TRAF1 Cancer Research Results

TRAF1, TNF Receptor–Associated Factor 1: Click to Expand ⟱
Source:
Type:
TRAF1 is an adaptor protein in TNF receptor superfamily signaling that modulates NF-κB, MAPK, and apoptotic pathways. Unlike other TRAFs, TRAF1 lacks intrinsic E3 ubiquitin ligase activity, acting instead as a regulatory scaffold. In cancer, TRAF1 is best viewed as a pro-survival, anti-apoptotic signal amplifier, especially in immune-related and hematologic malignancies.
Expression Pattern in Cancer
-Low or absent in most normal tissues
-Inducible by NF-κB
-Overexpressed in many cancers, especially:
  -B-cell lymphomas (CLL, Hodgkin lymphoma, DLBCL)
  -Multiple myeloma
  -Some solid tumors with inflammatory microenvironments
-High TRAF1 expression correlates with:
-Therapy resistance
-Immune-evasive phenotypes
-Poor prognosis (context-dependent)


Scientific Papers found: Click to Expand⟱
6531- CRV,    D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats
- in-vivo, Nor, NA
*TRAF1↓, *IL1β↓, *TNF-α↓, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *Inflam↓, *NRF2↑, *Bcl-2↑, *IL8↓, *antiOx↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL8↓, 1,   Inflam↓, 1,   TNF-α↓, 1,   TRAF1↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: TRAF1, TNF Receptor–Associated Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1437  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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