TPH1 Cancer Research Results

TPH1, Tryptophan Hydroxylase 1: Click to Expand ⟱
Source:
Type:

TPH1 - Tryptophan Hydroxylase 1

Abbreviation: TPH1, TPH-1

Type: Enzyme / serotonin biosynthesis enzyme / aromatic amino acid hydroxylase

Function: TPH1 catalyzes the rate-limiting step in peripheral serotonin (5-HT) synthesis by converting tryptophan to 5-hydroxytryptophan (5-HTP), which is subsequently converted to serotonin. TPH1 is expressed primarily in peripheral tissues, including enterochromaffin and other serotonin-producing cells.

Inflammatory Bowel Disease: ↑ TPH1 activity and peripheral serotonin production can promote intestinal inflammation. Increased 5-HT signaling has been associated with greater severity of experimental colitis.

Favorable Direction in Intestinal Inflammation: ↓ TPH1 expression or activity can reduce peripheral 5-HT production and intestinal inflammatory signaling.

Luteolin: ↓ TPH1 gene and protein expression, accompanied by ↓ MAPK/ERK signaling and ↓ 5-HT production in stimulated cells; luteolin also reduced elevated colorectal 5-HT in experimental colitis.

Pathway Relationship: Tryptophan → TPH1 → 5-HTP → 5-HT. TPH1 ↓ → serotonin synthesis ↓ → intestinal inflammatory signaling ↓.

Interpretation Note: TPH1 should be distinguished from TPH2. TPH1 primarily regulates peripheral serotonin synthesis, whereas TPH2 is predominantly responsible for neuronal serotonin synthesis in the central nervous system.
Scientific Papers found: Click to Expand⟱
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑mTOR↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

TPH1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   ERK↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: TPH1, Tryptophan Hydroxylase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1823  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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