PXR, NR1I2 Cancer Research Results

PXR, NR1I2, Nuclear Receptor Subfamily 1 Group I Member 2 / Pregnane X Receptor: Click to Expand ⟱
Source:
Type:

NR1I2 - Nuclear Receptor Subfamily 1 Group I Member 2 / Pregnane X Receptor

Abbreviation: PXR, NR1I2

Alternative Names: Pregnane X Receptor, Steroid and Xenobiotic Receptor (SXR)

Type: Ligand-activated nuclear receptor / transcription factor / xenobiotic sensor

Function: PXR is a ligand-activated nuclear receptor expressed predominantly in the liver and intestine. It heterodimerizes with RXR and regulates genes involved in xenobiotic metabolism, drug transport, bile-acid homeostasis, lipid metabolism, glucose metabolism, inflammation, and detoxification. Major downstream targets include CYP3A4 and multiple drug-transport proteins.

Cancer: ↕ Context-dependent. PXR activation can promote cancer-cell survival, proliferation, invasion, metastasis, and chemotherapy resistance by inducing drug-metabolizing enzymes and efflux transporters and by modulating apoptosis, oxidative stress, and inflammatory signaling. However, PXR can also exert protective or tumor-suppressive effects in selected tissues and disease contexts, so its cancer direction should be interpreted by tumor type and ligand.

Favorable Direction in Cancer: Context-dependent. In tumors where PXR promotes drug resistance or tumor progression, ↓ PXR activity is generally favorable.
Scientific Papers found: Click to Expand⟱
8190- LGE,  doxoR,    Cymbopogon citratus and Citral Overcome Doxorubicin Resistance in Cancer Cells via Modulating the Drug's Metabolism, Toxicity, and Multidrug Transporters
- in-vitro, BC, MCF7 - in-vitro, Liver, HepG2 - in-vitro, Ovarian, SKOV3
ChemoSen↑, CYP3A4↓, PXR, NR1I2↓, GSTA1↓, MDR1↓, MRP1/ABCC1↓, ABCG2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PXR, NR1I2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSTA1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   ChemoSen↑, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PXR, NR1I2, Nuclear Receptor Subfamily 1 Group I Member 2 / Pregnane X Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1776  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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