LIMK1 Cancer Research Results

LIMK1, LIM domain kinase 1: Click to Expand ⟱
Source:
Type:

LIM domain kinase 1 (LIMK1) is a serine/threonine kinase that regulates actin-cytoskeleton dynamics primarily by phosphorylating and inactivating cofilin. LIMK1 acts downstream of Rho-family GTPases and kinases including ROCK and PAK. In many cancers, LIMK1 expression or activity ↑ promotes actin polymerization, cell migration, invasion, epithelial-mesenchymal transition, and metastatic progression. Conversely, LIMK1 inhibition or activity ↓ commonly reduces cancer-cell motility and invasion. Gene reference.



Scientific Papers found: Click to Expand⟱
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LIMK1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LIMK1, LIM domain kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1547  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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