IQGAP3 Cancer Research Results

IQGAP3, IQ Motif Containing GTPase Activating Protein 3: Click to Expand ⟱
Source:
Type:

IQGAP3 - IQ Motif Containing GTPase Activating Protein 3

Type: Scaffold protein / cytoskeletal regulator / signaling regulator

Function: IQGAP3 is a multidomain scaffold protein that regulates cell proliferation, cytoskeletal organization, adhesion, migration, and intracellular signaling. It interacts with small GTPase- and kinase-associated signaling networks and can influence pathways including RAS/ERK and PI3K/AKT.

Cancer: ↑ Frequently overexpressed in multiple cancers and associated with increased proliferation, migration, invasion, epithelial-mesenchymal transition, metastasis, and poor clinical outcome. IQGAP3 knockdown or inhibition commonly suppresses tumor-cell growth and invasive behavior in experimental models.
Scientific Papers found: Click to Expand⟱
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IQGAP3↓, 1,   O-Glc↓, 1,   SERPINH1/HSP47↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CTSB↓, 1,   CTSD↓, 1,   EMT↓, 1,   ERK↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   Rac1↓, 1,   Rho↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

RadioS↑, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IQGAP3, IQ Motif Containing GTPase Activating Protein 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1754  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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