IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
9258- Acai, EO,    Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
- in-vivo, CRC, NA
Risk↓, *MPO↓, *TNF-α↓, *IL1β↓, *IL6↓, *PCNA↓, *Bcl-2↓, *cl‑Casp3↓, *COX2/PTGS2?,
4360- AgNPs,    Silver Nanoparticles as Real Topical Bullets for Wound Healing
- Study, Nor, NA
*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↓, *PI3K↑, *Akt↑, *mTOR↑,
6403- ANE,    Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease
- in-vivo, Nor, NA
*LDH↓, *IL6↓, *TNF-α↓, *BP↓,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, Var, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1/CCL2↓, *NO↓, *iNOS↓, *IκB↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5418- ASTX,    Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*MDA↓, *SOD↑, *IL6↓, *ROS↓, *Inflam↓,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, AD, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6506- BCP,    Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
- vitro+vivo, Nor, HMC3
*neuroP↑, *NF-kB↓, *SIRT1↑, *PGC-1α↓, *BDNF↓, *TNF-α↓, *IL6↓, *IL10↑, *Inflam↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *Synergy↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, Synergy↑, other↝,
699- Bor,    Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *TNF-α↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *Sema3A/PlexinA1↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3520- Bor,    Effect of boron element on photoaging in rats
- in-vivo, Nor, NA
*hepatoP↑, *BMD↑, *COX2/PTGS2↓, *IL8↓, *NF-kB↓, *IL6↓, *TNF-α↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
8973- BRice,    Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
- in-vitro, Nor, RAW264.7
*Ingr↝, *Inflam↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *NF-kB↓, *AP-1↓, *p‑ERK↓, *p‑p38↓, *p‑JNK↓, *MAPK↓,
8974- BRice,    Impact of anthocyanin-rich black rice consumption on cognitive function, inflammation and microvascular function in older adults: a crossover intervention trial
- Trial, AD, NA
*Dose↝, *Dose↝, *memory↑, *IL6↓, *cognitive↑, *Inflam↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,

Showing Research Papers: 1 to 50 of 279
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 279

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 3,   GPx4↓, 1,   GSH↓, 3,   GSH↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Iron↑, 1,   Iron↝, 1,   lipid-P↑, 1,   MDA↑, 2,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 4,   ROS↓, 8,   ROS↑, 31,   SOD?, 1,   SOD↓, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACLY↓, 1,   AMPK↓, 2,   AMPK↑, 4,   ATP↓, 3,   ATP↑, 1,   BHB↑, 1,   FASN↓, 1,   FDG↓, 1,   GlucoseCon↓, 3,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 1,   HMGCS2↑, 1,   lactateProd↓, 2,   LDHA↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 34,   ASC↑, 1,   BAD↓, 1,   Bak↓, 1,   Bak↑, 1,   BAX↑, 13,   BAX⇅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 21,   Bcl-xL↓, 3,   BID↑, 1,   BIM↑, 1,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 6,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 26,   cl‑Casp3↑, 5,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 7,   cl‑Casp8↑, 1,   Casp9↑, 13,   cl‑Casp9↑, 5,   cFLIP↓, 2,   Cyt‑c↑, 10,   Diablo↑, 1,   DR5↓, 1,   DR5↑, 1,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 2,   Mcl-1↓, 1,   MDM2↓, 2,   necrosis↑, 1,   p38↓, 1,   p38↑, 2,   Perforin↝, 1,   Pyro↑, 1,   survivin↓, 8,   TumCD↓, 1,   TumCD↑, 3,   XIAP↓, 4,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 26,   Akt↑, 2,   p‑Akt↓, 6,   Akt2↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 5,   EGFR↑, 1,   ERK↓, 4,   p‑ERK↓, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   JAK↓, 2,   JAK2↓, 4,   JNK↓, 1,   JNK↑, 3,   MAPK↓, 3,   MAPK↑, 1,   MARK4↓, 1,   MKK4↓, 1,   mTOR↓, 17,   p‑mTOR↓, 1,   P70S6K↓, 2,   PI3K↓, 25,   p‑PI3K↓, 1,   PKCδ↓, 1,   PTEN↑, 2,   RAS↑, 1,   Sp1/3/4↓, 1,   STAT↓, 2,   STAT3↓, 14,   p‑STAT3↓, 2,   STAT4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↓, 2,   cMyc↓, 5,   cMyc↑, 1,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 2,   FOXO3↑, 2,   FOXO3↝, 1,   HATs↓, 1,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 1,   miR-124-3p↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   OCT4↓, 3,   other?, 1,   other↑, 2,   other↝, 2,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP90↓, 4,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 2,   TumAuto↑, 7,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 10,   P53↓, 2,   P53↑, 11,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↓, 1,   cl‑PARP↑, 5,   PCNA↓, 8,   Telomerase↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 6,   CDK4↑, 1,   CDK6↓, 2,   CDK6↑, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 15,   cycE/CCNE↓, 2,   E2Fs↓, 2,   Ki-67↓, 6,   mitA↑, 1,   P21↑, 8,   p27/CDKN1B↑, 1,   pRB↓, 1,   p‑RB1↓, 1,   TumCCA↑, 29,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 6,   Diff↓, 1,   FGF↓, 1,   IGF-1?, 1,   Ki-67↓, 6,   Nestin↓, 1,   NOTCH↑, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   Shh↓, 1,   TumCG↓, 14,   TumCP↓, 20,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   BACH1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   Cofilin↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 11,   EMT↝, 1,   EpCAM↓, 2,   p‑FAK↓, 1,   fascin↓, 1,   GIT1↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 11,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 15,   MMPs↓, 8,   N-cadherin↓, 6,   RECK↑, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 14,   TumCMig↓, 15,   TumMeta↓, 11,   TumMeta↑, 1,   Twist↓, 2,   uPA↓, 1,   Vim↓, 4,   Zeb1↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 13,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   Hif1a↓, 9,   NO↓, 1,   VEGF↓, 21,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,   MMP↓, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 12,   CXCR4↓, 3,   FOXP3↑, 1,   HCAR2↑, 2,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL1↑, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 4,   IL6↑, 1,   IL8↓, 2,   Imm↑, 5,   Inflam↓, 9,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 23,   NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 3,   NLRP3↑, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 3,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   PPARγ↓, 3,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 4,   ChemoSen↑, 32,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 10,   eff↓, 2,   eff↑, 7,   eff⇅, 1,   eff↝, 1,   eff∅, 1,   Half-Life↓, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   RadioS↑, 7,   selectivity↑, 8,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   AR↓, 2,   CA19-9↓, 1,   CEA↓, 2,   CRP↓, 2,   EGFR↓, 5,   EGFR↑, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 4,   IL6↑, 1,   LDH↓, 2,   LDH↑, 1,   PD-L1↓, 1,   PSA↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 11,   antiNeop↑, 1,   AntiTum↑, 4,   Appetite↑, 1,   cardioP↑, 3,   chemoP↑, 15,   chemoPv↑, 1,   cognitive?, 1,   cognitive↑, 3,   hepatoP↑, 2,   K17↓, 1,   neuroP↑, 3,   NP/CIPN↓, 2,   OS↑, 2,   Pain↓, 2,   PFS↑, 1,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 4,   Risk↓, 5,   Sleep↑, 1,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 5,   TumW↓, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 4,  
Total Targets: 407

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 5,   antiOx↑, 93,   ARE↑, 3,   Bil↑, 1,   Catalase↑, 65,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 1,   GCLC↝, 1,   GCLM↑, 1,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 43,   GPx1↑, 2,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 67,   GSR↓, 2,   GSR↑, 4,   GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 11,   H2O2↓, 4,   HDL↓, 1,   HDL↑, 4,   HDL∅, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 67,   HO-1↝, 1,   hyperG↝, 1,   Iron↓, 2,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 51,   lipid-P↑, 2,   MDA↓, 72,   MPO↓, 14,   NFE2L2↓, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 6,   NQO1↑, 15,   NQO1↝, 1,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 3,   NRF2↑, 90,   RNS↓, 6,   ROS?, 3,   ROS↓, 174,   ROS↑, 2,   ROS↝, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 2,   SOD↓, 1,   SOD↑, 94,   SOD1↑, 5,   SOD2↑, 3,   TAC↑, 12,   TBARS↓, 5,   Thiols↑, 1,   TOS↓, 1,   Trx↑, 1,   TrxR↑, 2,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 2,   VitE↓, 1,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↓, 1,   IronCh↑, 7,   NCOA4↝, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   FIS1↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OXPHOS↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 5,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 9,   ACADS/SCAD↑, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 2,   ALAT↓, 29,   AMPK↓, 1,   AMPK↑, 16,   ATP↓, 1,   ATP↑, 10,   cAMP↑, 4,   CPT1A↑, 1,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   glucose↓, 7,   GlucoseCon↑, 2,   GSK‐3β↓, 12,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 2,   KeyT↝, 1,   LDL↓, 12,   lipidLev↓, 2,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 5,   NADPH↑, 3,   PKM2↓, 1,   SIRT1↑, 20,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 27,   ASC↓, 3,   BAD↓, 1,   BAX↓, 18,   BAX↑, 1,   Bax:Bcl2↓, 4,   Bcl-2↓, 5,   Bcl-2↑, 13,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 5,   Casp12↓, 2,   Casp3↓, 32,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 4,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 14,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 66,   iNOS↑, 4,   MLKL↓, 1,   necrosis↓, 2,   p38↓, 10,   p‑p38↓, 3,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 10,   Akt↑, 11,   p‑Akt↑, 4,   AKT1↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 4,   p‑CREB↑, 2,   EGFR↓, 2,   ERK↓, 14,   ERK↑, 2,   p‑ERK↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 3,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 2,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 12,   JNK↑, 1,   p‑JNK↓, 6,   MAPK?, 1,   MAPK↓, 21,   MAPK↑, 2,   p‑MAPK↓, 1,   p‑MKK4↑, 1,   mTOR↓, 5,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 7,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 3,   PTEN↑, 1,   RIP1↓, 2,   STAT↓, 2,   STAT3↓, 7,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   other↓, 4,   other↑, 14,   other↝, 17,   other∅, 1,   RUNX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 9,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 10,   GRP78/BiP↓, 7,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 2,   UPR↑, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 2,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 7,   P53↓, 3,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   Choline↑, 2,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   Ki-67↓, 1,   MSCs↑, 1,   neuroG↑, 5,   p‑STAT1↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 4,   AP-1↓, 6,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 5,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 6,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP-10↝, 1,   MMP1↓, 2,   MMP13↓, 3,   MMP2↓, 7,   MMP2↑, 1,   MMP3↓, 4,   MMP9↓, 13,   MUC1↑, 3,   Na+↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 2,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 5,   TGF-β↑, 7,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   uPA↑, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 5,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   angioG↝, 1,   E-sel↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 2,   NO↓, 45,   NO↑, 1,   VCAM-1↓, 9,   VEGF↓, 5,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 22,   BBB↝, 4,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 3,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 1,   GastroP↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 13,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   Na+↑, 1,   OCLN↓, 1,   OCLN↑, 5,   TJ↑, 4,   TRPC1↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 8,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 85,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   FOXP3↑, 1,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 17,   IFN-γ↑, 3,   IL1↓, 15,   IL10↓, 15,   IL10↑, 24,   IL12↓, 11,   IL17↓, 11,   IL18↓, 6,   IL1β↓, 137,   IL2↓, 8,   IL2↑, 1,   IL22↓, 1,   IL23↓, 2,   IL33↓, 2,   IL4↓, 5,   IL4↑, 7,   IL5↓, 2,   IL5↑, 1,   IL6↓, 283,   IL6↑, 2,   IL8↓, 33,   IL8↑, 1,   Imm↓, 1,   Imm↑, 8,   Imm↝, 1,   INF-γ↓, 2,   Inflam↓, 188,   Inflam↑, 1,   IP-10/CXCL-10↓, 2,   IRF3↓, 2,   LPS↓, 2,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 15,   MCP1/CCL2↑, 1,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 3,   MyD88↓, 5,   NeuroI↓, 6,   NF-kB↓, 114,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 32,   NOD1↓, 1,   p65↓, 2,   p‑p65↓, 1,   PGD2↓, 1,   PGE1↓, 1,   PGE2↓, 37,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 4,   TLR4↓, 20,   TLR4↑, 1,   TNF-α↓, 223,   TNF-α↑, 3,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 8,   AChE↓, 21,   ADAM10↑, 1,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 28,   BrainVol↑, 1,   ChAT↑, 4,   ChE↓, 1,   DA↑, 1,   GABA↓, 1,   GABA↑, 1,   GABA↝, 1,   MAOA↓, 4,   MAOB↓, 1,   NGF↑, 5,   PSD95?, 1,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN1↑, 1,   SYP↑, 1,   SYT1↑, 1,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APOE4↓, 1,   APP↓, 5,   cl‑APP↑, 1,   Aβ↓, 37,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 11,   p‑tau↓, 15,   XO↓, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   BNP↓, 1,   DHT↓, 1,   END↑, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 8,   p‑PPARγ↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 45,   BioAv⇅, 1,   BioAv↝, 26,   BioEnh↑, 4,   ChemoSen↑, 2,   CompStab↑, 2,   CompStab↝, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 2,   Dose↝, 51,   eff↓, 1,   eff↑, 26,   eff↝, 2,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 11,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 26,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 29,   ALB↑, 1,   ALP↓, 5,   anemia↓, 1,   AST↓, 28,   BG↓, 3,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 4,   BP↓, 11,   BUN?, 1,   BUN↓, 4,   colonLen↑, 1,   creat↓, 13,   CRP↓, 12,   EGFR↓, 2,   Ferritin↓, 1,   Hcy/homoC↓, 2,   Hcy/homoC↝, 1,   HemoG↑, 2,   hs-CRP↓, 1,   IL6↓, 283,   IL6↑, 2,   KeyT↝, 1,   LDH↓, 10,   LDH↑, 1,   NOS2↓, 1,   PSA↓, 1,   RAGE↓, 1,   RBC↑, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 13,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 2,   AntiDiabetic↑, 20,   antiPs↑, 3,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 52,   chemoP↑, 10,   chemoPv↑, 3,   cognitive↑, 56,   cognitive↝, 1,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 49,   Learn↑, 6,   memory↑, 36,   Mood↑, 2,   motorD↓, 1,   motorD↑, 6,   neuroP↑, 112,   NP/CIPN↓, 1,   Obesity↓, 11,   OS↑, 4,   Pain↓, 9,   QoL↑, 2,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 23,   Risk↓, 3,   Sleep↑, 4,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 14,   toxicity↓, 18,   toxicity↝, 5,   toxicity∅, 3,   Weight↓, 1,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 5,   AntiViral↑, 7,   Bacteria↓, 12,   Diar↓, 2,   GutMicro↑, 33,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 1,   Ingr↝, 9,  
Total Targets: 654

Scientific Paper Hit Count for: IL6, Interleukin-6
16 Hydrogen Gas
9 Curcumin
9 Lycopene
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 isoorientin
7 Magnetic Fields
7 Thymoquinone
6 EGCG (Epigallocatechin Gallate)
5 Alpha-Lipoic-Acid
5 Luteolin
5 Shikonin
4 Artemisinin
4 Baicalein
4 Cisplatin
4 Beta-Caryophyllene
4 Boron
4 α-Bisabolol / Chamomile oil
4 Eugenol
4 Folic Acid, Vit B9
4 Isoliquiritigenin
4 Matrine
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Ferulic acid
3 Hyperoside
3 Isovitexin
3 Kaempferol
3 Lactoferrin/Talactoferrin
3 Morin
3 Propolis -bee glue
3 Pterostilbene
2 Allicin (mainly Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Astaxanthin
2 Berberine
2 Selenium
2 Black Rice, Oryza sativa
2 Butyrate
2 Capsaicin
2 Chlorogenic acid
2 Coenzyme Q10
2 Crocetin
2 Piperine
2 eicosapentaenoic acid
2 diet Fermented Foods
2 Emodin
2 Vitamin B12
2 Formononetin
2 Gallic acid
2 Chemotherapy
2 Honokiol
2 lambertianic acid
2 Magnolol
2 Moringa oleifera
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Resveratrol
2 Rutin
2 Selenium NanoParticles
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Açaí, Euterpe oleracea
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 Baicalin
1 Biochanin A
1 xanthohumol
1 Betulinic acid
1 Bacopa monnieri
1 borneol
1 buckwheat sprouts
1 Caffeic acid
1 Carvacrol
1 Carnosine
1 Celastrol
1 Chyawanprash
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Sesame seeds and Oil
1 Fisetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Orlistat
1 Hops (Humulus lupulus)
1 Inositol
1 isoquercitrin
1 Juglone
1 Potassium
1 L-Theanine
1 Licochalcone A
1 Licorice
1 SDG/lignans
1 Linalool
1 Mung Bean Sprouts
1 Magnetic Field Rotating
1 Moringin
1 Melatonin
1 Methylene blue
1 5-fluorouracil
1 Nimbolide
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Phycocyanin
1 Piperlongumine
1 Phosphatidylserine
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 Vitamin B3,Niacin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:158  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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