TNF-α Cancer Research Results

TNF-α, TNF-α: Click to Expand ⟱
Source: HalifaxProj (block)
Type:
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6468- 1,8-Cin,    Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *antiAll↑,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
9258- Acai, EO,    Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
- in-vivo, CRC, NA
Risk↓, *MPO↓, *TNF-α↓, *IL1β↓, *IL6↓, *PCNA↓, *Bcl-2↓, *cl‑Casp3↓, *COX2/PTGS2?,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1/CCL2↓, *NF-kB↓, IKKα↓,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↓, *PI3K↑, *Akt↑, *mTOR↑,
6403- ANE,    Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease
- in-vivo, Nor, NA
*LDH↓, *IL6↓, *TNF-α↓, *BP↓,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1/CCL2↓, *NO↓, *iNOS↓, *IκB↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5573- B-Gluc,    Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages
- in-vitro, Nor, NA
*Dectin1↑, *Imm↑, *TNF-α↓,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, Var, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, AD, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6495- BCP,    Beta-caryophyllene is a dietary cannabinoid
- Study, Nor, NA
*CB2 / CNR2↑, *other↝, *Inflam↓, *TNF-α↓, *IL1β↓, *ERK↓, *JNK↓,
6506- BCP,    Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
- vitro+vivo, Nor, HMC3
*neuroP↑, *NF-kB↓, *SIRT1↑, *PGC-1α↓, *BDNF↓, *TNF-α↓, *IL6↓, *IL10↑, *Inflam↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *Hcy/homoC↓, *TNF-α↓, *other↝, *memory↑,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,

Showing Research Papers: 1 to 50 of 396
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 396

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 4,   Catalase↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 8,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 5,   Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 5,   NRF2↑, 5,   ROS↓, 11,   ROS↑, 44,   selenoP↑, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 1,   SOD2↓, 1,   Thiols↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 2,   compIV↓, 1,   ETC↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 5,   OXPHOS↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY↓, 1,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 3,   ATP↑, 1,   BHB↑, 1,   CAIX/CA9↓, 1,   CRM↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 7,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 4,   HMGCS2↑, 1,   lactateProd↓, 3,   LDHA↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 2,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 42,   ASC↓, 1,   BAD↓, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 2,   BAX↑, 21,   BAX⇅, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 23,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↑, 1,   BNIP3↝, 1,   Casp↑, 6,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 31,   cl‑Casp3↑, 5,   cl‑Casp3⇅, 1,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 10,   cl‑Casp8↑, 1,   Casp9↑, 19,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 18,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 5,   Fas↑, 5,   FasL↑, 2,   Ferroptosis↑, 1,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 3,   Mcl-1↓, 2,   MDM2↓, 2,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↓, 1,   p38↑, 4,   p‑p38↑, 1,   Perforin↝, 1,   Pyro↑, 1,   survivin↓, 9,   TumCD↓, 1,   TumCD↑, 3,   XIAP↓, 4,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 30,   Akt↑, 1,   p‑Akt↓, 9,   Akt2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 5,   EGFR↑, 2,   ERK↓, 6,   ERK↑, 1,   p‑ERK↓, 2,   HCAR2↑, 2,   HER2/EBBR2↓, 4,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 1,   IKKα↓, 3,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 4,   JNK↑, 4,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 8,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 17,   mTOR↝, 1,   p‑mTOR↓, 1,   P70S6K↓, 2,   p‑PDGFR-BB↓, 1,   PI3K↓, 24,   p‑PI3K↓, 3,   PKCδ↓, 2,   PTEN↓, 2,   PTEN↑, 3,   RAS↓, 2,   RAS↑, 1,   SHP1↑, 1,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 20,   p‑STAT3↓, 3,   STAT4↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 4,   cJun↓, 1,   cMyc↓, 8,   cMyc↑, 1,   DNMT1↓, 3,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 2,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 10,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 1,   miR-124-3p↓, 1,   miR-200b↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 2,   MYCN↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 2,   PAX2↓, 1,   SOX2↓, 2,   SOX9↓, 1,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 2,   ER Stress↑, 11,   GRP78/BiP↑, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 4,   HSPs↓, 1,   NQO2↑, 1,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 3,   CTSB↓, 1,   CTSD↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 8,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 12,   hTERT/TERT↓, 1,   P53↓, 3,   P53↑, 17,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   PCNA↓, 9,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 9,   CDK4↑, 1,   CDK6↓, 1,   CDK6↑, 1,   CHK1↓, 1,   Cyc↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 14,   cycE/CCNE↓, 1,   E2Fs↓, 2,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 1,   P21↑, 9,   pRB↓, 1,   p‑RB1↓, 2,   TumCCA↑, 39,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD133↑, 1,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 8,   Diff↓, 1,   EIF4E↓, 1,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 3,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH3↓, 1,   Shh↓, 1,   STAT1↓, 1,   STAT1↑, 1,   TumCG↓, 12,   TumCP↓, 28,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 6,   EMT↓, 15,   EMT↝, 1,   EpCAM↓, 2,   FAK↓, 1,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 1,   MET↑, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP2↓, 14,   MMP7↓, 1,   MMP9↓, 17,   MMP9↑, 1,   MMPs↓, 11,   N-cadherin↓, 8,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 2,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   pol-TregCell↓, 1,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 15,   TumCMig↓, 18,   TumCMig⇅, 1,   TumMeta↓, 13,   TumMeta↑, 1,   Twist↓, 4,   Tyro3↓, 1,   uPA↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   HIF-1↓, 1,   Hif1a↓, 8,   NO↓, 1,   NO↑, 1,   VEGF↓, 28,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 1,   GLUT1↓, 2,   GLUT2↓, 1,   MMP↓, 10,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   cGAS–STING↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCR3↓, 1,   CXCR4↓, 4,   DR4↑, 2,   FOXP3↑, 1,   HCAR2↑, 2,   HMGB1↓, 1,   ICAM-1↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 8,   IL2↓, 1,   IL2↑, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 9,   Imm↝, 1,   Inflam↓, 6,   Inflam↑, 1,   LPS↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 3,   NLRP3↑, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE2↓, 6,   PSA↓, 3,   TLR4↓, 2,   TNF-α↓, 4,   TNF-α↑, 2,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER(estro)↑, 1,   PPARα↓, 1,   PPARγ↓, 4,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 8,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↑, 43,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   DDS↑, 1,   Dose↑, 1,   Dose↝, 13,   eff↓, 2,   eff↑, 11,   eff⇅, 1,   eff↝, 2,   eff∅, 1,   Half-Life↓, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   RadioS↑, 11,   selectivity↑, 11,   Synergy↑, 35,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   AR↓, 5,   ascitic↓, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 2,   EGFR↓, 5,   EGFR↑, 2,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 1,   IL6↓, 9,   KRAS↓, 2,   LDH↓, 1,   LDH↑, 1,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 2,   PSA↓, 3,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 19,   antiNeop↑, 1,   AntiTum↑, 6,   Appetite↑, 1,   cachexia↓, 2,   cardioP↑, 4,   chemoP↑, 18,   chemoPv↑, 4,   cognitive?, 1,   cognitive↑, 4,   hepatoP↑, 2,   K17↓, 1,   neuroP↑, 3,   NP/CIPN↓, 2,   OS?, 1,   OS↑, 3,   Pain↓, 2,   PFS↑, 1,   QoL↑, 5,   radioP↑, 7,   RenoP↑, 7,   Risk↓, 10,   Sleep↑, 1,   toxicity↓, 3,   TumVol↓, 6,   TumW↓, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 515

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 6,   antiOx↑, 147,   ARE↑, 4,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 94,   DPPH↓, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 3,   GPx↑, 57,   GPx1↑, 2,   GPx4↓, 1,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 104,   GSH/GSSG↑, 1,   GSR↓, 3,   GSR↑, 7,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 16,   H2O2↓, 7,   HDL↑, 7,   HDL∅, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 92,   HO-1↝, 1,   hyperG↝, 1,   Iron↓, 2,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 72,   lipid-P↑, 2,   mt-lipid-P↓, 1,   MDA↓, 102,   MPO↓, 23,   NFE2L2↓, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 5,   NQO1↑, 23,   NQO1↝, 1,   Nrf1↑, 2,   NRF2?, 1,   NRF2↓, 5,   NRF2↑, 132,   PCO↓, 1,   Prx↑, 1,   RNS↓, 6,   ROS?, 1,   ROS↓, 241,   ROS↑, 3,   ROS⇅, 2,   ROS↝, 1,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 2,   SOD↑, 137,   SOD1↑, 5,   SOD2↑, 4,   TAC↑, 14,   TBARS↓, 6,   Thiols↑, 2,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 11,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   FIS1↓, 1,   Insulin↓, 3,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 7,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 6,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   15-LOX/ALOX15↓, 1,   5LO↓, 9,   ACADS/SCAD↑, 1,   ACC↓, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 2,   ALAT↓, 39,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   ATP↓, 1,   ATP↑, 14,   ATP↝, 1,   cAMP↑, 3,   CPT1A↑, 2,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   FFA/NEFA↓, 2,   glucose↓, 8,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 21,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 2,   HMG-CoA↓, 1,   KeyT↝, 1,   LDL↓, 18,   lipidLev↓, 4,   NAD↓, 1,   NAD↑, 2,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 8,   NADPH↑, 4,   PFK↓, 1,   PKM2↓, 1,   PLA2↓, 2,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 21,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 39,   ASC↓, 2,   BAD↓, 1,   BAX↓, 24,   BAX↑, 3,   Bax:Bcl2↓, 5,   Bcl-2↓, 7,   Bcl-2↑, 24,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   Casp12↓, 3,   Casp3↓, 50,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 20,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 8,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 83,   iNOS↑, 2,   MLKL↓, 1,   necrosis↓, 3,   p38↓, 12,   p‑p38↓, 4,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 16,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 5,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 4,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 13,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 2,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 1,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 18,   p‑JNK↓, 8,   MAPK?, 1,   MAPK↓, 28,   MAPK↑, 2,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 7,   mTOR↑, 5,   mTOR↝, 1,   p‑mTOR↓, 4,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 10,   PI3K↑, 11,   PI3K↝, 1,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 2,   PTEN↓, 2,   RIP1↓, 2,   STAT↓, 2,   STAT3↓, 7,   STAT3↑, 4,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF4↓, 3,   cJun↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HDAC↓, 3,   HDAC↑, 1,   HDAC2↓, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 3,   other↑, 14,   other↝, 18,   other∅, 1,   RUNX2↑, 1,   SOX2↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 10,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 11,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 2,   UPR↑, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 5,   CTSZ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   P53↓, 5,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 2,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 3,   Ki-67↑, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   CEBPA↓, 1,   Choline↑, 2,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   Ki-67↓, 3,   Ki-67↑, 1,   MSCs↑, 1,   Nestin↑, 1,   neuroG↑, 6,   NOTCH1↑, 1,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 7,   AP-1↓, 8,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 15,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 7,   COL1↓, 2,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP-10↓, 1,   MMP-10↝, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP2↓, 7,   MMP2↑, 2,   MMP3↓, 5,   MMP9↓, 15,   MMPs↓, 4,   MUC1↑, 2,   Na+↑, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 2,   Sema3A/PlexinA1↑, 1,   serineP↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 8,   TGF-β↑, 5,   TGF-β1↓, 2,   TGF-β1↑, 3,   TIMP1↓, 3,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 2,   uPA↑, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   angioG↝, 1,   E-sel↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 1,   LOX1↓, 1,   NO↓, 55,   NO↑, 5,   VCAM-1↓, 10,   VEGF↓, 4,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 33,   BBB↝, 5,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 2,   CLDN4↑, 1,   EPR↑, 1,   GastroP↑, 4,   GLUT2↑, 2,   GLUT3↑, 2,   GLUT4↑, 3,   IBI↑, 6,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 17,   MUC2↑, 1,   MUC5AC↓, 1,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 6,   OCLN↝, 1,   TJ↑, 5,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 8,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 4,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 6,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 110,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCL15↓, 1,   CXCR4↓, 1,   DCells↑, 1,   Dectin1↑, 1,   Eos↓, 1,   FOXP3↑, 2,   HMGB1↓, 4,   ICAM-1↓, 11,   IFN-γ↓, 20,   IFN-γ↑, 3,   IL1?, 1,   IL1↓, 17,   IL10↓, 21,   IL10↑, 35,   IL12↓, 8,   IL13↓, 2,   IL17↓, 12,   IL18↓, 5,   IL1α↓, 1,   IL1β↓, 195,   IL1β↑, 1,   IL2↓, 12,   IL2↑, 2,   IL22↓, 3,   IL23↓, 2,   IL33↓, 2,   IL4↓, 13,   IL4↑, 11,   IL5↓, 5,   IL5↑, 1,   IL6?, 2,   IL6↓, 222,   IL6↑, 5,   IL8↓, 28,   IL8↑, 1,   IL9↓, 1,   Imm↓, 1,   Imm↑, 9,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 260,   Inflam↑, 3,   IP-10/CXCL-10↓, 3,   IRF3↓, 3,   LPS↓, 3,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 20,   MCP1/CCL2↑, 1,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 3,   MIP2↓, 3,   MyD88↓, 5,   NeuroI↓, 7,   Neut↓, 1,   NF-kB↓, 174,   NF-kB↑, 2,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 29,   p65↓, 5,   p‑p65↓, 2,   PGE1↓, 1,   PGE2↓, 43,   PGE2↑, 2,   PSA↓, 1,   RAGE↓, 2,   RANTES↓, 3,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 6,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 401,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 6,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 10,   Ach↑, 11,   AChE↓, 42,   ADAM10↑, 1,   BChE↓, 10,   BDNF↓, 2,   BDNF↑, 46,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 6,   ChE↓, 1,   DA↑, 1,   GABA↓, 2,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 8,   MAOA↝, 1,   MAOB↓, 4,   NGF↑, 7,   PSD95?, 1,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 3,   SYN1↑, 1,   SYP↑, 1,   SYT1↑, 1,   TPH1↓, 1,   TrkB↑, 7,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APOE4↓, 1,   APP↓, 9,   cl‑APP↑, 1,   Aβ↓, 68,   Aβ42↓, 4,   BACE/β-secretase↓, 23,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 16,   p‑tau↓, 21,   β-Amyloid↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   AhR↑, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   DHT↓, 1,   DHT↑, 1,   END↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 6,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 17,   p‑PPARγ↓, 1,   SHBG↓, 1,   testos↓, 1,   testos↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 55,   BioAv⇅, 1,   BioAv↝, 28,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 6,   Dose↓, 1,   Dose↑, 7,   Dose⇅, 2,   Dose↝, 69,   eff↓, 3,   eff↑, 37,   eff↝, 2,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 5,   Half-Life↝, 16,   MRP↓, 1,   P-gp/ABCB1↓, 3,   P450↓, 1,   P450↑, 2,   P450↝, 1,   selectivity↑, 2,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 39,   ALB↑, 2,   ALB↝, 1,   ALP↓, 7,   AST↓, 39,   BG↓, 3,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 3,   BP↓, 14,   BUN?, 1,   BUN↓, 6,   Calcium↑, 1,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 1,   creat↓, 16,   CRP↓, 16,   EGFR↓, 2,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 1,   hs-CRP↓, 4,   IL6?, 2,   IL6↓, 222,   IL6↑, 5,   KeyT↝, 1,   LDH↓, 10,   LDH↑, 1,   Mag↑, 1,   NOS2↓, 3,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   TMAO↓, 1,   Urea↓, 3,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 2,   Analgesic↑, 3,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 26,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 2,   AntiDiabetic↓, 1,   AntiDiabetic↑, 22,   antiPs↑, 2,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 69,   chemoP↑, 14,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 91,   cognitive↝, 1,   diuretic↑, 1,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 70,   Learn↑, 12,   memory↑, 71,   Mood↑, 6,   motorD↓, 2,   motorD↑, 16,   Mucositis↓, 1,   neuroP↑, 160,   NP/CIPN↓, 1,   Obesity↓, 13,   OS↑, 7,   Pain↓, 11,   QoL↑, 2,   radioP↑, 10,   RenoP↓, 1,   RenoP↑, 33,   Risk↓, 8,   Sleep↑, 4,   Strength↑, 5,   Stress↓, 2,   Stroke↓, 18,   toxicity↓, 26,   toxicity↑, 1,   toxicity↝, 8,   toxicity∅, 6,   Weight↓, 3,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↑, 5,   AntiP↑, 1,   AntiViral↑, 11,   Bacteria↓, 15,   Dectin1↑, 1,   Diar↓, 2,   GutMicro↑, 37,   Inf↓, 1,   Sepsis↓, 10,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 1,   Ingr↝, 12,  
Total Targets: 737

Scientific Paper Hit Count for: TNF-α, TNF-α
19 Hydrogen Gas
14 Thymoquinone
13 Curcumin
12 Lycopene
12 Silymarin (Milk Thistle) silibinin
11 Magnetic Fields
10 Quercetin
9 isoorientin
7 Boron
7 EGCG (Epigallocatechin Gallate)
7 Luteolin
7 Shikonin
6 Folic Acid, Vit B9
6 Eugenol
6 Urolithin
5 Alpha-Lipoic-Acid
5 Baicalein
5 Cisplatin
5 Beta-Caryophyllene
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Selenium NanoParticles
5 Emodin
5 Honokiol
5 Matrine
5 Propolis -bee glue
5 Rosmarinic acid
4 Berberine
4 Selenium
4 Chlorogenic acid
4 Ferulic acid
4 Kaempferol
4 Morin
4 Sulforaphane (mainly Broccoli)
3 Silver-NanoParticles
3 Artemisinin
3 Ashwagandha(Withaferin A)
3 Vitamin B12
3 Vitamin B3,Niacin
3 Capsaicin
3 Carvacrol
3 Thymol-Thymus vulgaris
3 Chrysin
3 Cichoric acid / Chicoric acid
3 Echinacea
3 Coenzyme Q10
3 Resveratrol
3 Crocetin
3 Dandelion Root
3 Fisetin
3 Gallic acid
3 Ginkgo biloba
3 Hyperoside
3 Isoliquiritigenin
3 Isovitexin
3 L-Theanine
3 Magnesium
3 Pterostilbene
3 Rutin
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Astaxanthin
2 beta-glucans
2 Baicalin
2 Radiotherapy/Radiation
2 Benzyl isothiocyanate
2 borneol
2 buckwheat sprouts
2 Butyrate
2 Cinnamon
2 diet Short Term Fasting
2 D-limonene
2 Formononetin
2 Flaxseed/Linseed
2 Chemotherapy
2 Licochalcone A
2 Lemon Balm/Melissa officinalis
2 doxorubicin
2 Moringa oleifera
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Patchouli Oil (Pogostemon cablin)
2 Piperine
2 Sesame seeds and Oil
2 Selenite (Sodium)
2 Vitamin K2
1 Annona atemoya Seed Extract
1 Açaí, Euterpe oleracea
1 Anthocyanins
1 Fennel Oil/Foeniculum vulgare
1 Apigenin (mainly Parsley)
1 Aloe anthraquinones
1 Biochanin A
1 xanthohumol
1 Betulinic acid
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 brusatol
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Cat’s Claw
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Chyawanprash
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 Diindolylmethane
1 Indole-3-carbinol
1 eicosapentaenoic acid
1 methotrexate
1 Ascorbyl Palmitate
1 Fucoidan
1 Gamma-aminobutyric acid
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Orlistat
1 HydroxyTyrosol
1 Isorhamnetin
1 isoquercitrin
1 Juglone
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Linalool
1 Lutein
1 Magnolol
1 Mung Bean Sprouts
1 Magnetic Field Rotating
1 Zinc
1 Moringin
1 Melatonin
1 Methylene blue
1 5-fluorouracil
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 Piperlongumine
1 Phosphatidylserine
1 Spirulina(Arthrospira/Limnospira)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:309  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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