PCO Cancer Research Results

PCO, Protein Carbonyl: Click to Expand ⟱
Source:
Type:

Protein Carbonyl - Protein Carbonylation

Abbreviation: PCO, Protein Carbonyls

Type: Oxidative stress biomarker / oxidative protein damage marker / irreversible post-translational modification

Function: Protein carbonylation is an irreversible oxidative modification in which carbonyl groups are introduced into proteins through direct oxidation of amino-acid residues or indirectly through reactions with lipid-peroxidation, glycation, or other reactive carbonyl products. Protein carbonyl content is widely used as a relatively stable biomarker of oxidative protein damage.

Oxidative Stress: ↑ Protein carbonyl levels indicate increased oxidative modification and damage to proteins and can be associated with altered protein structure, loss of enzyme or receptor function, protein aggregation, and cellular dysfunction.

Favorable Direction: ↓ Protein carbonyl levels are generally favorable and indicate reduced oxidative protein damage.

Cancer: ↕ Context-dependent. Chronically ↑ protein carbonylation can contribute to oxidative damage, proteotoxic stress, genomic instability, and carcinogenesis. However, an anticancer treatment that deliberately induces oxidative stress may cause ↑ protein carbonylation within tumor cells as part of a cytotoxic mechanism.

Alzheimer's Disease: ↑ Protein carbonylation is associated with increased oxidative protein damage in Alzheimer's disease and other neurodegenerative disorders and can contribute to loss of protein function and protein aggregation.

Favorable Direction in Alzheimer's Disease: ↓ Protein carbonylation is generally favorable and indicates reduced oxidative protein damage.

Measurement: Protein carbonyls are commonly measured after derivatization with 2,4-dinitrophenylhydrazine (DNPH), followed by spectrophotometry, ELISA, immunoblotting, or related analytical methods.
Scientific Papers found: Click to Expand⟱
8470- Mg,  Z,    The Effects of Magnesium and Zinc Co-Supplementation on Biomarkers of Inflammation and Oxidative Stress, and Gene Expression Related to Inflammation in Polycystic Ovary Syndrome: a Randomized Controlled Clinical Trial
- Trial, Nor, NA
*Dose?, *CRP↓, *PCO↓, *TAC↑, *IL1↓, *TNF-α↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PCO↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

TAC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL1↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,  
Total Targets: 7

Scientific Paper Hit Count for: PCO, Protein Carbonyl
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1841  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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