   Bak↓, 1,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-2↑, 1,   BID↑, 1,   BNIP3↑, 1,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 1,   Fas↑, 1,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   Perforin↝, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 2,   JAK2↓, 1,   MAPK↓, 1,   mTOR↓, 2,   PI3K↓, 3,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cMyc↓, 1,   miR-34a↓, 1,   miR-375↝, 1,   other↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 2,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   CSCs↓, 1,   FGF↓, 1,   Ki-67↓, 2,   NOTCH1↓, 1,   TumCG↓, 4,   TumCP↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   EMT↓, 1,   Slug↓, 1,   TET1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TumMeta↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↑, 1,   Imm↑, 3,   Inflam↓, 1,   NF-kB↓, 2,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↑, 1,   PD-L1↓, 1,   TLR4↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 6,   Dose↝, 2,   eff↑, 3,   eff↝, 4,   P-gp/ABCB1↓, 2,   RadioS↑, 2,   selectivity↑, 3,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 2,   PD-L1↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 5,   fatigue↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   OS↑, 1,   OS↝, 1,   Pain↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 1,   TumVol↓, 2,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 144

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 1,   antiOx↑, 53,   i-antiOx↑, 1,   ARE↑, 3,   Bil↓, 1,   Catalase↑, 24,   Copper↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLC↝, 1,   GCLM↑, 1,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 17,   GPx4↑, 2,   GSH↑, 29,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 2,   H2O2↓, 2,   HO-1↑, 30,   HO-1⇅, 1,   Iron↓, 3,   Iron↝, 1,   i-Iron↓, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 22,   MDA↓, 29,   MDA↑, 1,   MPO↓, 5,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 4,   NQO1↝, 1,   Nrf1↑, 1,   NRF2↑, 48,   RNS↓, 1,   ROS↓, 109,   ROS∅, 1,   SOD↓, 1,   SOD↑, 39,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 2,   TAC↑, 6,   TBARS↓, 5,   Trx↓, 1,   Trx1↑, 1,   UCPs↑, 1,   uricA↓, 2,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 12,   NGB↑, 1,   PGC-1α↑, 5,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 2,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 2,   ALAT↓, 8,   ALDOA↑, 1,   ALDOC↑, 1,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 5,   ATP∅, 1,   cAMP↑, 3,   CPT1A↑, 1,   FABP4↓, 1,   FAO↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GPI↑, 1,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HK2↑, 1,   LDHA↑, 1,   lipidLev↓, 1,   NAD↓, 1,   NADPH↓, 3,   PFKL↑, 1,   PKM1↑, 1,   PKM2↑, 1,   PONs↓, 1,   SIRT1↑, 9,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 1,   Apoptosis↓, 167,   mt-Apoptosis↓, 1,   ASC?, 1,   ASC↓, 2,   BAD↓, 2,   BAX↓, 23,   BAX↑, 4,   Bax:Bcl2↓, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-2↑, 24,   Bcl-2↝, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp1↓, 3,   Casp12↓, 3,   Casp3↓, 35,   Casp3↑, 1,   cl‑Casp3↓, 8,   proCasp3↑, 1,   Casp8↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 10,   cl‑Casp9↓, 3,   Cyt‑c↓, 10,   Cyt‑c↑, 2,   Fas↓, 1,   Ferroptosis↓, 6,   iNOS↓, 17,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   p‑p38↓, 3,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 14,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 4,   AMPKα↑, 1,   CREB↑, 3,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 3,   IKKα↓, 1,   JAK2↑, 1,   JNK↓, 6,   JNK↑, 1,   p‑JNK↓, 3,   MAPK↓, 11,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 9,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Src↓, 1,   STAT↓, 1,   STAT3↑, 1,   STAT3↝, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cJun↓, 1,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   HDAC↑, 1,   miR-34a↓, 1,   other↓, 3,   other↑, 5,   other↝, 5,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   ER Stress↓, 14,   GRP78/BiP↓, 8,   HSP70/HSPA5↑, 2,   HSP90↑, 1,   IRE1↓, 2,   PERK↓, 1,   UPR↓, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3II↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 1,   PARK2↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 6,   DNArepair↑, 1,   P53↓, 2,   PARP↓, 2,   p‑PARP↓, 1,   cl‑PARP↓, 3,   cl‑PARP1↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   CEBPA↓, 1,   Diff↑, 2,   IGF-1↑, 1,   neuroG↑, 3,   TumCG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 2,   AP-1↓, 1,   BACH1↓, 1,   Ca+2↓, 8,   Ca+2↑, 1,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 2,   Cartilage↑, 1,   FNDC5↑, 1,   MMP13↓, 1,   MMP9↓, 2,   MMP9↑, 2,   N-cadherin↑, 2,   ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 4,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   eNOS↑, 2,   HIF-1↓, 1,   Hif1a↑, 1,   Hif1a↝, 1,   HIF2a↑, 1,   NO↓, 14,   VCAM-1↓, 3,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB?, 2,   BBB↓, 1,   BBB↑, 8,   BBB↝, 2,   BBB∅, 2,   CLDN1↓, 1,   CLDN4↑, 1,   CLDN5↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 3,   memfluid↑, 1,   MMP↓, 2,   MMP↑, 21,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 4,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,   VGCC↝, 1,   ZO-1↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 1,   BALF-Lym↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD8+↑, 2,   COX2/PTGS2↓, 16,   CXCL15↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 5,   IL10↑, 5,   IL13↓, 1,   IL13↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 24,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 1,   IL4↓, 3,   IL4↑, 2,   IL6↓, 27,   IL6↑, 1,   IL8↓, 3,   Imm↓, 1,   Imm↑, 2,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 74,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 6,   Neut↓, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NLRP3↓, 10,   NOD1↓, 1,   PAF↓, 1,   PGE2↓, 6,   RAGE↓, 1,   TLR1↓, 1,   TLR4↓, 4,   TNF-α↓, 40,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 3,   AChE↓, 13,   ADAM10↑, 2,   BChE↓, 4,   BDNF↓, 2,   BDNF↑, 14,   BDNF∅, 2,   ChAT↑, 1,   CHRM1↑, 1,   DA↑, 1,   MAOA↓, 2,   MAOB↓, 3,   NGF↑, 2,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APOE4↓, 1,   APP↓, 6,   cl‑APP↑, 1,   Aβ↓, 29,   Aβ42↓, 3,   BACE/β-secretase↓, 8,   BACE/β-secretase↑, 1,   IDE↑, 1,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 3,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 12,   BioAv↝, 5,   ChemoSen↑, 2,   Dose?, 3,   Dose↓, 1,   Dose↑, 2,   Dose↝, 12,   eff↑, 12,   GSTA1↑, 1,   Half-Life↓, 1,   Half-Life↝, 2,   RadioS↑, 1,   selectivity↑, 2,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALB↝, 1,   ALP↓, 1,   anemia↓, 1,   AST↓, 9,   Bil↓, 1,   BloodF↑, 1,   BP↓, 1,   BUN?, 1,   BUN↓, 3,   creat↓, 5,   CRP↓, 2,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 27,   IL6↑, 1,   IRes↓, 1,   LDH↓, 4,   RAGE↓, 1,   RBC↑, 1,   SpO2↑, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 1,   AntiTum↑, 2,   cachexia↓, 1,   cardioP?, 1,   cardioP↑, 16,   chemoP↑, 9,   cognitive↑, 35,   hepatoP↓, 1,   hepatoP↑, 19,   Learn↑, 4,   memory↑, 24,   Mood↑, 2,   motorD↑, 7,   neuroP↑, 68,   Obesity↓, 1,   OS↑, 3,   Pain↓, 2,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 17,   Risk↓, 3,   Sleep↑, 1,   Strength↑, 2,   Stroke↓, 9,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 470

Scientific Paper Hit Count for: Apoptosis, Apoptosis
7 Quercetin
6 Hydrogen Gas
6 isoorientin
6 Luteolin
6 Magnetic Fields
5 isoquercitrin
5 EGCG (Epigallocatechin Gallate)
5 Urolithin
4 Ashwagandha(Withaferin A)
4 Cisplatin
4 Hyperoside
4 Isovitexin
4 Lycopene
3 Baicalein
3 Berberine
3 doxorubicin
3 Ginkgo biloba
3 Licochalcone A
3 Resveratrol
3 Taurine
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Betulinic acid
2 Boron
2 α-Bisabolol / Chamomile oil
2 Carvacrol
2 Chrysin
2 Cichoric acid / Chicoric acid
2 Crocetin
2 Diindolylmethane
2 Dandelion Root
2 Ginkgo biloba-EGb 761
2 Emodin
2 Gallic acid
2 Ginkgolide B
2 hydrogen sulfide
2 Honokiol
2 Isoliquiritigenin
2 L-Theanine
2 Lactoferrin/Talactoferrin
2 Matrine
2 Morin
2 Parthenolide
2 Selenium NanoParticles
2 Shikonin
2 Vitamin K2
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Rutin
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 Astaxanthin
1 Beta-Caryophyllene
1 borneol
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Choline
1 methotrexate
1 Citicoline, CDP-Choline
1 Coenzyme Q10
1 Curcumin
1 diet Short Term Fasting
1 Indole-3-carbinol
1 D-limonene
1 Ferulic acid
1 Formononetin
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 HydroxyCitric Acid
1 Orlistat
1 Huperzine A/Huperzia serrata
1 Butein
1 Scopoletin
1 Isorhamnetin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Kaempferol
1 Linalool
1 Mung Bean Sprouts
1 Magnolol
1 Mangiferin
1 Melatonin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 nicotinamide adenine dinucleotide
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Rosmarinic acid
1 Radiotherapy/Radiation
1 Silymarin (Milk Thistle) silibinin
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:14  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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