NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1/CCL2↓, *NF-kB↓, IKKα↓,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3450- ALA,    α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells
- in-vitro, GC, AGS
*IL8↓, *MAPK↓, *JAK↓, *STAT↓, *NF-kB↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
272- ALA,    Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function
- in-vitro, Nor, HUVECs
*NF-kB↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, CompStab↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
3392- ART/DHA,    Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways
- in-vitro, Nor, Hep3B - in-vivo, NA, NA
*Inflam↓, *NF-kB↓, *ROS↓, *p‑p38↓, *p‑ERK↓,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- in-vivo, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *cognitive↑,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
5793- ASA,    Aspirin Recapitulates Features of Caloric Restriction
- in-vitro, Nor, NA
*CRM↑, *HATs↓, *NF-kB↓, *EP300↓,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
3689- Ash,    Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells
- in-vitro, Nor, NRK52E
*RenoP↑, *NF-kB↓, *MCP1/CCL2↓, *RANTES↓,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1/CCL2↓, *hepatoP↑, *neuroP↑, *antiAll↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
1242- BBM,    Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways
- in-vivo, Nor, NA
*Macrophages↓, *Neut↓, *p‑NF-kB↓, *p‑MAPK↓, *p‑JNK↓, *p‑ERK↓,
2670- BBR,    Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases
- Review, Var, NA
*Inflam↓, *antiOx↑, *Ca+2↓, *BioAv↓, *BioAv↑, *BioAv↑, *angioG↑, *MAPK↓, *AMPK↓, *NF-kB↓, VEGF↓, PI3K↓, Akt↓, MMP2↓, Bcl-2↓, ERK↓,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,

Showing Research Papers: 1 to 50 of 378
Page 1 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 378

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 3,   Catalase↑, 3,   Fenton↑, 1,   GPx↑, 1,   GSH↓, 8,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 3,   HO-1↑, 3,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 2,   ROS↓, 9,   ROS↑, 42,   mt-ROS↑, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD1↑, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OCR↑, 1,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 4,   ECAR↓, 1,   FFA/NEFA↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 7,   GSK‐3β↓, 1,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 3,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 2,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 45,   ASC↑, 1,   BAD↑, 2,   Bak↑, 2,   BAX↑, 17,   BAX⇅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 5,   Bcl-2↓, 23,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↑, 2,   BNIP3↑, 1,   Casp↑, 3,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp12↑, 1,   Casp3↑, 25,   cl‑Casp3↑, 5,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 7,   proCasp8↑, 1,   Casp9↑, 14,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 10,   mt-Cyt‑c↓, 1,   DR5↑, 2,   FADD↑, 1,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 3,   FasL↑, 2,   IAP1↓, 4,   iNOS↓, 3,   Mcl-1↓, 4,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 1,   necrosis↑, 1,   p38↓, 2,   p38↑, 5,   Pyro↑, 2,   survivin↓, 9,   TumCD↑, 3,   XIAP↓, 5,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 35,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 5,   Akt2↓, 1,   CIP2A↓, 1,   p‑cMET↑, 1,   EGFR↓, 7,   ERK↓, 10,   ERK↑, 3,   p‑ERK↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IKKα↓, 2,   JAK↓, 2,   JAK2↓, 2,   JNK↓, 3,   JNK↑, 3,   MAPK↓, 9,   MAPK↑, 3,   MAPK↝, 1,   MARK4↓, 1,   mTOR↓, 19,   mTOR↝, 1,   p‑mTOR↓, 1,   P70S6K↓, 2,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 32,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 2,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 3,   Src↓, 1,   STAT↓, 3,   STAT3↓, 18,   STAT3↑, 1,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cMyc↓, 5,   DNMTs↓, 2,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO4↓, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC8↓, 2,   HES1↓, 1,   miR-200b↑, 1,   miR-34a↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↓, 2,   other↑, 1,   other↝, 1,   PAX2↓, 1,   SOX2↓, 2,   tumCV?, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 4,   HSPs↓, 1,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3B↑, 1,   LC3II↑, 5,   p62↓, 2,   p62↑, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 7,   hTERT/TERT↓, 2,   P53↓, 3,   P53↑, 18,   P53↝, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↑, 8,   PCNA↓, 10,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 9,   CDK2↑, 1,   CDK4↓, 12,   CDK6↓, 3,   CDKN1C/p57↑, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 20,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 4,   Ki-67↓, 7,   mitA↑, 1,   P21↓, 1,   P21↑, 12,   p27/CDKN1B↑, 2,   pRB↓, 1,   p‑RB1↓, 1,   TumCCA↑, 41,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 1,   CSCs↓, 2,   EIF4E↓, 1,   IGF-1?, 1,   IGF-1↓, 3,   IGF-2↓, 1,   Ki-67↓, 7,   Let-7↑, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 3,   NOTCH↑, 1,   NOTCH1↓, 2,   NOTCH1↑, 1,   NOTCH3↓, 1,   SCF↓, 1,   Shh↓, 1,   TumCG↓, 13,   TumCG↑, 1,   TumCP↓, 25,   Wnt↓, 9,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 5,   EMT↓, 15,   EMT↝, 1,   FAK↓, 2,   FAK↑, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   LAMs↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 23,   MMP7↓, 2,   MMP9↓, 26,   MMP9↑, 1,   MMPs↓, 8,   N-cadherin↓, 3,   PDGF↓, 1,   Rho↑, 1,   ROCK1↑, 1,   serineP↓, 1,   Slug?, 1,   Slug↓, 2,   Snail?, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 2,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 11,   TumCMig↓, 17,   TumMeta↓, 12,   TumMeta↑, 4,   Twist↓, 4,   uPA↓, 1,   Vim↓, 3,   Zeb1↓, 1,   Zeb1↑, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   Hif1a↓, 13,   Hif1a↝, 1,   LOX1↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 30,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 2,   EPR↑, 1,   GLUT4↓, 1,   MMP↓, 15,   MMP↑, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   COX2/PTGS2↑, 3,   CXCc↓, 1,   CXCL16↓, 1,   CXCR4↓, 3,   CXCR4↑, 1,   DR4↑, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IL10↓, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 5,   IL6↓, 7,   IL6↑, 1,   IL8↓, 2,   Imm↑, 1,   Imm↝, 2,   Inflam↓, 6,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 16,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 3,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 7,   PSA↓, 3,   T-Cell↑, 1,   TLR4↓, 5,   TLR4↝, 1,   TNF-α↓, 7,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   CYP17A1↓, 1,   CYP19↓, 1,   ER-α36↓, 1,   ER(estro)↑, 1,   PPARα↓, 2,   PPARγ↓, 2,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 12,   BioAv↝, 5,   BioEnh↑, 1,   ChemoSen↑, 34,   CompStab↓, 1,   CompStab↑, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   Dose↑, 2,   Dose↝, 6,   eff↓, 1,   eff↑, 13,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 4,   RadioS↑, 3,   selectivity↑, 14,   selectivity∅, 1,   Synergy↑, 22,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 3,   ascitic↓, 1,   CA19-9↓, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 7,   FOXM1↓, 2,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 7,   IL6↑, 1,   LDH↓, 2,   Myc↓, 1,   PD-L1↓, 2,   PSA↓, 3,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 16,   AntiTum↑, 8,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 9,   chemoPv↑, 9,   cognitive?, 1,   cognitive↑, 3,   hepatoP↑, 2,   neuroP↑, 5,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 4,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 5,   Risk↓, 4,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 6,   TumW↓, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 484

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 4,   antiOx↑, 152,   ARE↑, 6,   ARE↝, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 76,   DPPH↓, 1,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 46,   GPx4↑, 1,   GSH↑, 92,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 10,   GSSG↓, 3,   GSTs↓, 2,   GSTs↑, 17,   H2O2↓, 6,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 4,   HNE↓, 1,   HNE↑, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 89,   hyperG↓, 1,   Iron↓, 1,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 73,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 76,   MDA↑, 1,   MPO↓, 19,   NFE2L2↓, 1,   NOX↓, 3,   NOX4↓, 5,   NQO1↑, 15,   Nrf1↑, 5,   NRF2?, 1,   NRF2↓, 5,   NRF2↑, 139,   NRF2↝, 1,   ONOO↓, 1,   Prx↑, 1,   RNS↓, 4,   ROS?, 2,   ROS↓, 241,   ROS↑, 3,   ROS⇅, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 2,   SOD↓, 1,   SOD↑, 108,   SOD1↑, 5,   SOD2↑, 3,   TAC↑, 16,   TBARS↓, 6,   Thiols↑, 2,   TOS↓, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 1,   UCPs↑, 1,   uricA↓, 2,   VitC↑, 3,   VitE↓, 1,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 11,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 3,   mtDam↓, 5,   OCR↓, 1,   PGC-1α↓, 3,   PGC-1α↑, 7,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 9,   ACC↓, 2,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 31,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 26,   AMPK⇅, 1,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 10,   Buty↑, 1,   cAMP↑, 3,   CPT1A↑, 1,   CRM↑, 2,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 2,   glucose↓, 5,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 3,   GlutMet↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 21,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HMG-CoA↓, 1,   LDL↓, 11,   lipidLev↓, 2,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 10,   NADPH↑, 7,   PGC1A↑, 1,   PKM2↓, 2,   PLA2↓, 1,   SCD1↓, 1,   SCFAs↑, 2,   SIRT1↑, 24,   SIRT1↝, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 32,   Apoptosis↑, 1,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 20,   BAX↑, 3,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 14,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   Casp↓, 2,   Casp1↓, 5,   Casp12↓, 1,   Casp3↓, 33,   Casp3↑, 1,   Casp3∅, 2,   cl‑Casp3↓, 3,   Casp6↓, 1,   Casp8↓, 2,   Casp9↓, 11,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 7,   Cyt‑c↑, 1,   Cyt‑c∅, 3,   Fas↓, 2,   Ferroptosis↓, 3,   GSDMD↓, 1,   iNOS↓, 73,   iNOS↑, 3,   necrosis↓, 2,   p38↓, 11,   p38↑, 3,   p‑p38↓, 8,   Pyro?, 1,   Pyro↓, 2,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 13,   Akt↑, 17,   Akt↝, 2,   p‑Akt↓, 2,   p‑Akt↑, 7,   Akt2↓, 1,   CREB↓, 1,   CREB↑, 4,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 17,   ERK↑, 6,   p‑ERK↓, 6,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB↓, 2,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 17,   JNK↑, 1,   p‑JNK↓, 8,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 44,   MAPK↑, 7,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 3,   p‑MKK4↑, 1,   mTOR↓, 3,   mTOR↑, 2,   mTOR↝, 2,   p‑mTOR↓, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 13,   PI3K↑, 12,   PI3K↝, 1,   PKA↑, 2,   PKCδ↓, 1,   PKCδ↑, 3,   PP2A↑, 1,   PTEN↓, 3,   PTEN↑, 2,   STAT↓, 4,   STAT3↓, 9,   STAT3↑, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 2,   HATs↓, 2,   HDAC↓, 3,   HDAC↑, 1,   HDAC2↓, 2,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 6,   other↑, 5,   other↝, 11,   RUNX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 1,   ER Stress↓, 6,   GRP78/BiP↓, 5,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   HSPs↝, 1,   PERK↓, 1,   UPR↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 3,   LC3B↑, 1,   LC3II↓, 2,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 2,   p62↑, 4,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   P53↓, 5,   P53↝, 1,   PARP↓, 1,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 2,   EP300↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   MSCs↑, 1,   neuroG↑, 3,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 16,   AP-1↓, 12,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 5,   COL1↓, 2,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 1,   MMP9↓, 16,   MMP9↑, 2,   MMPs↓, 5,   MMPs↑, 2,   MUC1↑, 2,   Na+↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 3,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 10,   TGF-β↑, 4,   TGF-β1↓, 2,   TGF-β1↑, 2,   TIMP1↓, 2,   TIMP1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   α-SMA↓, 5,   α-SMA↝, 1,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 3,   angioG↝, 1,   E-sel↓, 5,   ECM/TCF↑, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 5,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 50,   NO↑, 3,   TXA2↓, 1,   VCAM-1↓, 18,   VEGF↓, 8,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 1,   BBB↑, 32,   BBB↝, 4,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN3↑, 1,   CLDN4↑, 1,   GastroP↑, 5,   GLUT1↑, 2,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 5,   MMP↓, 2,   MMP↑, 22,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 4,   OCLN↝, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 7,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 3,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 111,   COX2/PTGS2↑, 2,   CXCR2↓, 1,   CXCR3↓, 1,   FOXP3↑, 2,   HMGB1↓, 7,   ICAM-1↓, 17,   IFN-γ↓, 14,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 9,   IL10↓, 7,   IL10↑, 26,   IL12↓, 6,   IL13↓, 1,   IL17↓, 7,   IL18↓, 3,   IL1RL1/ST2↓, 1,   IL1β↓, 104,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL23↓, 4,   IL33↓, 2,   IL4↓, 9,   IL4↑, 6,   IL5↓, 3,   IL5↑, 1,   IL6↓, 117,   IL6↑, 1,   IL8↓, 25,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 9,   Imm⇅, 1,   Imm↝, 1,   INF-γ↓, 1,   INF-γ↑, 1,   Inflam?, 1,   Inflam↓, 242,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 4,   LPS↓, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M2 MC↑, 1,   pol-M2 MC↑, 2,   Macrophages↓, 1,   MCP1/CCL2↓, 15,   MCP1/CCL2↑, 1,   MCT1↓, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 10,   NeuroI↓, 10,   Neut↓, 1,   NF-kB↓, 377,   NF-kB↑, 1,   p‑NF-kB↓, 10,   NK cell↑, 2,   NLRP3↓, 40,   NLRP3↑, 2,   p‑p50↓, 1,   p65↓, 8,   p‑p65↓, 3,   PAF↓, 1,   PGE1↓, 1,   PGE2↓, 39,   PGE2↑, 1,   RAGE↓, 6,   RANTES↓, 3,   SOCS-3↓, 1,   Th2↓, 1,   TLR1↓, 2,   TLR2↓, 7,   TLR3↓, 1,   TLR4↓, 34,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 170,   TNF-α↑, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   GGT/CD224↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↑, 3,   Ach↑, 7,   AChE↓, 36,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 9,   BDNF↓, 3,   BDNF↑, 35,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 5,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 3,   MAOA↝, 1,   MAOB↓, 1,   NGF↑, 5,   PSD95?, 1,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN1↑, 1,   SYT1↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 5,   Aβ↓, 55,   Aβ42↓, 4,   BACE/β-secretase↓, 20,   BACE/β-secretase↑, 1,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 21,   XO↓, 2,   β-Amyloid↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   AR↓, 1,   CYP19↓, 1,   END↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 4,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 18,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 37,   BioAv↑, 47,   BioAv⇅, 1,   BioAv↝, 30,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↓, 1,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 37,   eff↓, 3,   eff↑, 24,   eff↝, 1,   GSTA1↑, 4,   Half-Life↓, 2,   Half-Life↑, 3,   Half-Life↝, 9,   MRP↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 2,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 26,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 31,   ALB↝, 1,   ALP↓, 4,   AR↓, 1,   AST↓, 37,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 4,   BMD↑, 7,   BP↓, 11,   BP↝, 2,   BUN?, 1,   BUN↓, 4,   Calcium↑, 1,   CK/CK-MB↓, 1,   colonLen↑, 1,   creat↓, 9,   CRP↓, 7,   EGFR↓, 1,   HbA1c↓, 1,   hs-CRP↓, 1,   IL6↓, 117,   IL6↑, 1,   IRes↑, 1,   LDH↓, 12,   Mag↑, 1,   NOS2↓, 3,   RAGE↓, 6,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 3,   Urea↓, 2,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 2,   AntiAge↑, 4,   antiAll?, 1,   antiAll↑, 20,   AntiArt↑, 10,   AntiCan↑, 19,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 19,   AntiMyl↑, 1,   antiPs↑, 3,   AntiTum↑, 4,   cardioP?, 1,   cardioP↑, 64,   chemoP↑, 11,   chemoPv↑, 2,   cognitive↑, 69,   cognitive↝, 1,   cough?, 1,   diuretic↑, 3,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 65,   Learn↑, 5,   memory↑, 72,   Mood↑, 2,   motorD↑, 10,   neuroP↑, 139,   NP/CIPN↓, 2,   Obesity↓, 15,   OS↑, 5,   Pain↓, 5,   QoL↑, 1,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 22,   Risk↓, 4,   Sleep↑, 3,   SoreThr?, 1,   Strength↑, 3,   Stress↓, 2,   Stroke↓, 10,   toxicity↓, 19,   toxicity↑, 2,   toxicity↝, 10,   toxicity∅, 7,   Weight↓, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7,   AntiFungal↑, 5,   AntiP↑, 2,   AntiViral↑, 10,   Bacteria↓, 20,   Diar↓, 1,   Dysb↓, 1,   GutMicro↑, 27,   Inf↓, 1,   Sepsis↓, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 684

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
19 Curcumin
16 Thymoquinone
13 Quercetin
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Lycopene
11 Hydrogen Gas
9 Resveratrol
8 Baicalein
8 isoorientin
7 Propolis -bee glue
6 Beta-Caryophyllene
6 Chlorogenic acid
6 Chrysin
6 Emodin
6 Luteolin
6 Magnetic Fields
6 Rosmarinic acid
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Kaempferol
5 Licochalcone A
5 Magnolol
5 Matrine
5 Morin
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Cisplatin
4 Berberine
4 Radiotherapy/Radiation
4 Ferulic acid
4 Isovitexin
4 L-Theanine
4 Rutin
4 Shikonin
3 1,8-Cineole
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Boswellia (frankincense)
3 Caffeic acid
3 Cichoric acid / Chicoric acid
3 Crocetin
3 Cucurbitacin
3 Dandelion Root
3 Fisetin
3 Gallic acid
3 Ginger/6-Shogaol/Gingerol
3 Honokiol
3 Isoliquiritigenin
3 Licorice
3 Vitamin K2
2 Selenite (Sodium)
2 Apigenin (mainly Parsley)
2 Baicalin
2 Betulinic acid
2 Bacopa monnieri
2 borneol
2 Carnosic acid
2 Capsaicin
2 Carvacrol
2 Echinacea
2 Cinnamon
2 eicosapentaenoic acid
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Formononetin
2 Ginseng
2 Orlistat
2 Hyperoside
2 doxorubicin
2 Lemon Balm/Melissa officinalis
2 5-fluorouracil
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Piperine
2 Selenium NanoParticles
2 Urolithin
1 Anthocyanins
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Aspirin
1 Aloe anthraquinones
1 beta-glucans
1 Berbamine
1 Biochanin A
1 xanthohumol
1 Cannabidiol
1 Benzyl isothiocyanate
1 Selenium
1 Black Rice, Oryza sativa
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Castalagin
1 Cat’s Claw
1 Chlorophyllin
1 Chocolate
1 Carvone
1 Galantamine
1 Lecithin
1 Chemotherapy
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Docosahexaenoic Acid
1 Eugenol
1 methotrexate
1 Ascorbyl Palmitate
1 flavonoids
1 Flaxseed/Linseed
1 Fucoidan
1 Gambogic Acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgolide B
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 Juglone
1 lambertianic acid
1 SDG/lignans
1 Linalool
1 Lutein
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Field Rotating
1 Melatonin
1 Nimbolide
1 Proanthocyanidins
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Purple Corn / Purple Maize
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Parthenolide
1 Pterostilbene
1 Sesame seeds and Oil
1 Taurine
1 Terminalia bellirica
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 probiotics
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:214  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page