cJun Cancer Research Results

cJun, cellular Transcription factor Jun: Click to Expand ⟱
Source:
Type: Oncogene
Transcription factor Jun is a protein that in humans is encoded by the JUN gene.
Increased c-jun gene and c-Jun protein expression, and stimulation of c-Jun phosphorylation has been noted under a variety of conditions. Most important member of the AP-1 transcription factor family.
Scientific Papers found: Click to Expand⟱
2669- AL,  Rad,    Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway
- in-vitro, Nor, HUVECs
*ICAM-1↓, *AP-1↓, *p‑cJun↓, *radioP↑, JNK↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
5875- CA,    Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway
- in-vivo, IBD, NA
*antiOx↑, *Weight↑, *p65↓, *cJun↓, *NLRP3↓, *Casp1↓, *NRF2↑, *GSH↑, *SOD↑, *MDA↓, *iNOS↓, other↝,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *PTP1B↓, *cognitive↑, *BDNF↑, *TrkB↝, *cJun↓, *p‑tau↓, *AChE↓, *Ach↑, *Aβ↓, *antiOx↑, *NRF2↑, *AntiViral↑, *Obesity↓, *PI3K↑, *Akt↑, *mTOR↑, *memory↑, *BBB↑,
1680- PBG,    Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative
- in-vitro, Nor, HS68
*ROS↓, *NRF2↑, *HO-1↑, *cJun↓, *MMP1↓, *MMP2↓, *p‑cJun↓, *cFos↓, *BAX↓, *Casp3↓, *DNAdam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *PGE2↓, *NO↓,
3649- SIL,    Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
- in-vitro, Nor, NA
*Inflam↓, *NF-kB↓, *cJun↓, *Casp↓, *ROS↓, *lipid-P↓,
2211- SK,    Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways
- in-vivo, ostP, NA
*BMD↑, *p‑NF-kB↓, *p‑p50↓, *p‑p65↓, *p‑ERK↓, *p‑cJun↓, *p‑p38↓,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, Nor, NA
*COX2/PTGS2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Fas↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JNK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↑, 1,   Catalase↑, 1,   GCLC↑, 1,   GPx↑, 1,   GSH↑, 1,   GSH/GSSG↑, 1,   GSTs↑, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 4,   SOD↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 3,   p‑p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑ERK↓, 1,   mTOR↑, 1,   PI3K↑, 1,   PTP1B↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 5,   p‑cJun↓, 5,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   MMP1↓, 1,   MMP2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 3,   ICAM-1↓, 1,   IL10↑, 1,   IL6↓, 2,   Inflam↓, 3,   NF-kB↓, 3,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 1,   p‑p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 1,   BDNF↑, 1,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   GSTA1↑, 2,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 2,   Obesity↓, 1,   radioP↑, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 85

Scientific Paper Hit Count for: cJun, cellular Transcription factor Jun
2 Licochalcone A
1 Allicin (mainly Garlic)
1 Radiotherapy/Radiation
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Carnosic acid
1 Propolis -bee glue
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:34  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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