MMPs Cancer Research Results

MMPs, Matrix metalloproteinases: Click to Expand ⟱
Source:
Type:
Family of zinc-dependent proteolytic enzymes that play a key role in degrading the extracellular matrix (ECM).; are metalloproteinases that are calcium-dependent zinc-containing endopeptidases;[1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.[2]
MMP secretion: matrix metalloproteinase (MMP) is a kind of enzymes secreted.
by tumor cell to degrade ECM, facilitating the migration of tumor cells.

MMPs are generally considered protumorigenic due to their role in promoting tumor invasion, metastasis, and angiogenesis. They facilitate the breakdown of the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant sites.
Scientific Papers found: Click to Expand⟱
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *Synergy↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
1239- PACs,    Cranberry proanthocyanidins inhibit MMP production and activity
- in-vitro, Nor, NA
*MMPs↓, *MMP1↓, *MMP9↓, *NF-kB↓,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2/PTGS2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1/CCL2↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
3129- VitC,    Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis
- in-vivo, Stroke, NA
*BBB↑, *MMP9↓, *MMPs↓, *MMP2↓, *CLDN1↝, *ZO-1↝, eff↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 5,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 2,   Prx↑, 1,   ROS↓, 5,   SOD↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   LDL↓, 2,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1,   MAPK↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 9,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↝, 1,   MMP↑, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 6,   IL1β↓, 3,   IL2↓, 1,   IL4↓, 1,   IL8↓, 1,   Inflam↓, 3,   MCP1/CCL2↓, 1,   NF-kB↓, 6,   PGE2↓, 3,   RAGE↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF∅, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 4,   BioEnh↑, 1,   CYP3A2↓, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 2,   memory↑, 3,   neuroP↑, 2,   toxicity↓, 2,   Weight↓, 1,  
Total Targets: 66

Scientific Paper Hit Count for: MMPs, Matrix metalloproteinases
1 Cichoric acid / Chicoric acid
1 Echinacea
1 Curcumin
1 Lycopene
1 Proanthocyanidins
1 Piperine
1 Pterostilbene
1 Rosmarinic acid
1 Thymoquinone
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:204  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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