FFA/NEFA Cancer Research Results

FFA/NEFA, Free fatty acids — FFA / non-esterified fatty acids, NEFA: Click to Expand ⟱
Source:
Type: Biomarker 
Free fatty acids may be measured in plasma, tumour tissue, culture medium, or intracellular lipid pools. They provide substrates for:

β-oxidation and ATP production;
membrane lipid synthesis;
lipid signalling;
eicosanoid production;
protein acylation.

However, excessive FFAs can cause lipotoxicity, ROS generation, ER stress, lipid peroxidation, or ferroptosis. Therefore, FFA ↑ is not automatically tumour-promoting or beneficial.


Scientific Papers found: Click to Expand⟱
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
9086- MGF,    Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial
- Trial, Obesity, NA
*Dose↝, *TG/TAG↓, *FFA/NEFA↓, *IRes↓,
9058- PatchO,    Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
- in-vivo, LiverDam, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *LDH↓, *ROS↓, *TNF-α↓, *FFA/NEFA↓, *TG/TAG↓, *GSH↑, *GSR↑, *SOD↑, *GSH/GSSG↑, *AMPK↑, *PPARα↑, *CPT1A↑, *NF-kB↓, *SREBP1/SREBF1↓, *Fas↓, *SCD1↓, *lipid-P↓,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   PI3K↓, 1,   STK11/LKB1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   GSH/GSSG↑, 1,   GSR↑, 1,   HDL↑, 1,   lipid-P↓, 1,   MPO↓, 1,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   CPT1A↑, 1,   FASN↓, 1,   FFA/NEFA↓, 4,   glucose↝, 1,   LDL↓, 2,   PLA2↓, 1,   SCD1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Fas↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 3,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   IRes↓, 2,   LDH↓, 1,   TG/TAG↓, 3,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiArt↑, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 44

Scientific Paper Hit Count for: FFA/NEFA, Free fatty acids — FFA / non-esterified fatty acids, NEFA
1 Inositol
1 Mangiferin
1 Patchouli Oil (Pogostemon cablin)
1 Rutin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1551  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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