PGE2 Cancer Research Results

PGE2, Prostaglandin E2: Click to Expand ⟱

Source:

Type:

Prostaglandin E2 (PGE2) is a lipid compound that plays a significant role in various physiological processes, including inflammation, immune response, and regulation of cell growth. PGE2 is often found at elevated levels in various types of cancer, including colorectal, breast, and lung cancers. It can promote tumor growth by enhancing cell proliferation, inhibiting apoptosis (programmed cell death), and promoting angiogenesis (the formation of new blood vessels).
- PGE2 is a pain-inducing factor. It is able to sensitize primary sensory neurons and leads to central sensitization and also facilitate the release of pain-related neuropeptides
-Upregulated in AD brain; promotes inflammatory cytokine release, increase ROS, may increase Aβ deposition

Scientific Papers found: Click to Expand⟱

6461-

1,8-Cin,

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

Review,

AD,

Review,

Var,

*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,

6462-

1,8-Cin,

Modes of Action of 1,8-Cineol in Infections and Inflammation

Review,

Var,

Review,

AD,

*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,

2660-

AL,

Allicin: A review of its important pharmacological activities

Review,

AD,

Review,

Var,

Review,

Park,

Review,

Stroke,

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,

7146-

AL,

GI,

Eug,

CAP,

Herbal remedies and anticoagulant therapy

Review,

Nor,

*AntiAg↑, *PGE2↓, *AntiAg↑, *TXA2↓, *AntiAg↑,

3550-

ALA,

Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

Review,

AD,

*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,

4280-

Api,

Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms

Review,

AD,

Review,

Park,

*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,

5419-

ASTX,

Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications

Review,

Nor,

*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,

2605-

Ba,

BA,

Potential therapeutic effects of baicalin and baicalein

Review,

Var,

Review,

Stroke,

Review,

IBD,

Review,

Arthritis,

Review,

AD,

Review,

Park,

cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,

2626-

Ba,

Molecular targets and therapeutic potential of baicalein: a review

Review,

Var,

Review,

AD,

Review,

Stroke,

AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,

5631-

BCA,

Perspectives Regarding the Role of Biochanin A in Humans

Review,

Var,

Review,

AD,

*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,

2749-

BetA,

Anti-Inflammatory Activities of Betulinic Acid: A Review

Review,

Nor,

Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,

3518-

Bor,

Boron Report

Review,

Var,

Review,

AD,

Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2/PTGS2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,

2776-

Bos,

Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities

Review,

Var,

*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,

2772-

Bos,

Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties

Review,

AD,

*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,

5847-

CAP,

An updated review on molecular mechanisms underlying the anticancer effects of capsaicin

in-vitro,

Liver,

HepG2

HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,

5932-

CAR,

Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome

in-vivo,

IBD,

Male C57BL/6 J mice

in-vivo,

Park,

*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,

5943-

Cela,

Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

Review,

Arthritis,

Review,

IBD,

Review,

AD,

Review,

Park,

*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,

6018-

CGA,

Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems

Review,

Var,

Review,

RCC,

*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,

3583-

CUR,

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

Review,

Arthritis,

*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *Synergy↑,

1792-

CUR,

LEC,

Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism

in-vitro,

Arthritis,

RAW264.7

0.5-20 μM as curcumin) and LPS (1 μg/mL) for 48 h.

NA,

HCC-38

*Inflam↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *PGE2↓, *MMPs↑, *TIMP1↑, *BioEnh↑,

1418-

CUR,

Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis

Review,

Arthritis,

*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,

2818-

CUR,

Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways

Review,

AD,

*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,

6702-

DFC,

Diclofenac

Review,

Nor,

*Inflam↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *TXA2↓, *BioAv↑, *Dose↝, *cardioP↓,

1085-

DHA,

EPA,

DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells

in-vitro,

Nor,

HUVECs

50-100uM

low doses (10 µM) of DHA and EPA, but not troglitozone, significantly increased the activity of NF-κB in resting HUVECs.

*COX2/PTGS2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,

6819-

EMD,

Recent advances in the therapeutic potential of emodin for human health

Review,

Nor,

AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,

6827-

EMD,

Mechanism of Emodin in the Treatment of Rheumatoid Arthritis

Review,

Arthritis,

*ALAT↓, *AST↓, *ROS↓, *cardioP↑, *TNF-α↓, *NF-kB↓, *Inflam↓, *AntiArt↑, *PGE2↓, *MMP3↓, *MMP13↓, *COX2/PTGS2↓, *AntiCan↑, *neuroP↑, *hepatoP↑, *antiAll↑,

6378-

Eug,

Effects of Eugenol on the Central Nervous System: Its Possible Application to Treatment of Alzheimer's Disease, Depression, and Parkinson's Disease

Review,

AD,

*other↑, *Aβ↓, *BDNF↑, *MAOA↑, *toxicity↓, *Ca+2↓, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑, *PGE2↓, *COX2/PTGS2↓, *5LO↓,

3714-

FA,

Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review

Review,

AD,

*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,

3778-

FA,

Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review

Review,

AD,

*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,

6995-

Form,

Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia

Review,

Nor,

BV2

*TNF-α↓, *IL6↓, *IL1β↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *neuroP↑, *Inflam↓,

4030-

FulvicA,

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Review,

Nor,

*Inflam↓, TNF-α↓, *COX2/PTGS2↓, *PGE2↓, *ROS↓, *GutMicro↑, *BioEnh↑, *BioEnh↑, *SOD↑, *Catalase↑, *GPx↑,

7028-

GA,

Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

Review,

Nor,

*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,

7090-

GAR,

Garcinol

in-vitro,

Var,

AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,

7238-

GBE,

Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells

in-vitro,

Nor,

RAW264.7

*NO↓, *PGE2↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓,

7212-

GBE,

The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease

Review,

AD,

*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,

7108-

GEN,

Genistein: A Review on its Anti-Inflammatory Properties

Review,

Nor,

*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,

7268-

GGB,

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42

in-vitro,

AD,

*PGE2↓, *Casp3↓, *neuroP↑, *PAF↑,

7140-

GI,

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes

Review,

Var,

*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,

7142-

GI,

Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer

Trial,

Nor,

 2.0 g/day of ginger  ,   healthy volunteers

COX2/PTGS2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,

7151-

GI,

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF7

in-vitro,

Nor,

RAW264.7

MMP9↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓,

7111-

GSL,

In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens

in-vitro,

Nor,

*NO↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓, *Inflam↓,

7489-

H2,

Molecular Hydrogen in the Treatment of Respiratory Diseases

Review,

Asthma,

*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,

2868-

HNK,

Honokiol: A review of its pharmacological potential and therapeutic insights

Review,

Var,

Review,

Sepsis,

*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,

7641-

Ins,

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis

Review,

CRC,

AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,

7884-

isoO,

Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome

in-vitro,

Nor,

RAW264.7

*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,

8105-

KAE,

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Review,

Var,

Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,

8080-

KAE,

Hepatoprotective Effect of Kaempferol—A Review

Review,

Nor,

*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,

8221-

LCA,

Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

in-vitro,

Nor,

*Inflam↓, *AntiBio↑, *PGE2↓, *IL6↓, *TNF-α↓,

8229-

LCA,

Licochalcone A: a review of its pharmacology activities and molecular mechanisms

Review,

Nor,

*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,

8236-

LE,

Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects

Review,

Var,

Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,

Showing Research Papers: 1 to 50 of 79
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 79

Pathway results for Effect on Cancer / Diseased Cells:

Barriers & Transport(tgid=15) ⓘ

MMP↓, 7,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1, CD8+↑, 1, COX2/PTGS2↓, 2, COX2/PTGS2↑, 1, CXCR4↓, 1, FOXP3↑, 1, ICAM-1↓, 2, IL1β↓, 1, IL6↓, 1, IL6↑, 1, IL8↓, 2, Imm↑, 1, Inflam↓, 2, NF-kB↓, 8, NF-kB↑, 1, p‑NF-kB↑, 1, NK cell↑, 1, NLRP3↓, 2, NLRP3↑, 1, p65↓, 1, p‑p65↓, 1, PD-L1↓, 1, PSA↓, 1, TLR4↓, 1, TNF-α↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, ADAM10?, 1, BChE↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, ChemoSen↑, 7, Dose↑, 1, Dose↝, 5, eff↑, 1, eff↝, 1, P-gp/ABCB1↓, 2, P-gp/ABCB1⇅, 1, RadioS↑, 1, selectivity↑, 2, Synergy↑, 5,

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1, EGFR↓, 1, FOXM1↓, 2, IL6↓, 1, IL6↑, 1, LDH↓, 1, PD-L1↓, 1, PSA↓, 1, TF-Ag↓, 1, TG/TAG↓, 1, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1, AntiCan↑, 6, AntiTum↑, 2, cardioP↑, 1, chemoP↑, 5, chemoPv↑, 1, cognitive↑, 1, Pain↓, 1, QoL↑, 1, radioP↑, 1, Risk↓, 2, toxicity↓, 1, toxicity↝, 1, TumVol↓, 2, TumW↓, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1, GutMicro↑, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 248

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 27, ARE↑, 1, Bil↑, 2, Catalase↑, 19, DPPH↓, 1, Fenton↓, 3, GCLC↑, 2, GCLM↑, 2, GPx↓, 1, GPx↑, 13, GSH↑, 16, GSR↓, 1, GSR↑, 4, GSSG↓, 1, GSTs↑, 5, H2O2↓, 1, HO-1↑, 15, Keap1↓, 1, lipid-P↓, 19, MDA↓, 18, MPO↓, 5, NOX↓, 1, NOX4↓, 1, NQO1↑, 3, NRF2↓, 1, NRF2↑, 21, RNS↓, 1, ROS?, 1, ROS↓, 44, SOD↑, 30, TAC↑, 2, TBARS↓, 2, Thiols↑, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1, mitResp↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1, 5-HETE↓, 1, 5LO↓, 8, ALAT↓, 10, AMPK↓, 1, AMPK↑, 3, p‑AMPK↑, 1, ATP↓, 1, ATP↑, 2, cAMP↑, 2, cPLA2↓, 1, DGAT1↓, 1, Eic↓, 1, FASN↓, 1, GlutMet↑, 1, GSK‐3β↓, 4, GSK‐3β↑, 1, H2S↑, 1, LDL↓, 1, lipidLev↓, 1, NAD↓, 1, NADPH↓, 2, NADPH↑, 1, PLA2↓, 1, SIRT1↑, 5,

Cell Death(tgid=5) ⓘ

AIF↓, 1, Apoptosis↓, 6, BAX↓, 6, Bcl-2↓, 1, Bcl-2↑, 1, Bcl-xL↑, 1, Casp3↓, 12, Casp8↓, 1, Casp9↓, 7, Cyt‑c↓, 4, Fas↓, 1, Ferroptosis↓, 1, iNOS↓, 28, iNOS↑, 1, p38↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3, Akt↑, 4, ERK↓, 2, IKKα↓, 1, IKKα↑, 1, IκB?, 1, JAK2↑, 1, JNK↓, 1, p‑JNK↓, 1, MAPK?, 1, MAPK↓, 8, p‑MAPK?, 1, p‑MAPK↓, 1, mTOR↑, 2, mTOR↝, 1, PI3K↓, 3, PI3K↑, 4, STAT↓, 1, STAT3↓, 2, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF4↓, 1, cJun↓, 1, p‑cJun↓, 1, OCT4↓, 1, other↑, 13, other↝, 2, RUNX2↑, 1, SOX9↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, HSP70/HSPA5↑, 2, HSPs↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2, LC3II↓, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, DNArepair↑, 1, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, cFos↓, 1, Choline↑, 1, Diff↑, 1, MSCs↑, 1, TumCP↓, 1, tyrosinase↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 4, AP-1↓, 5, Ca+2↓, 4, COL1↓, 1, COL1↑, 1, COL2A1↑, 1, EMT↓, 1, MMP1↓, 1, MMP13↓, 5, MMP2↓, 4, MMP3↓, 4, MMP3↑, 1, MMP9↓, 6, MMPs↓, 3, MMPs↑, 1, MUC1↑, 1, p‑Rac1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, Snail↑, 1, TGF-β↓, 2, TGF-β↑, 2, TIMP1↓, 1, TIMP1↑, 1, TumCI↓, 1, TumCMig↓, 1, Twist↑, 1, Vim↑, 1, α-SMA↓, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2, angioG↑, 1, angioG↝, 1, E-sel↓, 1, eNOS↓, 1, NO↓, 27, NO↑, 1, TXA2↓, 3, VCAM-1↓, 4, VEGF↓, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 8, CLDN1↑, 1, CLDN3↑, 1, GastroP↑, 1, IBI↑, 1, MMP↑, 6, MUC19↓, 1, MUC2↓, 1, OATPs↓, 1, OCLN↑, 1, TRPA1↑, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↑, 1, COX1↓, 5, COX2/PTGS2↓, 53, COX2/PTGS2∅, 1, CXCc↓, 1, CXCR4↓, 1, FOXP3↑, 1, HMGB1↓, 2, ICAM-1↓, 5, IFN-γ↓, 7, IFN-γ↑, 1, IL1↓, 1, IL10↓, 6, IL10↑, 7, IL12↓, 4, IL17↓, 4, IL18↓, 2, IL1β↓, 33, IL2↓, 5, IL2↑, 1, IL4↓, 5, IL4↑, 2, IL5↓, 3, IL6↓, 39, IL8↓, 8, Imm↓, 1, Imm↑, 1, INF-γ↓, 2, Inflam↓, 49, Inflam↑, 1, IP-10/CXCL-10↓, 1, M2 MC↑, 1, MCP1/CCL2↓, 6, MIP2↓, 1, NF-kB↓, 39, NF-kB↑, 2, NLRP3↓, 8, PAF↑, 1, PGD2↓, 1, PGE2↓, 79, PGE2↑, 1, RANTES↓, 1, Th1 response↓, 1, Th2↑, 2, TLR2↓, 2, TLR4↓, 7, TNF-α↓, 44, TNF-α↑, 1, Treg lymp↝, 1, VitD↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, Ach↑, 2, AChE↓, 4, BDNF↓, 1, BDNF↑, 5, BrainVol↑, 1, ChAT↑, 2, DA↑, 1, GABA↑, 1, MAOA↓, 2, MAOA↑, 1, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 9, BACE/β-secretase↓, 2, tau↓, 1, β-Amyloid↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1, PPARγ↓, 2, PPARγ↑, 5,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7, BioAv↑, 13, BioAv↝, 5, BioEnh↑, 6, CYP2E1↓, 2, CYP3A2↓, 1, Dose↓, 1, Dose↑, 1, Dose⇅, 1, Dose↝, 10, eff↑, 6, eff↝, 1, GSTA1↑, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 4, P-gp/ABCB1↓, 2, P450↝, 1, Synergy↑, 5,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10, ALP↓, 1, AST↓, 10, Bil↑, 2, BloodF↑, 2, BMD↑, 2, BP↓, 2, Calcium↑, 1, creat↓, 1, CRP↓, 1, IL6↓, 39, LDH↓, 4, Mag↑, 1, NOS2↓, 1, SpO2↑, 1, VitD↑, 1,

Functional Outcomes(tgid=23) ⓘ

antiAll?, 1, antiAll↑, 9, AntiArt↑, 1, AntiCan↑, 3, AntiDiabetic↓, 1, AntiDiabetic↑, 6, cardioP↓, 1, cardioP↑, 14, chemoP↑, 2, cognitive↑, 15, cough?, 1, hepatoP↑, 15, memory↑, 7, Mucositis↓, 1, neuroP↑, 32, Obesity↓, 3, OS↑, 1, PDE4↓, 1, radioP↑, 2, RenoP↑, 5, SoreThr?, 1, Stroke↓, 2, toxicity↓, 11, toxicity↑, 1, toxicity↝, 3, toxicity∅, 2, Weight↓, 1, Weight↑, 1, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5, AntiFungal↑, 4, AntiP↑, 1, AntiViral↑, 2, Bacteria↓, 2, GutMicro↑, 8, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 321

Scientific Paper Hit Count for: PGE2, Prostaglandin E2

4 Ginger/6-Shogaol/Gingerol
4 Curcumin
4 Magnetic Fields
4 Piperine
4 Thymoquinone
3 Rosmarinic acid
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Eugenol
2 Capsaicin
2 Baicalein
2 Boswellia (frankincense)
2 Emodin
2 Ferulic acid
2 Ginkgo biloba
2 Kaempferol
2 Licochalcone A
2 Licorice
2 Luteolin
2 Propolis -bee glue
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Betulinic acid
1 Boron
1 Carvacrol
1 Celastrol
1 Chlorogenic acid
1 Lecithin
1 Diclofenac
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Formononetin
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 Honokiol
1 Inositol
1 isoorientin
1 Chrysin
1 Magnolol
1 Moringa oleifera
1 Piperlongumine
1 Resveratrol
1 α-Santalol/Sandalwood oil
1 Sesame seeds and Oil
1 Silymarin (Milk Thistle) silibinin
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin D3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:248  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

PGE2 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

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