VDAC1 Cancer Research Results

VDAC1, Voltage-Dependent Anion Channel 1: Click to Expand ⟱
Source:
Type:
VDAC1 is a pore-forming protein in the outer mitochondrial membrane that regulates metabolite flux (ATP/ADP, ions), mitochondrial–cytosolic communication, and apoptosis signaling. In Alzheimer’s disease, VDAC1 sits at a convergence point between mitochondrial dysfunction, oxidative stress, and neuronal death, all core features of AD pathophysiology.
-Upregulated VDAC1 detected in AD post-mortem cortex and hippocampus.
Scientific Papers found: Click to Expand⟱
7982- itraC,    Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- in-vitro, Nor, HUVECs - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
angioG↓, mTOR↓, NPC1L1↓, AMPK↑, VDAC1↓,
7983- itraC,    Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
- in-vitro, Nor, HUVECs
angioG↓, VDAC1↓, mt-ATP↓, AMPK↑, mTOR↓, TumCP↓,
8089- KAE,    Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, B16-F10
TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

VDAC1↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mt-ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   NPC1L1↓, 1,   Pyruv↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↝, 1,   mTOR↓, 2,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

PARK2↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,   PTEN↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: VDAC1, Voltage-Dependent Anion Channel 1
2 itraconazole
1 Kaempferol
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1405  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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