Iron Cancer Research Results

Iron, Iron: Click to Expand ⟱
Source:
Type:
Iron is an essential nutrient that is crucial for various cellular processes, including DNA synthesis, cell proliferation, and oxygen transport.
Cancer cells often have increased iron requirements due to their rapid growth and proliferation. Some tumors can acquire iron through various mechanisms, including upregulating iron transport proteins. This can support their growth and survival.
Excess iron can lead to the production of reactive oxygen species (ROS) through Fenton reactions, which can cause oxidative damage to DNA, proteins, and lipids. This oxidative stress can contribute to cancer development and progression.
Scientific Papers found: Click to Expand⟱
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
5883- CAR,    Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study
- Trial, Nor, NA
*Dose↝, *HDL↓, *Bil↓, *Iron↓, *toxicity↓,
8998- Citicoline,  Rad,    The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *compI↑, *compIII↑, *ATP↑, *Ca+2↓, *Iron↓, *Casp3↓, *glucose↝, *ACE/ACE1↑, *AChE↓,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, AD, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
7562- HYP,  doxoR,    Hyperoside Inhibits Doxorubicin-Induced Ferroptosis in Cardiomyocytes via the Nrf2/GPX4 Pathway
- in-vivo, Nor, NA
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
7698- IP6,    Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability-A Narrative Review of Human Interventions
- Review, Nor, NA
*Iron↓, *Zn2+↓, *other↝, *IronCh↑,
7700- IP6,    A84 THE USE OF PHYTASE TO ENHANCE DIETARY IRON AND ZINC ABSORPTION - A SCOPING REVIEW
- Review, Nor, NA
*Iron↓, *eff↑,
7766- ISL,    Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice
- in-vivo, Stroke, NA
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
1777- MLT,    Melatonin as an antioxidant: under promises but over delivers
- Review, Var, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
8882- MOR,  Cisplatin,    Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose?, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑, *MDA↓, *other↑, *Ferroptosis↓, *Iron↓, *ROS↓, *other↓, ChemoSen↑, *chemoP↑, *selectivity↑,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,

Showing Research Papers: 1 to 19 of 19

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PKM2↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Cyt‑c↑, 1,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   Pyro↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   ERK↑, 1,   JNK↑, 1,   MARK4↓, 1,   mTOR↓, 1,   PI3K↓, 1,   p‑PI3K↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC2↓, 1,   miR-155↓, 1,   OCT4↓, 1,   SOX4↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Gli1↓, 1,   Nanog↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP2↓, 2,   MMP9↓, 3,   N-cadherin↓, 1,   TIMP2↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 1,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   DR4↑, 1,   Imm↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 4,   eff↑, 2,   MDR1↓, 1,   selectivity↑, 1,   Synergy↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,   chemoP↑, 1,  
Total Targets: 69

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 5,   Bil↓, 1,   Catalase↑, 3,   Copper↓, 2,   Fenton↓, 1,   GPx↑, 6,   GPx4↓, 1,   GPx4↑, 4,   GSH↑, 4,   GSR↑, 1,   HDL↓, 1,   HO-1↓, 1,   HO-1↑, 2,   HO-1↝, 1,   Iron↓, 16,   i-Iron↓, 3,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↓, 7,   NOX↓, 1,   NRF2↓, 1,   NRF2↑, 6,   ROS↓, 15,   SOD↓, 1,   SOD↑, 6,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTL↓, 1,   IronCh↑, 4,   NCOA4↝, 1,   TfR1/CD71↓, 2,   Zn2+↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   mtDam↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 3,   ATP↑, 1,   glucose↝, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Casp3↑, 1,   Ferroptosis↓, 7,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   JNK↓, 1,   PKA↑, 1,   PKCδ?, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Zn2+↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB↝, 1,   CLDN4↑, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 4,   NF-kB↓, 1,   RAGE↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 2,   PSD95↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose?, 2,   Dose↝, 2,   eff↑, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Bil↓, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↑, 1,   IL6↓, 2,   LDH↑, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   CardioT↓, 1,   chemoP↑, 1,   cognitive↑, 3,   motorD↑, 1,   neuroP↑, 5,   RenoP↑, 2,   Stroke↓, 2,   toxicity↓, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 108

Scientific Paper Hit Count for: Iron, Iron
2 Huperzine A/Huperzia serrata
2 phytic acid, Inositol hexakisphosphate
2 Cisplatin
1 Alpha-Lipoic-Acid
1 Carvacrol
1 Citicoline, CDP-Choline
1 Radiotherapy/Radiation
1 HydroxyCitric Acid
1 Hyperoside
1 doxorubicin
1 Isoliquiritigenin
1 Kaempferol
1 Licochalcone A
1 Matrine
1 Melatonin
1 Morin
1 Myricetin
1 Mung Bean Sprouts
1 Quercetin
1 Rosmarinic acid
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:160  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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