SCP2 Cancer Research Results

SCP2, Sterol Carrier Protein 2: Click to Expand ⟱
Source:
Type:

SCP2 - Sterol Carrier Protein 2

Abbreviation: SCP2, SCP-2, NSL-TP

Type: Intracellular lipid-transfer protein / sterol carrier protein

Function: SCP2 is a small intracellular lipid-binding and transfer protein that participates in trafficking of cholesterol, fatty acids, phospholipids, and other lipids between cellular membranes and organelles. It is particularly associated with peroxisomal and mitochondrial lipid metabolism and contributes to cholesterol homeostasis, fatty-acid oxidation, membrane composition, and cellular lipid signaling.

Cancer: ↕ Context-dependent. Increased SCP2 can promote cholesterol trafficking, lipid metabolic reprogramming, AKT-associated survival signaling, angiogenesis, proliferation, and tumor progression in several cancers. However, SCP2 can also exert tumor-suppressive effects in selected cancers, including colon adenocarcinoma, where increased SCP2 has been associated with reduced proliferation and migration, increased apoptosis, and greater ferroptosis sensitivity.
Scientific Papers found: Click to Expand⟱
7985- itraC,    Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking
- vitro+vivo, GBM, U87MG - vitro+vivo, GBM, C6
TumCP↓, TumAuto↑, SCP2↓, AKT1↓, mTOR↓, other↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SCP2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SCP2, Sterol Carrier Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1746  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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