β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱
Source: HalifaxProj (inactivate)
Type:
β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.
Scientific Papers found: Click to Expand⟱
1097- AG,    Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin
- in-vitro, Nor, HMrSV5 - in-vivo, NA, NA
*EMT↓, *E-cadherin↑, *α-SMA↓, *Vim↓, *β-catenin/ZEB1↓, *Smad7↑,
1012- EGCG,    Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
- in-vitro, Nor, HEK293
*H2O2↑, *β-catenin/ZEB1↓, *TCF-4↓,
2506- H2,    Molecular hydrogen suppresses activated Wnt/β-catenin signaling
- in-vivo, Arthritis, NA
*Wnt↓, *β-catenin/ZEB1↓, *Dose↝,
7840- ISQ,    Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition
- in-vivo, Diabetic, NA
*Pain↓, *Wnt↓, *β-catenin/ZEB1↓, *neuroP↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

TCF-4↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   Smad7↑, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   Pain↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1
1 Astragalus
1 EGCG (Epigallocatechin Gallate)
1 Hydrogen Gas
1 isoquercitrin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:342  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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