MUC5AC Cancer Research Results

MUC5AC, Mucin 5AC: Click to Expand ⟱
Source:
Type:

MUC5AC - Mucin 5AC

Abbreviation: MUC5AC

Type: Secreted gel-forming mucin / epithelial glycoprotein / tumor biomarker

Function: MUC5AC is a large, heavily glycosylated secreted mucin that contributes to formation of the protective mucus layer on epithelial surfaces. It regulates epithelial barrier properties, cell adhesion, host-pathogen interactions, inflammatory signaling, and interactions between epithelial cells and the extracellular environment.

Cancer: ↕ Context-dependent, with increased expression in several major adenocarcinomas. MUC5AC is frequently overexpressed or aberrantly expressed in pancreatic, esophageal, ovarian mucinous, gastric, and selected lung cancers. Elevated MUC5AC can promote tumor-cell survival, stemness, migration, invasion, immune interactions, and tumor progression. In pancreatic cancer, MUC5AC can enhance integrin αvβ5/Src/STAT3/KLF4 signaling and maintain cancer stem-like properties. However, expression and prognostic significance vary substantially by tumor type.
Scientific Papers found: Click to Expand⟱
7929- H2,    Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
- in-vivo, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *TNF-α↓, *AirwayM↓, *MUC5AC↓, *COL3A1↓, *VEGF↓, *NF-kB↓, *Inflam↓, *antiAll↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   Glycolysis↓, 1,   HK2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 1,   FasL↑, 1,   IAP1↓, 1,   p38↑, 1,   survivin↓, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   EGFR↓, 1,   ERK↑, 1,   HER2/EBBR2↓, 1,   JNK↓, 1,   mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 1,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MET↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   FOXP3↑, 1,   Imm↝, 1,   PD-L1↓, 1,   T-Cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   HER2/EBBR2↓, 1,   PD-L1↓, 1,  
Total Targets: 54

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   lipid-P↓, 1,   NRF2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Migration(tgid=13) ⓘ

COL3A1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MUC5AC↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   IL13↓, 1,   IL4↓, 1,   IL5↓, 1,   Inflam↓, 3,   NF-kB↓, 2,   TNF-α↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   antiAll↑, 2,   AntiArt↑, 1,   neuroP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: MUC5AC, Mucin 5AC
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1737  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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