PSEN1/PS1 Cancer Research Results

PSEN1/PS1, Presenilin-1: Click to Expand ⟱
Source:
Type:

PSEN1 - Presenilin-1

Abbreviation: PSEN1, PS1

Type: Intramembrane aspartyl protease / catalytic subunit of the γ-secretase complex

Function: PSEN1 is the principal catalytic component of the γ-secretase complex, which performs intramembrane proteolysis of numerous substrates including amyloid precursor protein (APP) and NOTCH receptors. APP cleavage by PSEN1-containing γ-secretase generates amyloid-β peptides including Aβ40 and Aβ42. PSEN1 also regulates cellular signaling, membrane-protein processing, calcium homeostasis, and neuronal function.

Cancer: ↕ Context-dependent. PSEN1-dependent γ-secretase activity can promote oncogenic signaling through cleavage and activation of NOTCH receptors and other substrates. γ-Secretase inhibition can suppress NOTCH-driven proliferation, survival, stemness, and tumor progression in selected cancers, although PSEN1 function varies substantially according to tumor type and substrate context.

Alzheimer's Disease: ↕ Pathogenic alteration of PSEN1 function is a major cause of autosomal-dominant early-onset Alzheimer's disease. Disease-causing PSEN1 mutations alter γ-secretase processivity and commonly increase the relative production of longer, aggregation-prone Aβ species, particularly the Aβ42/Aβ40 ratio. Many pathogenic mutations reduce overall γ-secretase cleavage efficiency, so Alzheimer's disease is better characterized by abnormal PSEN1 function than by a simple increase or decrease in PSEN1 expression.
Scientific Papers found: Click to Expand⟱
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, *Obesity↓, *Leptin↓, *adiP↑, *hepatoP↑, *PSEN1/PS1↓, *PSEN2/PS-2↓, *BACE/β-secretase↓, *Synergy↑,
7498- H2S,    Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse
- in-vivo, AD, NA
*BACE/β-secretase↑, *ADAM17↑, *PSEN1/PS1↓, *PI3K↑, *Akt↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8870- MOR,    Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms
- in-vivo, AD, NA
*neuroP↑, *Learn↑, *memory↑, *Aβ↓, *APP↝, *ADAM10↑, *BACE/β-secretase↓, *PSEN1/PS1↓, *p‑tau↓, *CDK5↓, *cognitive↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   H2O2↓, 1,   lipid-P↓, 1,   MDA↓, 1,   Nrf1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   GSK‐3β↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑CREB↑, 1,   PI3K↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   NeuroI↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,   GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 1,   ChAT↑, 1,   PSD95↑, 1,   RELN↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   APP↝, 1,   Aβ↓, 2,   BACE/β-secretase↓, 3,   BACE/β-secretase↑, 1,   PSEN1/PS1↓, 4,   PSEN2/PS-2↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   hepatoP↑, 1,   Learn↑, 2,   memory↑, 2,   neuroP↑, 2,   Obesity↓, 1,   Sleep↑, 1,  
Total Targets: 60

Scientific Paper Hit Count for: PSEN1/PS1, Presenilin-1
1 Acer okamotoanum
1 isoquercitrin
1 hydrogen sulfide
1 Melatonin
1 Morin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1650  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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