NHEJ Cancer Research Results

NHEJ, Non-Homologous End Joining: Click to Expand ⟱
Source:
Type:

NHEJ - Non-Homologous End Joining

Abbreviation: NHEJ, c-NHEJ

Type: DNA double-strand break repair pathway / DNA damage response process

Function: NHEJ repairs DNA double-strand breaks by directly recognizing, processing, and ligating broken DNA ends without requiring a homologous DNA template. It is a major double-strand break repair pathway in mammalian cells and is particularly active during G0/G1. Because DNA ends may require processing before ligation, NHEJ can introduce small insertions or deletions at the repaired junction.

Major Components: KU70/XRCC6, KU80/XRCC5, DNA-PKcs/PRKDC, Artemis/DCLRE1C, XRCC4, XLF/NHEJ1, PAXX, and DNA Ligase IV/LIG4.

Cancer: ↕ Context-dependent. Normal NHEJ protects genomic integrity by repairing potentially lethal DNA double-strand breaks. However, established cancer cells can exploit NHEJ to survive radiation, replication-associated damage, and DNA-damaging chemotherapy, contributing to treatment resistance.

Favorable Direction in Cancer: Context-dependent. ↓ NHEJ activity can be favorable during radiation or DNA-damaging therapy by preventing repair of treatment-induced double-strand breaks, whereas severe loss of NHEJ in normal cells can increase genomic instability and cancer risk.

Interpretation Note: Classical NHEJ should be distinguished from alternative end joining (alt-EJ/MMEJ/TMEJ), which uses different proteins and often relies on short regions of microhomology.
Scientific Papers found: Click to Expand⟱
8265- LE,    Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response
- vitro+vivo, CRC, NA
TumCG↓, Inflam↓, tumCV↓, DNAdam↑, Apoptosis↑, Casp3↑, TumCCA↑, cycD1/CCND1↓, HMGB1↓, NHEJ↓, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NHEJ↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   Inflam↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NHEJ, Non-Homologous End Joining
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1793  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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