AHR Cancer Research Results

AHR, Airway Hyperresponsiveness: Click to Expand ⟱
Source:
Type:

Airway Hyperresponsiveness (AHR)

Aliases: Airway Hyperreactivity; Bronchial Hyperresponsiveness; Bronchial Hyperreactivity; BHR

Definition: Airway hyperresponsiveness is an exaggerated narrowing of the airways in response to bronchoconstrictive stimuli such as methacholine, histamine, allergens, cold air, or exercise.

Asthma relevance: AHR is a major physiological characteristic of asthma. In experimental asthma, it is commonly assessed by measuring airway or lung resistance following increasing doses of methacholine.

Direction:
Airway Hyperresponsiveness ↑ = adverse / characteristic of asthma
Airway Hyperresponsiveness ↓ = beneficial

Typical pathway:
Airway inflammation + epithelial dysfunction + smooth-muscle hyperreactivity → exaggerated response to bronchoconstrictor → Airway Hyperresponsiveness ↑ → Airway Resistance ↑



Scientific Papers found: Click to Expand⟱
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↓, 1,   HK2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   mt-Cyt‑c↓, 1,   IAP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PI3K↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO4↓, 1,   PAX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EIF4E↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCMig↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cachexia↓, 1,  
Total Targets: 40

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL1β↓, 1,   NF-kB↓, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   cognitive↑, 1,   Learn↑, 1,   memory↑, 1,   Stroke↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: AHR, Airway Hyperresponsiveness
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1726  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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