MAPK Cancer Research Results

MAPK, mitogen-activated protein kinase: Click to Expand ⟱
Source: CGL-CS
Type:
Mitogen-activated protein kinases (MAPKs) are a group of proteins involved in transmitting signals from the cell surface to the nucleus, playing a crucial role in various cellular processes, including growth, differentiation, and apoptosis (programmed cell death).

MAPK Pathways: The MAPK family includes several pathways, the most notable being:
1.ERK (Extracellular signal-Regulated Kinase): Often associated with cell proliferation and survival.
2.JNK (c-Jun N-terminal Kinase): Typically involved in stress responses and apoptosis.
3.p38 MAPK: Associated with inflammatory responses and apoptosis.

Inhibitors: Targeting the MAPK pathway has become a strategy in cancer therapy. For example, BRAF inhibitors (like vemurafenib) are used in treating melanoma with BRAF mutations.
Altered Expression Levels:
Overexpression: Many cancers exhibit overexpression of MAPK pathway components, such as RAS, BRAF, and MEK. This overexpression can lead to increased signaling activity, promoting cell proliferation and survival.
Downregulation: In some cases, negative regulators of the MAPK pathway (e.g., MAPK phosphatases) may be downregulated, leading to enhanced MAPK signaling.
The expression levels of MAPK pathway components can serve as biomarkers for cancer diagnosis, prognosis, and treatment response. For example, high levels of phosphorylated ERK (p-ERK) may indicate active MAPK signaling and poor prognosis in certain cancers.

Numerous reports indicate that the MAPK pathway plays a major role in tumor progression and invasion, while inhibition of MAPK signaling reduces invasion.
Scientific Papers found: Click to Expand⟱
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
3450- ALA,    α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells
- in-vitro, GC, AGS
*IL8↓, *MAPK↓, *JAK↓, *STAT↓, *NF-kB↓,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
1242- BBM,    Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways
- in-vivo, Nor, NA
*Macrophages↓, *Neut↓, *p‑NF-kB↓, *p‑MAPK↓, *p‑JNK↓, *p‑ERK↓,
2690- BBR,    Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice
- in-vivo, Diabetic, NA
*Inflam↓, *Th17↓, *Th1 response↓, *ERK↑, *p38↓, *JNK↓, *STAT1↓, *STAT4↓, *MAPK↓,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
*Inflam↓, *antiOx↑, *Ca+2↓, *BioAv↓, *BioAv↑, *BioAv↑, *angioG↑, *MAPK↓, *AMPK↓, *NF-kB↓, VEGF↓, PI3K↓, Akt↓, MMP2↓, Bcl-2↓, ERK↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
2758- BetA,    Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
8973- BRice,    Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
- in-vitro, Nor, RAW264.7
*Ingr↝, *Inflam↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *NF-kB↓, *AP-1↓, *p‑ERK↓, *p‑p38↓, *p‑JNK↓, *MAPK↓,
1011- CA,    Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways
- in-vivo, Nor, NA
*iNOS↓, *IL6↓, *SOX9↑, *NF-kB↓, *MAPK↓, *Cartilage↑,
7832- CA,  CGA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *cognitive↑, *memory↑, *ROS↓, *p‑tau↓, *GSK‐3β↓, *MAPK↓, *NeuroI↓, *P53↓, *Casp3↓, *AChE↓, *APP↓, *BACE/β-secretase↓, *neuroP↑, *Dose↝,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6034- CGA,    Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *TNF-α↓, *antiOx↑, *Inflam↓, *neuroP↑, *BBB↑, *eff↑, *memory↑, *AKT1↓, *MMP9↓, *MAPK↓,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
6626- Cic,  Ech,    Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models
- in-vivo, Nor, NA
*antiOx↑, *Obesity↓, *memory↑, *Aβ↓, *MAPK↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *NF-kB↓,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, Synergy↑, ROS↑, Akt↑, Casp3↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
6984- Form,    Formononetin suppresses colitis-associated colon cancer by targeting lipid synthesis and mTORC2/Akt signaling
- in-vitro, Colon, HCT116 - Review, IBD, RAW264.7
*Inflam↓, AntiCan↑, *NF-kB↓, *MAPK↓, *colonLen↑, TumCG↓, Apoptosis↑, LC3II↑, Beclin-1/ATG6↑, cl‑Casp3↑, BAX↑, Bcl-2↓, IGF-1↓, ACLY↓, Acetyl-CoA↓, Fas↓, HSL/LIPE↓, ATGL/PNPLA2↓, FFA/NEFA↓, GSK‐3β↑, p‑mTOR↓, Rictor↓, p‑Akt↓, PDE3B↓, p‑PKA↓, p‑HSL/LIPE↑, TumAuto↑,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
7035- GA,    Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
- in-vitro, IBD, Caco-2
*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7862- isoO,    Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia
- in-vitro, Nor, BV2
*Apoptosis↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *TNF-α↓, *MAPK↓, *NF-kB↓, *ROS↓, *NeuroI↓,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
9231- ITCs,  Cisplatin,  AITC,  BITC,    Isothiocyanates inhibit the cisplatin-induced apoptosis and inflammation in human kidney HEK-293 cells
- in-vitro, Nor, HEK293
*ROS↓, *NO↓, *chemoP↑, *MAPK↓, *Bax:Bcl2↓, *Apoptosis↓, *RenoP↑,
7900- IVT,    Isovitexin: A Promising Active Compound Found in Nature's Bounty
- in-vivo, Nor, NA
*BioAv↓, *Imm↝, *antiOx↑, *AntiCan↑, *neuroP↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *MAPK↓, *MPO↓, *ROS↓, TumAuto↑, Apoptosis↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
8073- KAE,    Kaempferol inhibits oxidative stress-induced ferroptosis via the ROS/P38MAPK pathway to delay intervertebral disc degeneration: a combinatorial study of cell, animal, and transcriptomic evidence
- Review, Nor, NA
*Inflam↓, *antiOx↑, *ROS↓, *MAPK↓, *Ferroptosis↓,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
8230- LCA,    The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway
- vitro+vivo, Nor, NA
*hepatoP↑, *ROS↓, *TLR4↓, *NF-kB↓, *MAPK↓, *NLRP3↓, *NRF2↑, *Inflam↓, *Pyro↓,
8284- LE,    Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation
- in-vivo, Nor, NA
*Ingr↝, *iNOS↓, *COX2/PTGS2↓, *IκB↓, *p65↓, *ERK↓, *p38↓, *MAPK↓, *PI3K↓, *Akt↓, *NF-kB↓,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,

Showing Research Papers: 1 to 50 of 74
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 74

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   Iron↝, 1,   MPO↓, 1,   ROS↓, 2,   ROS↑, 9,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   mtDam↑, 1,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   ACLY↓, 1,   adiP↑, 1,   AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 2,   FASN↓, 1,   FFA/NEFA↓, 1,   glyC↓, 1,   Glycolysis↓, 3,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   HK2↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   NADPH↓, 2,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 11,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   BNIP3↝, 1,   Casp↑, 2,   Casp3↑, 6,   cl‑Casp3↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Fas↓, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 2,   TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 1,   p‑Akt↓, 2,   CK2↓, 2,   cMET↓, 1,   EGFR↓, 1,   ERK↓, 3,   HER2/EBBR2↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 2,   mTOR↓, 4,   p‑mTOR↓, 2,   P70S6K↓, 1,   PDE3B↓, 1,   PI3K↓, 6,   p‑PI3K↓, 1,   p‑PKA↓, 1,   Rictor↓, 1,   STAT↓, 1,   STAT3↓, 4,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   DNMT1↓, 1,   HDAC↓, 1,   miR-34a↑, 1,   MYCN↓, 1,   OCT4↓, 1,   SOX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3II↑, 2,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 3,   CDKN1C/p57↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 4,   Ki-67↓, 1,   P21↑, 3,   p‑pRB↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1,   CSCs↓, 1,   IGF-1↓, 3,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 1,   Nanog↓, 1,   TumCG↓, 3,   TumCP↓, 7,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   AP-1↑, 1,   Ca+2↑, 3,   cal2↑, 1,   Cofilin↓, 1,   E-cadherin↑, 5,   EMT↓, 1,   FAK↓, 1,   fascin↓, 1,   ITGB4↓, 1,   LIMK2↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 4,   N-cadherin↓, 1,   ROCK1↓, 1,   TGF-β↓, 2,   TIMP2↑, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumMeta↓, 4,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 3,   VEGF↓, 6,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT4↓, 1,   MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 3,   HMGB1↓, 1,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 2,   M2 MC↓, 1,   NF-kB↓, 4,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   ChemoSen↑, 7,   Dose↝, 3,   eff↑, 3,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   chemoP↑, 1,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↑, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 3,   Risk↓, 1,   toxicity↓, 1,   TumVol↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 197

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 29,   ARE↑, 2,   Bil↑, 1,   Catalase↑, 14,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 11,   GPx4↑, 1,   GSH↑, 15,   GSR↓, 1,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1↓, 1,   HO-1↑, 24,   hyperG↝, 1,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 11,   MDA↓, 17,   MPO↓, 4,   NQO1↑, 5,   NRF2↓, 3,   NRF2↑, 29,   RNS↓, 1,   ROS↓, 48,   ROS↑, 1,   SOD↑, 23,   SOD1↑, 2,   TAC↑, 5,   TBARS↓, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   MFN2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 8,   ATP↑, 2,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 1,   glucose↝, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HMG-CoA↓, 1,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 1,   SCFAs↑, 1,   SIRT1↑, 3,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 12,   BAD↓, 1,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 2,   Casp3↓, 10,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 4,   Casp9∅, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 3,   iNOS↓, 16,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 7,   p‑p38↓, 4,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 10,   AKT1↓, 1,   CREB↑, 1,   EGFR↓, 2,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 5,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 6,   p‑JNK↓, 5,   LPAR1/EDG2↑, 1,   MAPK↓, 71,   p‑MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PI3K↓, 8,   PI3K↑, 6,   PKA↑, 1,   PKCδ↓, 2,   PTEN↓, 2,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   Src↓, 1,   STAT↓, 2,   STAT3↓, 4,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   FOXO3↑, 1,   other↑, 2,   other↝, 3,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 2,   PARP↓, 1,   PARP∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   HH↓, 1,   IGF-1↑, 1,   neuroG↑, 2,   STAT1↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 4,   ARG1/2↑, 1,   Ca+2↓, 3,   Cartilage↑, 3,   COL1↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   MMP2↓, 1,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 1,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   NO↓, 11,   VCAM-1↓, 5,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 9,   CLDN1↓, 1,   GLUT2↑, 1,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 2,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   OCLN↓, 1,   TJ↑, 2,   TRPV1↑, 1,   ZO-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 19,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↑, 6,   IL12↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 1,   IL6↓, 23,   IL6↑, 1,   IL8↓, 3,   Imm↝, 1,   Inflam↓, 46,   Inflam↑, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 2,   Neut↓, 1,   NF-kB↓, 48,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NLRP3↓, 12,   p65↓, 1,   p‑p65↓, 1,   PAF↓, 1,   PGE1↓, 1,   PGE2↓, 9,   RAGE↓, 1,   Th1 response↓, 1,   Th17↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 29,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 3,   Ach↑, 2,   AChE↓, 8,   BChE↓, 2,   BDNF↑, 5,   BDNF∅, 1,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 1,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 2,   Aβ↓, 11,   Aβ42↓, 2,   BACE/β-secretase↓, 3,   BACE/β-secretase↑, 1,   tau↓, 3,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   GLP-1R↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 16,   BioAv↝, 6,   ChemoSen↑, 1,   Dose⇅, 1,   Dose↝, 5,   eff↑, 4,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   anemia↓, 1,   AST↓, 2,   Bil↑, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BUN↓, 1,   CEA↓, 1,   colonLen↑, 1,   CRP↓, 3,   EGFR↓, 2,   Ferritin↓, 1,   HemoG↑, 1,   IL6↓, 23,   IL6↑, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 3,   NOS2↓, 1,   RAGE↓, 1,   RBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiCan↑, 5,   antiCG↑, 1,   AntiDiabetic↑, 4,   cardioP↑, 10,   chemoP↑, 3,   cognitive↑, 14,   diuretic↑, 1,   hepatoP↑, 11,   memory↑, 13,   motorD↑, 2,   neuroP↑, 31,   Obesity↓, 4,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 7,   Risk↓, 1,   Strength↑, 2,   Stroke↓, 4,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 3,   Bacteria↓, 6,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 332

Scientific Paper Hit Count for: MAPK, mitogen-activated protein kinase
4 Chlorogenic acid
3 Berberine
3 Gallic acid
3 Isovitexin
3 Quercetin
3 Silymarin (Milk Thistle) silibinin
2 Apigenin (mainly Parsley)
2 Baicalein
2 Cisplatin
2 Betulinic acid
2 Caffeic acid
2 Cichoric acid / Chicoric acid
2 Echinacea
2 isoorientin
2 Kaempferol
2 Licochalcone A
2 Lactoferrin/Talactoferrin
2 Lycopene
2 Propolis -bee glue
2 Urolithin
1 1,8-Cineole
1 Alpha-Lipoic-Acid
1 Berbamine
1 Beta-Caryophyllene
1 Black Rice, Oryza sativa
1 Mung Bean Sprouts
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Chrysin
1 diet FMD Fasting Mimicking Diet
1 Ferulic acid
1 Formononetin
1 Fucoidan
1 Ginkgo biloba
1 Ginkgolide B
1 Ginkgetin
1 Ginseng
1 Isoliquiritigenin
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 L-Theanine
1 Licorice
1 Luteolin
1 Magnolol
1 Magnetic Field Rotating
1 Magnetic Fields
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Piperine
1 Pterostilbene
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 Sulforaphane (mainly Broccoli)
1 Terminalia bellirica
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 5-fluorouracil
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:181  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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