PLA2 Cancer Research Results

PLA2, Phospholipase A2: Click to Expand ⟱
Source:
Type:

PLA2 - Phospholipase A2

Abbreviation: PLA2

Type: Phospholipase / lipid-metabolizing enzyme family

Function: Hydrolyzes the sn-2 fatty-acid bond of membrane phospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids. PLA2 activity regulates eicosanoid production, inflammation, membrane remodeling, cell signaling, proliferation, and oxidative responses.

Cancer: ↑ Generally increased/pro-tumorigenic for several important PLA2 isoforms, particularly cPLA2α (PLA2G4A) and selected secreted PLA2 enzymes. Increased PLA2 signaling can promote arachidonic-acid/eicosanoid production, inflammation, angiogenesis, tumor growth, invasion, metastasis, and tumor-microenvironment signaling.

Alzheimer's Disease: ↑ Increased or overactivated cPLA2/arachidonic-acid signaling has been associated with Aβ-induced neurotoxicity, neuroinflammation, synaptic dysfunction, and cognitive impairment.
Scientific Papers found: Click to Expand⟱
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   DR5↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

LIMK1↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-34a↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Pain↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   HDL↑, 1,   lipid-P↓, 1,   MDA↓, 1,   MPO↓, 1,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FFA/NEFA↓, 1,   LDL↓, 1,   PLA2↓, 2,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   mTOR↑, 1,   PI3K↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↓, 1,   IL4↓, 1,   IL5↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   hepatoP↑, 1,   Mucositis↓, 1,   neuroP↑, 1,   RenoP↑, 1,   Stroke↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 43

Scientific Paper Hit Count for: PLA2, Phospholipase A2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1615  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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